Referenced in: none

Automatically associated channels: Kv10.1

Title: [Effect of protein-modifying factors on sodium and potassium leakage currents of the secretory cell membranes]

Authors: M Iu Klevets

Journal, date & volume: , 1989 Mar-Apr , 35, 3-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2542099

Abstract
Potassium and sodium leakage currents decrease when pH of the surroundings is lowering. Dicyclohexylcarbodiimide, a specific reagent of the COOH-groups does not change leakage currents. Trypsin, chymotrypsin, papain and pronase increase the sodium leakage current, not altering the potassium one. Blocking agents of the SH-groups: Hg2+ and Cd2+ decrease potassium leakage current, without changing the sodium one. Results of the proteolysis testify to that the diffusion of sodium into the cells in response is accomplished through the protein components of the membrane. The action of the blocking agents of SH-groups points out that the diffusion of potassium from the cells is realized also via the protein components of the membrane.