Referenced in: none

Automatically associated channels: Kv4.1

Title: A hierarchy of cell intrinsic and target-derived homeostatic signaling.

Authors: Sharon Bergquist, Dion K Dickman, Graeme W Davis

Journal, date & volume: Neuron, 2010 Apr 29 , 66, 220-34

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20434999

Abstract
Homeostatic control of neural function can be mediated by the regulation of ion channel expression, neurotransmitter receptor abundance, or modulation of presynaptic release. These processes can be implemented through cell autonomous or intercellular signaling. It remains unknown whether different forms of homeostatic regulation can be coordinated to achieve constant neural function. One way to approach this question is to confront a simple neural system with conflicting perturbations and determine whether the outcome reflects a coordinated, homeostatic response. Here, we demonstrate that two A-type potassium channel genes, shal and shaker, are reciprocally, transcriptionally coupled to maintain A-type channel expression. We then demonstrate that this homeostatic control of A-type channel expression prevents target-dependent, homeostatic modulation of synaptic transmission. Thus, we uncover a homeostatic mechanism that reciprocally regulates A-type potassium channels, and we define a hierarchical relationship between cell-intrinsic control of ion channel expression and target-derived homeostatic control of synaptic transmission.