Kv6.2

Description: potassium voltage-gated channel, subfamily G, member 2
Gene: Kcng2 Synonyms: Kv6.2, kcng2

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Introduction

Kv6.2 is also known as KCNF2. It is a member of subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization.

http://www.ncbi.nlm.nih.gov/gene/26251

Experimental data

Rat Kv6.2 gene in CHO host cell
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Gene

RGD ID	Chromosome	Position	Species
1309521	18	77190051-77258811	Rat
1614140	18	80491283-80560993	Mouse
1319904	18	77623668-77659816	Human

Kcng2 : potassium voltage-gated channel, subfamily G, member 2

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Transcript

Acc No	Sequence	Length	Source
NM_001107372	n/A	n/A	NCBI
NM_001190373	n/A	n/A	NCBI
NM_012283	n/A	n/A	NCBI

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Ontology

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Interaction

Kv2.1/Kv6.2 channels display submicromolar sensitivity to the antiarrhythmic drug propafenone. [661]

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Protein

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Structure

Yeast two-hybrid reporter assays indicated that Kv6.2 amino-termini are able to interact specifically with the Kv2.1 amino-terminus. It is proposed that this protein protein interaction underlies Kv2.1/Kv6.2 subunit assembly and the expression of functional heteromultimeric Kv2.1/Kv6.2 channels. [661]

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Distribution

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Expression

Kv6.2 Expressed in Heart

Kv6.2 mRNA is preferentially expressed in rat and human myocard. [661]

Kv6.2 Expressed in Rat Brain

According to the Mus musculus potassium voltage-gated channel, subfamily G, member 2 (Kcng2) mRNA expression as been seen in the visual cortex (http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=mouse&q=Kcng2 )

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Functional

Rat and human Kv6.2 subunits appear to be unable to form functional Kv channels in a heterologous expression system, but, when coexpressed with Kv2.1 alpha subunits, heteromultimeric Kv channels were formed mediating voltage-activated delayed-rectifier type outward currents. [661]

Delayed-rectifier type channels containing Kv6.2 subunits may contribute to cardiac action potential repolarization. [661]

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Kinetics

Kv6.1

Effects of heteromerization with Kv6 subunits on the time course of inactivation of Kv2. 1 channels

Co-expression of Kv6 with Kv2.1 Subunits—Kv6.x and/or Kv2.1 subunits were expressed in CHO-K1 cells and the amplitude and kinetics of the resulting currents were analyzed with the whole cell patch-clamp technique. Expression of Kv6.1, Kv6.3, or Kv6.4 subunits alone did not produce any voltage-dependent K+ current (not illustrated), confirming that these subunits are silent. To test for possible formation of heteromeric Kv6.x/Kv2.1 channels we then co-expressed Kv6.1, Kv6.3, or Kv6.4 subunits with Kv2.1 using an IRES-based expression vector in which the transcription of both channel subunits was under the control of the same promoter. This vector induced the translation of two open reading frames from one mRNA transcript. However, the translation of the second open reading frame (Kv2.1) was about 10-fold lower than that of the first one (Kv6), which minimized the formation of homomeric Kv2.1 channels. The time course of inactivation of the heteromeric channels was much slower than that of homotetrameric Kv2.1 channels [1708]