Referenced in: none

Automatically associated channels: ClC4 , ClC5

Title: Role of ClC-5 in the pathogenesis of hypercalciuria: recent insights from transgenic mouse models.

Authors: A S Yu

Journal, date & volume: Curr. Opin. Nephrol. Hypertens., 2001 May , 10, 415-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11342807

Abstract
Dent's disease is an inherited disorder characterized by hypercalciuria, low molecular weight proteinuria, and Fanconi syndrome, which is caused by inactivating mutations in ClC-5, a chloride channel expressed in endosomes of the proximal renal tubule. The role of ClC-5 in the pathogenesis of the hypercalciuria and other myriad manifestations of this disease, however, is largely unknown. New insights from three new transgenic mouse models of Dent's disease, reported in the past year, are discussed.