Channelpedia

Nav3.1

Description: neuron navigator 3
Gene: Nav3     Synonyms: nav3.1

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Introduction

The third family of sodium channel isoforms is represented by a single member, Nav3.1 (originally known as NaN), which is less than 50% identical to any of the type 1 or type 2 channels. And type 2 and 3 channels differ greatly from the type 1 family, suggesting that these channels have completely different roles in vivo, although any indication about their significance awaits functional expression. Goldin, 1999, [899]

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Gene

RGD ID Chromosome Position Species
1306259 7 48505502-48862109 Rat
1621252 10 109120495-109437275 Mouse
1314915 12 78225069-78606790 Human

Nav3 : neuron navigator 3

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Transcript

Acc No Sequence Length Source
NM_001191782 n/A n/A NCBI
NM_001081035 n/A n/A NCBI
NM_014903 n/A n/A NCBI
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Ontology

Accession Name Definition Evidence
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA
GO:0005635 nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). IEA
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Interaction

Nav3.1 is predicted to be resistant to nanomolar concentrations of TTX based on the presence of a serine rather than an aromatic residue at the TTX resistant site in domain I. Goldin [881]

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Protein

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Structure

The sequence of this channel is more similar to the type 1 than the type 2 family in the S4 segments and the domain III-IV linker. The number of positive charges in the S4 regions of domains I and IV are comparable to those present in type 1 channels, and the number in domains II and III are intermediate between types 1 and 2. The sequence in the domain III-IV linker includes the residues that are critical for normal inactivation. [881]

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Distribution

Kv3.1 is down-regulated after axotomy. Dib-Hajj [899].

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Expression

The Nav3.1 channel is expressed in small fibers (sensory neurons) of the DRG and trigeminal ganglion, and the level of expression is down-regulated after axotomy. The channel has not been expressed in an exogenous system yet (1999). Goldin [881]

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Functional

The complex Na current profile in DRG neurons influences their excitability [862], [900], [901], [902] and may contribute to ectopic or spontaneous firing in these cells after injury to their axons [903], [899], [861].

Changes in the Na current profile may contribute to neuropathic and inflammation-evoked pain. Dib-Hajj [899]

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Kinetics

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Model

References

881

Goldin AL Diversity of mammalian voltage-gated sodium channels.
Ann. N. Y. Acad. Sci., 1999 Apr 30 , 868 (38-50).

900

Honmou O et al. Delayed depolarization and slow sodium currents in cutaneous afferents.
J. Neurophysiol., 1994 May , 71 (1627-37).

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Credits

To cite this page: [Contributors] Channelpedia https://channelpedia.epfl.ch/ionchannels/133/ , accessed on [date]