Referenced in: none

Automatically associated channels: Kv1.4

Title: Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library.

Authors: J C Tseng-Crank, G N Tseng, A Schwartz, M A Tanouye

Journal, date & volume: FEBS Lett., 1990 Jul 30 , 268, 63-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2384173

Abstract
A full-length K+ channel cDNA (RHK1) was isolated from a rat cardiac library using the polymerase chain reaction (PCR) method and degenerate oligonucleotide primers derived from K+ channel sequences conserved between Drosophila Shaker H4 and mouse brain MBK1. Although RHK1 was isolated from heart, its expression was found in both heart and brain. The RHK1-encoded protein, when expressed in Xenopus oocytes, gated a 4-aminopyridine (4-AP)-sensitive transient outward current. This current is similar to the transient outward current measured in rat ventricular myocytes with respect to voltage-dependence of activation and inactivation, time course of activation and inactivation, and pharmacology.