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Kir4.2

potassium inwardly-rectifying channel, subfamily J, member 15
Synonyms: Kir4.2 kcnj15 irkk. Symbol: Kcnj15

Introductions


Genes


Kcnj15 : potassium inwardly-rectifying channel, subfamily J, member 15

RGD ID Chromosome Position Species
621662 11 35577083-35594291 Rat
731051 16 95479258-95521867 Mouse
731050 21 39628664-39673748 Human

Transcripts


Acc No Sequence Length Source
NM_133321 NCBI
NM_019664 NCBI
NM_001039057 NCBI
NM_001039056 NCBI
NM_002243 NCBI
NM_170736 NCBI
NM_170737 NCBI

Ontologies


Accession Name Definition Evidence
GO:0005925 focal adhesion Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. IEA
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA
GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IDA

Interactions


Kir4.2 current in Xenopus oocytes can be blocked by Ba+ and Cs+ and weakly blocked by TEA in a voltage-dependent fashion. Intracellular acidification decreased mKir4.2 current in a reversible fashion, while activation of protein kinase C decreased mKir4.2 current in a manner that was not rapidly reversible. Incubation of oocytes in elevated [K+] produced a slowly developing enhancement of current.(Pearson [205])

Kir4.2 can form functional homotetramers, or heterotetramers with Kir5.1. (Pearson [205]) Kir5.1 converts Kir4.2 from a strong to a weak rectifier, rendering it sensitive to pHi, and suggesting that Kir5.1 plays a role in fine-tuning Kir4.2 activity. (Lam [206])

Proteins


Structures


The residues involved in pHi sensing in Kir channels, such as the Inner Helix acidic residues (Xu [1035] and the ‘RKR triad’ (Schulte [1036], are identical in Kir4.1 and Kir4.2. (Lam [206]

Distributions


Expressions


Kir4.2 channels are expressed in a variety of transporting epithelial within the kidney (Gosset [1028], Lourdel [1029], Shuck [1030], Tucker [1021]), liver (Hill [1031], Glowatzki [1032]), pancreas (Pessias [3]), bladder, stomach and lung (Thiery [1033], and an airway mucosal cell line (Wu [1034]).

Functionals


Kinetics


mKir4.2 expressed in Xenopus oocytes displayed a large inwardly rectifying K+ current with inward rectification being intermediate between that of the strong inward rectifier Kir2.1 and the weak inward rectifier Kir1.1. (Pearson [205])

Models


References


[205 : 9882736]
[206 : 16949552]
[1028 : 9299242]
[1029 : 11790808]
[1030 : 8995301]
[1021 : 10764726]
[1031 : 11804844]
[1032 : 7568278]
[1020 : 11306656]
[1033 : 10906485]
[1034 : 15328350]
[1035 : 11034617]
[1036 : 10611379]

Credits