Nav1 Channel

1

Aydar E et al. Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Eur. Biophys. J., 2016 May 9 , ().

2

Yang J et al. FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.
Channels (Austin), 2016 May 31 , (1-11).

3

Hirano-Iwata A et al. Reconstitution of Human Ion Channels into Solvent-free Lipid Bilayers Enhanced by Centrifugal Forces.
Biophys. J., 2016 May 24 , 110 (2207-15).

4

Zeng H et al. Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods, 2016 May 21 , ().

5

Rosberg MR et al. Progression of motor axon dysfunction and ectopic Nav1.8 expression in a mouse model of Charcot-Marie-Tooth disease 1B.
Neurobiol. Dis., 2016 May 20 , 93 (201-214).

6

Ali SR et al. Identification of Amino Acid Residues in Fibroblast Growth Factor 14 (FGF14) Required for Structure-Function Interactions with Voltage-gated Sodium Channel Nav1.6.
J. Biol. Chem., 2016 May 20 , 291 (11268-84).

7

Mulcahy JV et al. Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihydroxysaxitoxin.
J. Am. Chem. Soc., 2016 May 11 , 138 (5994-6001).

8

Schilling JM et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice.
Basic Res. Cardiol., 2016 May , 111 (28).

9

Cheng LJ et al. Effects of Fluvastatin on Characteristics of Stellate Ganglion Neurons in a Rabbit Model of Myocardial Ischemia.
Chin. Med. J., 2016 May , 129 (549-56).

10

Gupta B et al. Antinociceptive properties of shikonin: in vitro and in vivo studies.
Can. J. Physiol. Pharmacol., 2016 Mar 6 , (1-9).

11

Patel D et al. Computational Study of Binding of μ-Conotoxin GIIIA to Bacterial Sodium Channels NaVAb and NaVRh.
Biochemistry, 2016 Mar 29 , 55 (1929-38).

12

Tao H et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon, 2016 Mar 1 , 111 (13-21).

13

Rogers M et al. Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening.
Assay Drug Dev Technol, 2016 Mar , 14 (109-30).

14

Chambers C et al. High-Throughput Screening of NaV1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument.
Assay Drug Dev Technol, 2016 Mar , 14 (93-108).

15

Henriques ST et al. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes is a Prerequisite for its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.
J. Biol. Chem., 2016 Jun 16 , ().

16

Xu J et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level.
Fitoterapia, 2016 Jun , 111 (1-6).

17

Du Y et al. β1-Adrenergic blocker bisoprolol reverses down-regulated ion channels in sinoatrial node of heart failure rats.
J. Physiol. Biochem., 2016 Jun , 72 (293-302).

18

Arias HR et al. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.
Int. J. Biochem. Cell Biol., 2016 Jul , 76 (19-30).

19

Zaklyazminskaya E et al. The role of mutations in the SCN5A gene in cardiomyopathies.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1799-805).

20

Sottas V et al. Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1791-8).

21

Green BR et al. Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
J. Biol. Chem., 2016 Jan 27 , ().

22

Cui HL et al. Catalytic asymmetric hetero-Diels-Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives.
Org. Biomol. Chem., 2016 Jan 27 , 14 (1777-83).

23

Wang HG et al. A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.
J. Mol. Cell. Cardiol., 2016 Jan 19 , 92 (52-62).

24

Tarvin RD et al. Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.
Mol. Biol. Evol., 2016 Jan 18 , ().

25

He B et al. Effects of the β1 auxiliary subunit on modification of Rat Na(v)1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin.
Toxicol. Appl. Pharmacol., 2016 Jan 15 , 291 (58-69).

26

Habbout K et al. A recessive Nav1.4 mutation underlies congenital myasthenic syndrome with periodic paralysis.
Neurology, 2016 Jan 12 , 86 (161-9).

27

Mohammed FH et al. Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Int. J. Oncol., 2016 Jan , 48 (73-83).

28

Horvath GA et al. Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?
Mol. Genet. Metab., 2016 Jan , 117 (42-8).

29

Stueber T et al. Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.
Anesthesiology, 2016 Feb 9 , ().

30

Han C et al. Sodium channel Nav1.8: Emerging links to human disease.
Neurology, 2016 Feb 2 , 86 (473-83).

31

Roostaei T et al. Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.
Neurology, 2016 Feb 2 , 86 (410-7).

32

Murray JK et al. Single Residue Substitutions That Confer NaV Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.
J. Med. Chem., 2016 Feb 18 , ().

33

Benned-Jensen T et al. Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed.
J. Neurosci., 2016 Feb 17 , 36 (2261-6).

34

Kim KX et al. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function.
J. Neurosci., 2016 Feb 17 , 36 (2111-8).

35

Poulet C et al. Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillation.
Physiol Rep, 2016 Feb , 4 ().

36

Ye P et al. Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain.
Acta Biochim. Biophys. Sin. (Shanghai), 2016 Feb , 48 (132-44).

37

Murenzi E et al. Evaluation of microtransplantation of rat brain neurolemma into Xenopus laevis oocytes as a technique to study the effect of neurotoxicants on endogenous voltage-sensitive ion channels.
Neurotoxicology, 2016 Apr 7 , ().

38

Crumb WJ et al. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
J Pharmacol Toxicol Methods, 2016 Apr 6 , ().

39

Branch SY et al. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease.
J. Neurosci., 2016 Apr 6 , 36 (4026-37).

40

Shcherbatko A et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem., 2016 Apr 22 , ().

41

Frost JM et al. Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
J. Med. Chem., 2016 Apr 14 , 59 (3373-91).

42

Nassal DM et al. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.
PLoS ONE, 2016 , 11 (e0146561).

43

Zhang H et al. Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.
Elife, 2016 , 5 ().

44

Lazcano-Pérez F et al. Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons.
Toxins (Basel), 2016 , 8 ().

45

Kubanek J et al. Ultrasound modulates ion channel currents.
Sci Rep, 2016 , 6 (24170).

46

Choi JI et al. α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
PLoS ONE, 2016 , 11 (e0152355).

47

Alshammari MA et al. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
Front Cell Neurosci, 2016 , 10 (5).

48

Leo-Macias A et al. Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.
Nat Commun, 2016 , 7 (10342).

49

Wang X et al. Characterization of Specific Roles of Sodium Channel Subtypes in Regional Anesthesia.
Reg Anesth Pain Med, 2015 Sep-Oct , 40 (599-604).

50

Eberhardt E et al. Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.
Stem Cell Reports, 2015 Sep 8 , 5 (305-13).

51

Ji RR Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?
Pulm Pharmacol Ther, 2015 Sep 6 , ().

52

Salas MM et al. Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in a rat full thickness thermal injury pain model.
Neurosci. Lett., 2015 Sep 28 , 607 (108-113).

53

Nutter TJ et al. A delayed chronic pain like condition with decreased Kv channel activity in a rat model of Gulf War Illness pain syndrome.
Neurotoxicology, 2015 Sep 26 , 51 (67-79).

54

Remacle AG et al. Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling.
J. Biol. Chem., 2015 Sep 18 , 290 (22939-44).

55

Neshatian L et al. Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Sep 15 , 309 (G506-12).

56

Kurowski P et al. Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats.
Neuroscience, 2015 Sep 10 , 303 (474-88).

57

Dib-Hajj SD et al. NaV1.9: a sodium channel linked to human pain.
Nat. Rev. Neurosci., 2015 Sep , 16 (511-9).

58

Aktas CC et al. In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.
Acta Biochim. Biophys. Sin. (Shanghai), 2015 Sep , 47 (680-6).

59

Li G et al. Positive shift of Nav1.8 current inactivation curve in injured neurons causes neuropathic pain following chronic constriction injury.
Mol Med Rep, 2015 Sep , 12 (3583-90).

60

Namer B et al. Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Nav1.7.
Pain, 2015 Sep , 156 (1637-46).

61

Estacion M et al. Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.
J. Neurophysiol., 2015 Sep , 114 (1554-64).

62

Musa H et al. SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Proc. Natl. Acad. Sci. U.S.A., 2015 Oct 6 , 112 (12528-33).

63

Endo R et al. Carvedilol Suppresses Apoptosis and Ion Channel Remodelling of HL-1 Cardiac Myocytes Expressing E334K cMyBPC.
Drug Res (Stuttg), 2015 Oct 19 , ().

64

Hao W et al. Design, synthesis and structure-activity relationship of indoxacarb analogs as voltage-gated sodium channel blocker.
Bioorg. Med. Chem. Lett., 2015 Oct 15 , 25 (4576-9).

65

Patel R et al. Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera.
Eur. J. Neurosci., 2015 Oct 10 , ().

66

Klint JK et al. Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target NaV1.7.
Mol. Pharmacol., 2015 Oct 1 , ().

67

Nicole S et al. Skeletal muscle sodium channelopathies.
Curr. Opin. Neurol., 2015 Oct , 28 (508-514xs).

68

Detta N et al. The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.
Biochim. Biophys. Acta, 2015 Oct , 1854 (1502-9).

69

Torbergsen T et al. Painful cramps and giant myotonic discharges in a family with the Nav1.4-G1306A mutation.
Muscle Nerve, 2015 Oct , 52 (680-3).

70

Murray JK et al. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Bioorg. Med. Chem. Lett., 2015 Nov 1 , 25 (4866-71).

71

Zheng G et al. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways.
Exp. Neurol., 2015 Nov , 273 (301-11).

72

Gawali VS et al. Mechanism of Modification, by Lidocaine, of Fast and Slow Recovery from Inactivation of Voltage-Gated Na⁺ Channels.
Mol. Pharmacol., 2015 Nov , 88 (866-79).

73

Liu C et al. Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
J. Biol. Chem., 2015 May 8 , 290 (12048-57).

74

Hamada MS et al. Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability.
J. Neurosci., 2015 May 6 , 35 (7272-86).

75

Han Z et al. The effects of A-803467 on cardiac Nav1.5 channels.
Eur. J. Pharmacol., 2015 May 5 , 754 (52-60).

76

Lu VB et al. A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal.
J. Neurosci., 2015 May 20 , 35 (8021-34).

77

Emery EC et al. Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.
J. Neurosci., 2015 May 20 , 35 (7674-81).

78

Lolignier S et al. The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.
Cell Rep, 2015 May 19 , 11 (1067-78).

79

Zhu JF et al. Novel heterozygous mutation c.4282G>T in the SCN5A gene in a family with Brugada syndrome.
Exp Ther Med, 2015 May , 9 (1639-1645).

80

Chahine M Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.
Future Cardiol, 2015 May , 11 (287-91).

81

Kalume F et al. Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.
Neurobiol. Dis., 2015 May , 77 (141-54).

82

Marionneau C et al. Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J. Mol. Cell. Cardiol., 2015 May , 82 (36-47).

83

Tsai MS et al. Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.
Neurobiol. Dis., 2015 May , 77 (35-48).

84

Blanchard MG et al. De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy.
J. Med. Genet., 2015 May , 52 (330-7).

85

Wildburger NC et al. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.
Mol. Cell Proteomics, 2015 May , 14 (1288-300).

86

Liu GX et al. Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.
Heart Rhythm, 2015 May , 12 (1036-45).

87

Woods CG et al. The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P.
Eur. J. Hum. Genet., 2015 May , 23 (561-3).

88

Stadler T et al. Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7.
J. Biol. Chem., 2015 Mar 6 , 290 (6316-25).

89

Tan BY et al. A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore.
Europace, 2015 Mar 31 , ().

90

Han C et al. Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.
J. Neurophysiol., 2015 Mar 18 , (jn.00113.2015).

91

Mishra S et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).

92

Murray JK et al. Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel.
J. Med. Chem., 2015 Mar 12 , 58 (2299-314).

93

Ossola D et al. Force-controlled patch clamp of beating cardiac cells.
Nano Lett., 2015 Mar 11 , 15 (1743-50).

94

Tigerholm J et al. C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability.
Biophys. J., 2015 Mar 10 , 108 (1057-71).

95

Gazina EV et al. 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.
Hum. Mol. Genet., 2015 Mar 1 , 24 (1457-68).

96

Kong W et al. SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability.
Epilepsia, 2015 Mar , 56 (431-8).

97

Yan Z et al. Expression and functional role of Nav1.9 sodium channel in cartwheel cells of the dorsal cochlear nucleus.
Mol Med Rep, 2015 Mar , 11 (1833-6).

98

Bechi G et al. Rescuable folding defective NaV1.1 (SCN1A) mutants in epilepsy: properties, occurrence, and novel rescuing strategy with peptides targeted to the endoplasmic reticulum.
Neurobiol. Dis., 2015 Mar , 75 (100-14).

99

Rahman W et al. Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat.
Neuroscience, 2015 Jun 4 , 295 (103-16).

100

Zhang MM et al. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.
Biochemistry, 2015 Jun 30 , 54 (3911-20).

101

Hoeijmakers JG et al. Painful peripheral neuropathy and sodium channel mutations.
Neurosci. Lett., 2015 Jun 2 , 596 (51-9).

102

Du Y et al. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling.
ACS Chem Neurosci, 2015 Jun 17 , 6 (871-8).

103

Behr ER et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.
Cardiovasc. Res., 2015 Jun 1 , 106 (520-9).

104

Mercier A et al. Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochim. Biophys. Acta, 2015 Jun , 1850 (1215-23).

105

Ye P et al. Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats.
Protein Cell, 2015 Jun , 6 (443-52).

106

Fukasawa T et al. A case of recurrent encephalopathy with SCN2A missense mutation.
Brain Dev., 2015 Jun , 37 (631-4).

107

Wannous R et al. Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
Pflugers Arch., 2015 Jun , 467 (1249-59).

108

Stroemlund LW et al. Gap junctions - guards of excitability.
Biochem. Soc. Trans., 2015 Jun , 43 (508-12).

109

Huang Y et al. Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II.
Peptides, 2015 Jun , 68 (175-82).

110

Han C et al. The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy.
Neuromolecular Med., 2015 Jun , 17 (158-69).

111

Winkel BG et al. The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Heart Rhythm, 2015 Jun , 12 (1241-9).

112

Daimi H et al. Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.
Heart Rhythm, 2015 Jun , 12 (1333-42).

113

Cai T et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides, 2015 Jun , 68 (148-56).

114

Coronas FI et al. Biochemical and physiological characterization of a new Na(+)-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus.
Peptides, 2015 Jun , 68 (11-6).

115

Xu M et al. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.
J. Biol. Chem., 2015 Jul 3 , 290 (16619-32).

116

Talbot S et al. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Neuron, 2015 Jul 15 , 87 (341-54).

117

Torregrosa R et al. Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Bioorg. Med. Chem., 2015 Jul 1 , 23 (3655-66).

118

Chow CY et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel), 2015 Jul , 7 (2494-513).

119

Slowik D et al. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
Biochim. Biophys. Acta, 2015 Jul , 1848 (1545-51).

120

Wang ZJ et al. Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions.
Acta Pharmacol. Sin., 2015 Jul , 36 (791-9).

121

Pucca MB et al. Revealing the Function and the Structural Model of Ts4: Insights into the "Non-Toxic" Toxin from Tityus serrulatus Venom.
Toxins (Basel), 2015 Jul , 7 (2534-50).

122

Wang M et al. [Dynamic expressions of Nav1.2 and Nav1.6 in hippocampal CA3 region of epileptic rats].
Zhonghua Yi Xue Za Zhi, 2015 Jan 6 , 95 (61-5).

123

Zhang J et al. Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.
Eur. J. Pharmacol., 2015 Jan 5 , 746 (333-43).

124

Chong E et al. Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation.
Heart Rhythm, 2015 Jan 30 , ().

125

Fukuoka T et al. De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation.
Neuroscience, 2015 Jan 22 , 284 (693-706).

126

Wagnon JL et al. Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.
Hum. Mol. Genet., 2015 Jan 15 , 24 (506-15).

127

Saber S et al. Complex genetic background in a large family with Brugada syndrome.
Physiol Rep, 2015 Jan 1 , 3 ().

128

Lynch SM et al. Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Bioorg. Med. Chem. Lett., 2015 Jan 1 , 25 (43-7).

129

Lynch SM et al. N-Aryl azacycles as novel sodium channel blockers.
Bioorg. Med. Chem. Lett., 2015 Jan 1 , 25 (48-52).

130

Kirchhof P et al. First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.
Circ Heart Fail, 2015 Jan , 8 (79-88).

131

Stoetzer C et al. Methadone is a local anaesthetic-like inhibitor of neuronal Na+ channels and blocks excitability of mouse peripheral nerves.
Br J Anaesth, 2015 Jan , 114 (110-20).

132

Zhang F et al. Natural mutations change the affinity of μ-theraphotoxin-Hhn2a to voltage-gated sodium channels.
Toxicon, 2015 Jan , 93 (24-30).

133

Rubinstein M et al. Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
Neurobiol. Dis., 2015 Jan , 73 (106-17).

134

Sato T et al. Glial reaction in the spinal cord of the degenerating muscle mouse (Scn8a (dmu)).
Neurochem. Res., 2015 Jan , 40 (124-9).

135

Feng B et al. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings.
J. Neurophysiol., 2015 Feb 4 , (jn.00717.2014).

136

Larsen J et al. The phenotypic spectrum of SCN8A encephalopathy.
Neurology, 2015 Feb 3 , 84 (480-9).

137

Vandael DH et al. Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells.
J. Physiol. (Lond.), 2015 Feb 15 , 593 (905-27).

138

Moreau A et al. Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.
J. Gen. Physiol., 2015 Feb , 145 (93-106).

139

Beltran-Alvarez P et al. Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel.
Amino Acids, 2015 Feb , 47 (429-34).

140

Ednie AR et al. Sialic acids attached to N- and O-glycans within the Nav1.4 D1S5-S6 linker contribute to channel gating.
Biochim. Biophys. Acta, 2015 Feb , 1850 (307-17).

141

Zhang H et al. Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.
Mol. Pharmacol., 2015 Feb , 87 (207-17).

142

Suter MR et al. p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder.
Anesthesiology, 2015 Feb , 122 (414-23).

143

Bi RY et al. A new hypothesis of sex-differences in temporomandibular disorders: estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion?
Med. Hypotheses, 2015 Feb , 84 (100-3).

144

Jabbari J et al. Common and rare variants in SCN10A modulate the risk of atrial fibrillation.
Circ Cardiovasc Genet, 2015 Feb , 8 (64-73).

145

Tikhonov DB et al. State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.
Pflugers Arch., 2015 Feb , 467 (253-66).

146

Teramoto N et al. Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects.
Mar Drugs, 2015 Feb , 13 (984-95).

147

Zhu W et al. Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry.
Prog. Biophys. Mol. Biol., 2015 Dec 25 , ().

148

Obergrussberger A et al. Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module.
J Lab Autom, 2015 Dec 23 , ().

149

Zaharieva IT et al. Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or 'classical' congenital myopathy.
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