Referenced in: none

Automatically associated channels: Kv2.1

Title: Synthesis of mu-conotoxin GIIIA: a chemical probe for sodium channels.

Authors: Y Hatanaka, E Yoshida, H Nakayama, Y Kanaoka

Journal, date & volume: Chem. Pharm. Bull., 1990 Jan , 38, 236-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2159854

Abstract
mu-Conotoxin GIIIA, a 22 amino acid peptide paralytic toxin which inhibits the muscle voltage-activated sodium channels, was synthesized by a solid phase method. No purification of intermediates was necessary for the synthesis, and a simple air oxidation of the deprotected crude peptide gave the desired toxin. By all criteria applied, the synthetic material was indistinguishable from the authentic natural toxin.