Title: Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability.

Authors: Leonard K Kaczmarek

Journal, date & volume: Neuron, 2019Aug21, 103, 551-553

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/31437449

Abstract
Mutations in voltage-dependent sodium channels cause severe autism/intellectual disability. In this issue of Neuron, Spratt et al. (2019) show that lowering expression of Nav1.2 channels attenuates backpropagation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent synaptic plasticity.