Referenced in: none

Automatically associated channels: Kir2.3

Title: Sodium-potassium pump in low-renin hypertension.

Authors: F J Haddy

Journal, date & volume: Ann. Intern. Med., 1983 May , 98, 781-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6303176

Abstract
Recent studies suggest that sodium-dependent low-renin hypertension in animals results at least in part from sodium-potassium pump inhibition in blood vessels and heart by a humoral agent released from or influenced by the anteroventral third ventricular area of the brain. For example, a high salt intake in a rat with reduced renal mass results in the appearance of a heat-stable sodium pump inhibitor in the plasma, decreased cardiac Na+, K+-ATPase activity, decreased arterial sodium-potassium pump activity, and hypertension. These changes are reversed by reducing the salt intake or by producing a lesion in the anteroventral third ventricular area of the brain. The course of the development of pump inhibition is similar to the course of the development of hypertension. Sodium-potassium pump inhibition by a humoral agent may also occur in humans with low-renin hypertension. A high potassium intake may stimulate pump activity.