Referenced in: none

Automatically associated channels: Kv10.1

Title: Pharmacology of the Ca2(+)-dependent K+ channel in corn protoplasts.

Authors: K A Ketchum, R J Poole

Journal, date & volume: FEBS Lett., 1990 Nov 12 , 274, 115-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1701395

Abstract
We investigated the sensitivity of the Ca2(+)-dependent K+ current, IK(Ca), present in corn protoplasts, to different K+ channel blockers. IK(Ca) was inhibited by external Cs+ (10 mM), Ba2+ (10 mM), and quinine (0.5 mM): reagents which block many types of outward-rectifying K+ channels. In contrast 4-aminopyridine (5 mM), an inhibitor of delayed rectifier or inactivating K+ currents, had no effect. Neither of the peptide toxins, apamin or charybdotoxin, specific for Ca2(+)-dependent K+ channels in animal cells, inhibited currents when used in the nanomolar concentration range. However, higher levels of charybdotoxin (10 microM) caused marked reduction of IK(Ca).