Referenced in: none

Automatically associated channels: Kv2.1

Title: Expression and chromosomal localization of a lymphocyte K+ channel gene.

Authors: S Grissmer, B Dethlefs, J J Wasmuth, A L Goldin, G A Gutman, M D Cahalan, K G Chandy

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 1990 Dec , 87, 9411-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2251283

Abstract
We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively.