Referenced in: none

Automatically associated channels: Cav2.1

Title: The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings.

Authors: Jaap J Plomp, Arn M J M Van Den Maagdenberg, Simon Kaja

Journal, date & volume: Cerebellum, 2009 Sep , 8, 222-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19484318

Abstract
Homozygous rolling Nagoya natural mutant mice display a severe ataxic gait and frequently roll over to their side or back. The causative mutation resides in the Cacna1a gene, encoding the pore-forming alpha(1) subunit of Ca(v)2.1 type voltage-gated Ca(2+) channels. These channels are crucially involved in neuronal Ca(2+) signaling and in neurotransmitter release at many central synapses and, in the periphery, at the neuromuscular junction. We here review the behavioral, histological, biochemical, and neurophysiological studies on this mouse mutant and discuss its usefulness as a model of human neurological diseases associated with Ca(v)2.1 dysfunction.