Referenced in: none

Automatically associated channels: Kv10.1

Title: [ATP level in synaptosomes--a determining factor of the functional activity of ion channels induced by alpha-latrotoxin]

Authors: T A Pivneva, N G Gimmel'reĭkh, E V Nikolishina

Journal, date & volume: Ukr. Biokhim. Zh., 1988 Jan-Feb , 60, 65-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2452502

Abstract
The paper deals with characteristics of relationship between synaptosomal calcium permeability induced by alpha-latrotoxin and cytosolic concentration of ATP. It is shown that reagents decreasing the ATP level in the synaptosomes (monoiodoacetate, papaverine) inactivate the toxin-induced ionic fluxes and, on the contrary, reagents increasing the ATP level in synaptosomes enhance the toxin-induced calcium influx. The treatment of synaptosomes with inhibitors of phosphodiesterase of cAMP and cAMP-dependent protein kinase has no effect on the alpha-latrotoxin-induced calcium influx.