PubMed 25220706

Title: Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity.

Authors: Benjamin Siddoway, Hailong Hou, Jinnan Yang, Lu Sun, Hongtian Yang, Guo-Yong Wang, Houhui Xia

Journal, date & volume: Neurosci. Lett., 2014 Nov 7 , 583, 142-7

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The functional stability of neurons in the face of large variations in both activity and efficacy of synaptic connections suggests that neurons possess intrinsic negative feedback mechanisms to balance and tune excitability. While NMDA receptors have been established to play an important role in glutamate receptor-dependent plasticity through protein dephosphorylation, the effects of synaptic activation on intrinsic excitability are less well characterized. We show that increases in synaptic activity result in dephosphorylation of the potassium channel subunit Kv2.1. This dephosphorylation is induced through NMDA receptors and is executed through protein phosphatase-1 (PP1), an enzyme previously established to play a key role in regulating ligand gated ion channels in synaptic plasticity. Dephosphorylation of Kv2.1 by PP1 in response to synaptic activity results in substantial shifts in the inactivation curve of IK, resulting in a reduction in intrinsic excitability, facilitating negative feedback to neuronal excitability.