Referenced in: none

Automatically associated channels: Kir2.3 , Slo1

Title: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.

Authors: B P Rosen

Journal, date & volume: Res. Microbiol., 1990 Mar-Apr , 141, 336-41

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1704144

Abstract
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.