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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.

Xiaofei Zhang, Federica Bertaso, Jong W Yoo, Karsten Baumgärtel, Sinead M Clancy, Van Lee, Cynthia Cienfuegos, Carly Wilmot, Jacqueline Avis, Truc Hunyh, Catherine Daguia, Christian Schmedt, Jeffrey Noebels, Timothy Jegla

Nat. Neurosci., 2010 Sep , 13, 1056-8

We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.

http://www.ncbi.nlm.nih.gov/pubmed/20676103