Title: Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels.

Authors: D Daly, A Al-Sabi, G K Kinsella, K Nolan, J O Dolly

Journal, date & volume: Chem. Commun. (Camb.), 2015 Jan 21 , 51, 1066-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25435252

Abstract
Selective inhibitors of voltage-activated K(+) channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.