Referenced in: none

Automatically associated channels: Kir2.3

Title: Alterations in erythrocyte Na+,K+-cotransport in normal and hypertensive human pregnancy.

Authors: E D Gallery, R P Esber, M A Brown, M R Hawkins, M Ross

Journal, date & volume: J. Hypertens., 1988 Feb , 6, 153-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2450910

Abstract
Many physiological variables known or thought to affect erythrocyte Na+,K+-cotransport are altered in pregnancy. The interrelationships of Na+,K+-cotransport and pregnancy were therefore examined. Values were elevated by more than 30% in both second and third trimesters with a return towards non-pregnant levels in the postpartum period. Although pregnancy was also associated with elevated plasma cholesterol, renin activity and aldosterone, there was no significant relationship within the pregnant group between Na+,K+-cotransport and any of these factors. No change could be demonstrated in Na+,K+-cotransport values after 7 days of either high (greater than 250 mmol/day) or low (less than 50 mmol/day) sodium intake and values for those who developed pregnancy-associated hypertension (PAH, pre-eclampsia) were not significantly different from those in continuously normotensive women in either the second or the third trimesters of pregnancy.