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Kv12.3potassium voltage-gated channel, subfamily H (eag-related), member 4 IntroductionsKCNH4 encodes Kv12.3 (also known as BEC2; ELK1), a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. http://www.ncbi.nlm.nih.gov/gene/23415 GenesSee figure 2 in Gutman [606] for a phylogenetic tree. Kcnh4 : potassium voltage-gated channel, subfamily H (eag-related), member 4
Ontologies
InteractionsBa2+Ba2+ blocks Kv12.3. [809] KCNH8Coexpression of KCNH8 with dominant-negative KCNH8, KCNH3, and KCNH4 subunits led to suppression of the KCNH8 currents, suggesting that Elk channels can form heteromultimers. [808] pH
Tau protein and KCNH4 mRNA levelsOverexpression of tau protein lead to the reduction of KCNH4 mRNA levels in mouse neuroplastoma cells [2087]and human neuroplastoma cells [2088] ProteinsStructuresThere are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively. [606] DistributionsExpressionsFunctionalsKineticsKv12.3 is a slowly activating voltage-gated potassium channel with threshold for activation at 90 mV [809]. ModelsReferences
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