Referenced in: none

Automatically associated channels: SK3

Title: Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

Authors: Thomas Blank, Ingrid Nijholt, Min-Jeong Kye, Jelena Radulovic, Joachim Spiess

Journal, date & volume: Nat. Neurosci., 2003 Sep , 6, 911-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12883553

Abstract
Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.