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Kv12.3

potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: Kv12.3. Symbol: Kcnh4

Introductions


KCNH4 encodes Kv12.3 (also known as BEC2; ELK1), a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.

http://www.ncbi.nlm.nih.gov/gene/23415

Genes


See figure 2 in Gutman [606] for a phylogenetic tree.

Kcnh4 : potassium voltage-gated channel, subfamily H (eag-related), member 4

RGD ID Chromosome Position Species
621415 10 89677981-89697799 Rat
1607166 - Mouse
733889 17 40308910-40333296 Human

Transcripts


Acc No Sequence Length Source
NM_053630 NCBI
NM_012285 NCBI

Ontologies


Accession Name Definition Evidence
GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA
GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA

Interactions


Ba2+

Ba2+ blocks Kv12.3. [809]

KCNH8

Coexpression of KCNH8 with dominant-negative KCNH8, KCNH3, and KCNH4 subunits led to suppression of the KCNH8 currents, suggesting that Elk channels can form heteromultimers. [808]

pH

Kv.12.3 Kv10.2, Kv12.2, and Kv12.3 are similarly modulated by external pH. Thus high pH sensitivity has now been observed for six of eight mammalian EAG superfamily orthologues, including all members of the Eag and Elk gene families. The Erg family channels Kv11.2 and Kv11.3 have not yet been examined for pH sensitivity, but they also have the EAG-specific acidic residues [1832]

Tau protein and KCNH4 mRNA levels

Overexpression of tau protein lead to the reduction of KCNH4 mRNA levels in mouse neuroplastoma cells [2087]and human neuroplastoma cells [2088]

Proteins


Structures


There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively. [606]

Distributions


Expressions


Brain (telencephalon),[809], [810] neuroblastoma, esophagus, oligodendroglioma, lung, primary B-cell neoplasia, cerebellum, pituitary gland [795].

Functionals


Kinetics


Kv12.3 is a slowly activating voltage-gated potassium channel with threshold for activation at 90 mV [809].

Models


References


[604 : 20628086]
[606 : 16382104]
[810 : 10455180]
[808 : 12890647]
[809 : 9824707]
[327 : 11425889]
[795 : 10718922]
[1760 : 24719561]
[1761 : 24680769]
[1832 : 23712551]
[2087 : 25590133]
[2088 : 26576773]

Credits