HCN3
Description: hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Gene: Hcn3 Synonyms: HCN3, Hac3, Hcn4, Bcng4, BCNG-4, ih3
Introduction
Gene
Transcript
Ontology
Accession | Name | Definition | Evidence | |||||||
---|---|---|---|---|---|---|---|---|---|---|
GO:0016021 | integral to membrane | Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. | IEA | |||||||
GO:0016020 | membrane | Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. | IEA |
Interaction
Protein
Structure
Distribution
Expression
Functional
Kinetics
Model
Model HCN3 (ID=11) Edit
Animal | Mouse | |
CellType | Dorsal root ganglion | |
Age | 21 Days | |
Temperature | 0.0°C | |
Reversal | -45.0 mV | |
Ion | Hcn + | |
Ligand ion | ||
Reference | S Moosmang et. al; Eur. J. Biochem. 2001 Mar | |
mpower | 1.0 | |
m Inf | 1.0000/(1+exp((v- -96)/8.6)) | |
m Tau | 265.0000 |
References
55
Mistrik P
et al.
The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides.
J. Biol. Chem.,
2005
Jul
22
, 280 (27056-61).
56
Stieber J
et al.
Functional expression of the human HCN3 channel.
J. Biol. Chem.,
2005
Oct
14
, 280 (34635-43).
57
Moosmang S
et al.
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Eur. J. Biochem.,
2001
Mar
, 268 (1646-52).
Contributors: Rajnish Ranjan, Michael Schartner, Nitin Khanna
To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/63/ , accessed on [date]