PubMed 8930341

Title: Sleep cycle disturbances induced by apamin, a selective blocker of Ca(2+)-activated K+ channels.

Authors: G Gandolfo, H Schweitz, M Lazdunski, C Gottesmann

Journal, date & volume: Brain Res., 1996 Oct 14 , 736, 344-7

PubMed link:

Intracerebroventricular injections of low doses of apamin, a specific blocker of a class of Ca(2+)-activated K+ channels, induced insomnia and a long-lasting suppression of deep slow sleep and paradoxical sleep. Injected animals showed a late but important rebound of paradoxical sleep. Even after the recovery of a normal sleep amount, the circadian cycle remained disturbed during all the recording duration (96 h).