potassium voltage-gated channel, subfamily H (eag-related), member 4 Synonyms: Kv12.3. Symbol: Kcnh4
KCNH4 encodes Kv12.3 (also known as BEC2; ELK1), a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.
See figure 2 in Gutman  for a phylogenetic tree.
Kcnh4 : potassium voltage-gated channel, subfamily H (eag-related), member 4
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
KCNH8 with dominant-negative KCNH8, KCNH3, and
KCNH4 subunits led to suppression of the KCNH8 currents,
suggesting that Elk channels can form heteromultimers. 
Kv10.2, Kv12.2, and Kv12.3 are similarly modulated by external pH. Thus high pH sensitivity has now been observed for six of eight mammalian EAG superfamily orthologues, including all members of the Eag and Elk gene families. The Erg family channels Kv11.2 and Kv11.3 have not yet been examined for pH sensitivity, but they also have the EAG-specific acidic residues 
Tau protein and KCNH4 mRNA levels
Overexpression of tau protein lead to the reduction of KCNH4 mRNA levels in mouse neuroplastoma cells and human neuroplastoma cells 
There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C
terminus, respectively. 
ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP 
Ovarian Cancer influenced by Angiogenesis
MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX) 
Kv12.3 is a slowly activating voltage-gated potassium channel with
threshold for activation at 90 mV .