Referenced in: none

Automatically associated channels: Kir2.3

Title: Characterization of calcium and sodium currents in porcine pars intermedia cells.

Authors: O Taleb, J Trouslard, B A Demeneix, P Feltz

Journal, date & volume: Neurosci. Lett., 1986 May 6 , 66, 55-60

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2423930

Abstract
The whole-cell configuration of the patch-clamp technique was applied to porcine pars intermedia cells. A tetrodotoxin-sensitive sodium current was recorded. Three types of calcium current were observed. Depolarizations from a holding potential of 100 mV elicited a transient current (ICaT), whereas depolarizations from a holding potential of -40 mV evoked a sustained current (ICaS). A third current (ICaN; N for neither) was activated by strong depolarization to +10 or +20 mV from holding potentials of - 100 mV. Increasing internal Ca2+ significantly reduced the amplitude of ICaS.