Referenced in: none

Automatically associated channels: Kv11.1 , Kv7.1

Title: Molecular physiology of cardiac delayed rectifier K+ channels.

Authors: M C Sanguinetti, A Zou

Journal, date & volume: , 1997 , Suppl 12, 170-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9476573

Abstract
Delayed rectifier K+ current in cardiac myocytes is the sum of two distinct currents, IKr and IKs. The molecular basis of these channels has recently been defined. HERG subunits coassemble to form IKr channels. KvLQT1 and minK subunits coassemble to form IKs channels. Mutations in HERG or KVLQT1 genes predispose affected individuals to ventricular arrhythmias and sudden death.