Referenced in: none

Automatically associated channels: Kv10.1

Title: Reversine inhibits spontaneous synaptic transmission in cultured rat hippocampal neurons.

Authors: Ruxin Li, Shaoqing Zhu, Xiangping He, Zuoping Xie

Journal, date & volume: Cell Biol. Int., 2007 Jun , 31, 540-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17258475

Abstract
The dedifferentiation agent "reversine" [2-(4-morpholinoanilino)-N6-cyclohexyladenine 2], which can induce myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, was discovered by Shuibing Chen et al. in 2003. But its effects on neurons were unknown. Using patch-clamp technique, we found that reversine inhibits spontaneous synaptic transmission in cultured rat hippocampal neurons without influencing the dynamics function of potassium, sodium and calcium channels. This result suggests that reversine may also act as a dedifferentiation agent in neurons, and inhibiting the synaptic transmission maybe the early step of neuronal dedifferentiation.