Kv12.3
Description: potassium voltage-gated channel, subfamily H (eag-related), member 4 Gene: Kcnh4 Synonyms: Kv12.3
KCNH4 encodes Kv12.3 (also known as BEC2; ELK1), a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.
http://www.ncbi.nlm.nih.gov/gene/23415
Experimental data
Rat Kv12.3 gene in CHO host cell datasheet |
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Mouse Kv12.3 gene in CHO host cell
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Click for details ![]() 35 °C |
Human Kv12.3 gene in CHO host cell
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Click for details ![]() 25 °C |
Click for details ![]() 35 °C |
Gene
See figure 2 in Gutman [606] for a phylogenetic tree.
Transcript
Ontology
Accession | Name | Definition | Evidence | |||||||
---|---|---|---|---|---|---|---|---|---|---|
GO:0016021 | integral to membrane | Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. | IEA | |||||||
GO:0016020 | membrane | Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. | IEA |
Ba2+
Ba2+ blocks Kv12.3. [809]
KCNH8
Coexpression of KCNH8 with dominant-negative KCNH8, KCNH3, and KCNH4 subunits led to suppression of the KCNH8 currents, suggesting that Elk channels can form heteromultimers. [808]
pH
Kv10.2, Kv12.2, and Kv12.3 are similarly modulated by external pH. Thus high pH sensitivity has now been observed for six of eight mammalian EAG superfamily orthologues, including all members of the Eag and Elk gene families. The Erg family channels Kv11.2 and Kv11.3 have not yet been examined for pH sensitivity, but they also have the EAG-specific acidic residues [1832]
Tau protein and KCNH4 mRNA levels
Overexpression of tau protein lead to the reduction of KCNH4 mRNA levels in mouse neuroplastoma cells [2087]and human neuroplastoma cells [2088]
Protein
Structure
There are light oxygen voltage (LOV) and cyclic nucleotide binding (CNB) domains in the N and C terminus, respectively. [606]
Distribution
Expression
Brain (telencephalon),[809], [810] neuroblastoma, esophagus, oligodendroglioma, lung, primary B-cell neoplasia, cerebellum, pituitary gland [795].
Angiogenesis
ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP [1760]
Ovarian Cancer influenced by Angiogenesis
MiR-378 was overexpressed in ovarian cancer cells and tumors vs. normal ovarian epithelial cells. Overexpressing miR-378 in ovarian cancer cells altered expression of genes associated with angiogenesis (ALCAM, EHD1, ELK3, TLN1), apoptosis (RPN2, HIPK3), and cell cycle regulation (SWAP-70, LSM14A, RDX) [1761]
Kv12.3 is a slowly activating voltage-gated potassium channel with threshold for activation at 90 mV [809].
Model
References
604
Bailey SD
et al.
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
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Gutman GA
et al.
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacol. Rev.,
2005
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, 57 (473-508).
Miyake A
et al.
New ether-à-go-go K(+) channel family members localized in human telencephalon.
J. Biol. Chem.,
1999
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27
, 274 (25018-25).
Zou A
et al.
Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol.,
2003
Dec
, 285 (C1356-66).
Engeland B
et al.
Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
J. Physiol. (Lond.),
1998
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15
, 513 ( Pt 3) (647-54).
327
Saganich MJ
et al.
Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.
J. Neurosci.,
2001
Jul
1
, 21 (4609-24).
Wulfsen I
et al.
Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.
J. Neuroendocrinol.,
2000
Mar
, 12 (263-72).
1760
Heo SH
et al.
ELK3 suppresses angiogenesis by inhibiting the transcriptional activity of ETS-1 on MT1-MMP.
Int. J. Biol. Sci.,
2014
, 10 (438-47).
1761
Chan JK
et al.
MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer.
Gynecol. Oncol.,
2014
Jun
, 133 (568-74).
Kazmierczak M
et al.
External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor.
J. Gen. Physiol.,
2013
Jun
, 141 (721-35).
Li X
et al.
Overexpression of tau downregulated the mRNA levels of Kv channels and improved proliferation in N2A cells.
PLoS ONE,
2015
, 10 (e0116628).
Hu XM
et al.
The Tau-Induced Reduction of mRNA Levels of Kv Channels in Human Neuroblastoma SK-N-SH Cells.
J. Mol. Neurosci.,
2016
Feb
, 58 (306-11).
Credits
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