Referenced in: none

Automatically associated channels: ClC3 , ClC4

Title: [Expression of chloride channel in nasal mucosa with allergic rhinitis]

Authors: Hua-Bin Li, De-min Han, Bing Zhou, Xiang-dong Wang, Zhong-yan Liu, Ling Yang

Journal, date & volume: Zhonghua Er Bi Yan Hou Ke Za Zhi, 2003 Apr , 38, 86-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12889100

Abstract
To evaluate the role of chloride channel ClC-3 in perennial allergic rhinitis.The nasal mucosa from 19 patients with perennial allergic rhinitis were studied by immunohistochemistric staining and reverse transcriptase polymerase chain reaction (RT-PCR) for the expression of ClC-3.ClC-3 was positively stained in 17 cases of 19 patients, with a rate of 89.6%. It mainly distributed in cytoplasm of epithelium and submucosal gland. All tissues displayed expected DNA length after PCR. The relative density of ClC-3 in mucosa with allergic rhinitis was 0.685 +/- 0.114 and 0.140 +/- 0.075 in normal.ClC-3 played an important role in the over-secretion of liquor in allergic rhinitis.