Referenced in: none

Automatically associated channels: Kv3.1

Title: Down-regulation of Na channel expression by A23187 in N1E-115 neuroblastoma cells.

Authors: J K Hirsh, F N Quandt

Journal, date & volume: Brain Res., 1996 Jan 15 , 706, 343-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8822380

Abstract
Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal Ca may therefore control excitability by independent regulation of Na and K channel mRNA abundance in neurons.