Referenced in: none

Automatically associated channels: Kv10.1

Title: Calcium release from frog sarcoplasmic reticulum by an imidazolyl reagent.

Authors: T Aoki, T Oba

Journal, date & volume: Experientia, 1989 Oct 15 , 45, 987-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2478387

Abstract
Calcium is released from the isolated heavy sarcoplasmic reticulum (SR) of frog skeletal muscle upon application of 0.1-1 mM diethylpyrocarbonate (DEP, an imidazolyl reagent). The Ca-ATPase activity of SR was suppressed by 20% in the presence of 1 mM DEP. More than 1 mM of free magnesium ion or 5 microM ruthenium red eliminated the effect of DEP on calcium release but not on Ca-ATPase activity. A plausible site of DEP action is on the calcium channel.