Referenced in: none

Automatically associated channels: HCN1 , Kv1.4 , Kv3.1 , Kv4.2

Title: Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.

Authors: Béatrice Marcelin, Joaquin N Lugo, Amy L Brewster, Zhiqiang Liu, Alan S Lewis, Shawn McClelland, Dane M Chetkovich, Tallie Z Baram, Anne E Anderson, Albert Becker, Monique Esclapez, Christophe Bernard

Journal, date & volume: J. Biol. Chem., 2012 May 18 , 287, 17656-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22511771

Abstract
The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place. We report enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) up-regulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.