Referenced in: none

Automatically associated channels: Kir2.3

Title: Ca-channel currents in isolated frog ventricular cells are increased by thrombin.

Authors: R Albitz, F Markwardt, T Franke, B Nilius

Journal, date & volume: Biomed. Biochim. Acta, 1989 , 48, S350-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2547360

Abstract
Effects of the proteolytic enzyme thrombin in the modulation of cardiac Ca-channel currents were examined in single ventricular cells from frog myocardium, using the whole-cell voltage clamp technique (1). Application of 3.8 . 10(-9) M thrombin to the bath increased the peak of the Ca-channel current by 84 +/- 35% (8 cells). Hirudin (31.10(-9)M), a specific thrombin inhibitor, blocked the thrombin-induced increase of this current. The increase in the current can be made responsible for the measured positive inotropic effects on frog heart of thrombin.