Referenced in: none

Automatically associated channels: Kv10.1

Title: [Change in the passive influx of Ca2+ into sarcoplasmic reticulum vesicles as a result of chemical modification of surface amino groups]

Authors: G P Diadiusha, V A Tugaĭ, V P Zimina, A N Zakharchenko

Journal, date & volume: Biokhimiia, 1990 Dec , 55, 2247-54

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1965785

Abstract
Treatment of sarcoplasmic reticulum (SR) vesicles with trinitrobenzene (TNBS) and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) stimulates the initial rate of passive influx of Ca2+ into SR vesicles, but does not affect either the binding or the maximal passive loading of SR vesicles with Ca2+. The changes in the kinetics of KCl-stimulated passive influx of Ca2+ depend on the reagent used. It is supposed that stimulation of passive influx of Ca2+ into SR vesicles and the changes in the reaction kinetics may be caused by modification of the Ca2+ channel gating behaviour as a result of binding of surface amino groups.