Referenced in: none

Automatically associated channels: Kir2.1

Title: [Expression of selected genes involved in transport of ions in papillary thyroid carcinoma.]

Authors: Gałęza-Kulik, Zebracka, Szpak-Ulczok, Czarniecka, Kukulska, Gubała, Stojcev, Wiench

Journal, date & volume: , 2006 , 57, 26-31

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17091453

Abstract
The studies of papillary thyroid cancer (PTC) gene expression profile have shown changes in expression of genes involved in transport of several ions. The aim of our study was a real-time PCR evaluation of three of them: KCNJ2, SLC4A4 and SLC34A2.The analysis was carried out in PTC tumors and normal thyroid samples gained from 38 patients. Real-time quantitative PCR (Q-PCR) was performed (Taqman) with beta-glucuronidase (GUS) as the reference gene.We observed 20 x increase of SLC34A2 expression in PTC. This gene encodes Na+/PO(4) (3-) cotransporter. Considerable increase of gene expression has been shown also for KCNJ2, encoding a potassium ion channel. SLC4A4, which encodes the Na+/HCO(3) (2-) cotransporter, exhibited a 7-fold decrease in PTC.The performed study revealed that SLC34A2 gene exhibited the most distinct change in expression and may become a molecular marker of papillary thyroid cancer.