HCN3

Description: hyperpolarization-activated cyclic nucleotide-gated potassium channel 3
Gene: Hcn3 Synonyms: HCN3, Hac3, Hcn4, Bcng4, BCNG-4, ih3

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Introduction

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Gene

RGD ID	Chromosome	Position	Species
620691	2	181224322-181237190	Rat
731813	3	88950697-88964079	Mouse
1605973	1	155247374-155259638	Human

Hcn3 : hyperpolarization-activated cyclic nucleotide-gated potassium channel 3

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Transcript

Acc No	Sequence	Length	Source
NM_053685	n/A	n/A	NCBI
NM_008227	n/A	n/A	NCBI
NM_020897	n/A	n/A	NCBI

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Ontology

Accession		Name			Definition					Evidence
GO:0016021		integral to membrane			Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.					IEA
GO:0016020		membrane			Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.					IEA

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Interaction

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Protein

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Structure

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Distribution

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Expression

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Functional

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Kinetics

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Model

Model HCN3 (ID=11) Edit

Animal	Mouse
CellType	Dorsal root ganglion
Age	21 Days
Temperature	0.0°C
Reversal	-45.0 mV
Ion	Hcn +
Ligand ion
Reference	S Moosmang et. al; Eur. J. Biochem. 2001 Mar
mpower	1.0
m Inf	1.0000/(1+exp((v- -96)/8.6))
m Tau	265.0000

MOD - xml - channelML

References

Mistrik P et al. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides.
J. Biol. Chem., 2005 Jul 22 , 280 (27056-61).

Stieber J et al. Functional expression of the human HCN3 channel.
J. Biol. Chem., 2005 Oct 14 , 280 (34635-43).

Moosmang S et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
Eur. J. Biochem., 2001 Mar , 268 (1646-52).

Edit - History

Credits

Contributors: Rajnish Ranjan, Michael Schartner, Nitin Khanna

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/63/ , accessed on [date]