Referenced in: none

Automatically associated channels: Kv1.4 , Kv1.5 , Kv3.1 , Kv7.1

Title: Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice.

Authors: Gideon Koren

Journal, date & volume: Ann. Med., 2004 , 36 Suppl 1, 22-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15176420

Abstract
Mutations in cardiac voltage-gated K+ channels cause long-QT syndrome (LQTS) and sudden death. We have created a mouse with a long-QT phenotype by overexpression of truncated K+ channels in the heart and have investigated the phenotype of these mice. These mice have long-QT phenotype, and spontaneous and inducible arrhythmias. Optical mapping of Kv1DN mice revealed spatial and temporal dispersion of repolarization that underlies the arrhythmias. Here I review our attempts to abolish arrhythmias in this model by crossbreeding with Kv4DN and Kv2DN mice or direct injection of adenoviral or adeno-associated viral vectors expressing wild-type Kv1.5 (AV-Kv1.5) into the myocardium. Our published work suggests that the viral vectors rescue the phenotype at the cellular level, while crossbreeding with Kv4DN mice attenuates the spontaneous and inducible arrhythmias.