User Visitor Login
/images/graph_sv_i.gif
English only
EPFL > FSV > BBP > Channelpedia
Ion channels
References
Reports
SEARCH IN WIKI
Logged in as a Visitor.

Kv6.2

potassium voltage-gated channel, subfamily G, member 2
Synonyms: Kv6.2 kcng2. Symbol: Kcng2

Introductions


Kv6.2 is also known as KCNF2. It is a member of subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization.

http://www.ncbi.nlm.nih.gov/gene/26251

Genes


Kcng2 : potassium voltage-gated channel, subfamily G, member 2

RGD ID Chromosome Position Species
1309521 18 77190051-77258811 Rat
1614140 18 80491283-80560993 Mouse
1319904 18 77623668-77659816 Human

Transcripts


Acc No Sequence Length Source
NM_001107372 NCBI
NM_001190373 NCBI
NM_012283 NCBI

Ontologies


Accession Name Definition Evidence

Interactions


Kv2.1/Kv6.2 channels display submicromolar sensitivity to the antiarrhythmic drug propafenone. [661]

Proteins


Structures


Yeast two-hybrid reporter assays indicated that Kv6.2 amino-termini are able to interact specifically with the Kv2.1 amino-terminus. It is proposed that this protein protein interaction underlies Kv2.1/Kv6.2 subunit assembly and the expression of functional heteromultimeric Kv2.1/Kv6.2 channels. [661]

Distributions


Expressions


Kv6.2 Expressed in Heart

Kv6.2 mRNA is preferentially expressed in rat and human myocard. [661]

Kv6.2 Expressed in Rat Brain

According to the Mus musculus potassium voltage-gated channel, subfamily G, member 2 (Kcng2) mRNA expression as been seen in the visual cortex (http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=mouse&q=Kcng2 )

Functionals


Rat and human Kv6.2 subunits appear to be unable to form functional Kv channels in a heterologous expression system, but, when coexpressed with Kv2.1 alpha subunits, heteromultimeric Kv channels were formed mediating voltage-activated delayed-rectifier type outward currents. [661]

Delayed-rectifier type channels containing Kv6.2 subunits may contribute to cardiac action potential repolarization. [661]

Kinetics


Kv6.1

Rat and human Kv6.2 subunits appear to be unable to form functional Kv channels in a heterologous expression system, but, when coexpressed with Kv2.1 alpha subunits, heteromultimeric Kv channels were formed mediating voltage-activated delayed-rectifier type outward currents. Their kinetics and conductance-voltage relationship were different from those mediated by homomultimeric Kv2.1 channels [661]

Effects of heteromerization with Kv6 subunits on the time course of inactivation of Kv2. 1 channels

Kv1.1 structure Co-expression of Kv6 with Kv2.1 Subunits—Kv6.x and/or Kv2.1 subunits were expressed in CHO-K1 cells and the amplitude and kinetics of the resulting currents were analyzed with the whole cell patch-clamp technique. Expression of Kv6.1, Kv6.3, or Kv6.4 subunits alone did not produce any voltage-dependent K+ current (not illustrated), confirming that these subunits are silent. To test for possible formation of heteromeric Kv6.x/Kv2.1 channels we then co-expressed Kv6.1, Kv6.3, or Kv6.4 subunits with Kv2.1 using an IRES-based expression vector in which the transcription of both channel subunits was under the control of the same promoter. This vector induced the translation of two open reading frames from one mRNA transcript. However, the translation of the second open reading frame (Kv2.1) was about 10-fold lower than that of the first one (Kv6), which minimized the formation of homomeric Kv2.1 channels. The time course of inactivation of the heteromeric channels was much slower than that of homotetrameric Kv2.1 channels [1708]

Models


References


[312 : 8183366]
[398 : 9696692]
[649 : 2112229]
[651 : 8987734]
[652 : 8647284]
[653 : 7682292]
[654 : 7522482]
[655 : 7522325]
[656 : 8626431]
[661 : 10551266]
[1708 : 16096342]

Credits


Editor : Admin.

Contributors : Rajnish Ranjan, Michael Schartner

To cite : [Editor], [Contributors]. Accessed on [Date] Channelpedia , http://channelpedia.epfl.ch/ionchannels/20