Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1 , TRPV2 , TRPV4

Title: Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells.

Authors: Attila Gábor Szöllősi, Attila Oláh, István Balázs Tóth, Ferenc Papp, Gabriella Czifra, Gyorgy Panyi, Tamás Bíró

Journal, date & volume: FEBS Lett., 2013 May 2 , 587, 1440-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23542034

Abstract
Our goal was to investigate the effect of heat shock on human monocyte-derived dendritic cells (DCs) and to dissect the role of thermosensitive transient receptor potential (TRP) channels in the process. We provide evidence that a short heat shock challenge (43 °C) decreased the endocytotic activity of the DCs and that this effect could be alleviated by the RNAi-mediated knockdown of TRPV2 but, importantly, not by the pharmacological (antagonists) or molecular (RNAi) suppression of TRPV1 and TRPV4 activities/levels. Likewise, the heat shock-induced robust membrane currents were selectively and markedly inhibited by TRPV2 "silencing" whereas modulation of TRPV1 and TRPV4 activities, again, had no effect. These intriguing data introduce TRPV2-coupled signaling as a key player in mediating the cellular actions of heat shock on DCs.