Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Kir4.2 current in Xenopus oocytes can be blocked by Ba+ and Cs+ and weakly blocked by
TEA in a voltage-dependent fashion.
acidification decreased mKir4.2 current in a reversible fashion, while activation of protein
kinase C decreased mKir4.2 current in a manner that was not rapidly reversible. Incubation
of oocytes in elevated [K+] produced a slowly developing enhancement of current.(Pearson )
Kir4.2 can form
functional homotetramers, or heterotetramers with Kir5.1. (Pearson )
Kir5.1 converts Kir4.2 from a strong to a weak rectifier,
rendering it sensitive to pHi, and suggesting that Kir5.1 plays a role in fine-tuning Kir4.2 activity. (Lam )
The residues involved in
pHi sensing in Kir channels, such as the Inner Helix acidic
residues (Xu  and the ‘RKR triad’ (Schulte , are identical in Kir4.1
and Kir4.2. (Lam 
Kir4.2 channels are expressed in a variety of transporting
epithelial within the kidney (Gosset , Lourdel , Shuck , Tucker ), liver (Hill , Glowatzki ), pancreas
(Pessias ), bladder, stomach and lung (Thiery , and an airway mucosal
cell line (Wu ).
mKir4.2 expressed in Xenopus oocytes displayed a large inwardly
rectifying K+ current
with inward rectification being intermediate between that of the strong inward rectifier Kir2.1 and the weak inward rectifier Kir1.1. (Pearson )