Cav3.2
Description: calcium channel, voltage-dependent, T type, alpha 1H subunit Gene: Cacna1h Synonyms: cacna1h, cav3.2, ca3.2, Ca(v)3.2
Introduction
Cav3.2 is a T type, low voltage activated (LVA) calcium channel found in neurons and many other tissues. It is also known as a1H.
Gene
GeneID: 257648 Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Rattus norvegicus ]
Transcript
Acc No | Sequence | Length | Source | |
---|---|---|---|---|
NM_153814 | n/A | n/A | NCBI | |
NM_001163691 | n/A | n/A | NCBI | |
NM_021415 | n/A | n/A | NCBI | |
NM_001005407 | n/A | n/A | NCBI | |
NM_021098 | n/A | n/A | NCBI |
Ontology
Accession | Name | Definition | Evidence | |||||||
---|---|---|---|---|---|---|---|---|---|---|
GO:0043204 | perikaryon | The portion of the cell soma (cell body) that excludes the nucleus. | IDA | |||||||
GO:0005634 | nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | IDA | |||||||
GO:0005737 | cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IDA | |||||||
GO:0005886 | plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | IMP | |||||||
GO:0016021 | integral to membrane | Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. | IEA | |||||||
GO:0030425 | dendrite | A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. | IDA | |||||||
GO:0016020 | membrane | Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. | IEA |
Interaction
Protein
Structure
Distribution
Expression
Functional
Kinetics
Model
References
108
Vitko I
et al.
Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.
J. Neurosci.,
2005
May
11
, 25 (4844-55).
109
Ohkubo T
et al.
Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus.
Cell. Physiol. Biochem.,
2005
, 16 (245-54).
110
Kaku T
et al.
The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels.
Jpn. J. Physiol.,
2003
Jun
, 53 (165-72).
111
Autret L
et al.
The involvement of Cav3.2/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones.
J. Physiol. (Lond.),
2005
Aug
15
, 567 (67-78).
103
Traboulsie A
et al.
Subunit-specific modulation of T-type calcium channels by zinc.
J. Physiol. (Lond.),
2007
Jan
1
, 578 (159-71).
Credits
Contributors: Rajnish Ranjan, Michael Schartner
To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/86/ , accessed on [date]