Cav3.2

Description: calcium channel, voltage-dependent, T type, alpha 1H subunit
Gene: Cacna1h Synonyms: cacna1h, cav3.2, ca3.2, Ca(v)3.2

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Introduction

Cav3.2 is a T type, low voltage activated (LVA) calcium channel found in neurons and many other tissues. It is also known as a1H.

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Gene

GeneID: 257648 Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Rattus norvegicus ]

RGD ID	Chromosome	Position	Species
68943	10	14621372-14679051	Rat
68994	17	25511232-25570728	Mouse
68993	16	1203241-1271772	Human

Cacna1h : calcium channel, voltage-dependent, T type, alpha 1H subunit

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Transcript

Acc No	Sequence	Length	Source
NM_153814	n/A	n/A	NCBI
NM_001163691	n/A	n/A	NCBI
NM_021415	n/A	n/A	NCBI
NM_001005407	n/A	n/A	NCBI
NM_021098	n/A	n/A	NCBI

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Ontology

Accession	Name	Definition	Evidence
GO:0043204	perikaryon	The portion of the cell soma (cell body) that excludes the nucleus.	IDA
GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	IMP
GO:0016021	integral to membrane	Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.	IEA
GO:0030425	dendrite	A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.	IDA
GO:0016020	membrane	Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.	IEA

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Interaction

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Protein

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Structure

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Distribution

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Expression

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Functional

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Kinetics

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Model

References

108

Vitko I et al. Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.
J. Neurosci., 2005 May 11 , 25 (4844-55).

109

Ohkubo T et al. Identification and electrophysiological characteristics of isoforms of T-type calcium channel Ca(v)3.2 expressed in pregnant human uterus.
Cell. Physiol. Biochem., 2005 , 16 (245-54).

110

Kaku T et al. The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels.
Jpn. J. Physiol., 2003 Jun , 53 (165-72).

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Autret L et al. The involvement of Cav3.2/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones.
J. Physiol. (Lond.), 2005 Aug 15 , 567 (67-78).

103

Traboulsie A et al. Subunit-specific modulation of T-type calcium channels by zinc.
J. Physiol. (Lond.), 2007 Jan 1 , 578 (159-71).

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Credits

Contributors: Rajnish Ranjan, Michael Schartner

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/86/ , accessed on [date]