Referenced in: none

Automatically associated channels: Kir2.3 , Slo1

Title: Feeding suppression induced by intra-ventricle III infusion of 1,5-anhydroglucitol.

Authors: K Tsutsui, T Sakata, Y Oomura, K Arase, M Fukushima, Y Hinohara

Journal, date & volume: Physiol. Behav., 1983 Oct , 31, 493-502

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6318243

Abstract
1,5-Anhydroglucitol (1-DG) has been known as an antimetabolic glucose analogue. Using gas chromatography, 1-DG was found to be physiologically present in rat serum. In order to investigate its direct and long-term effects on feeding, 1-DG was infused during the light period into the rat third ventricle in doses of 3.0, 6.0 and 12.0 mumol/rat. Its effects were then compared to those of similarly applied 2-deoxy-D-glucose (2-DG). Following initial hyperphagia, both of these glucose-analogues produced suppressive effects on feeding during the subsequent day throughout the light and dark periods. On the third day after 2-DG injection reduction of feeding did not recover completely to the pretreatment baseline levels, but it did recover after 1-DG. Both 1-DG and 2-DG caused linear dose-related hypophagia, with the slope for 1-DG being about half of that for 2-DG. It is suggested that the delayed hypophagia which followed the initial hyperphagia produced by deoxyglucose was a result of sustained inactivation of the Na-pump due to intracellular ATP deficiency caused by accumulation of deoxy-glucose-6-phosphate.