Channelpedia

Aydar E et al. Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Eur. Biophys. J., 2016 May 9 , ().

Yang J et al. FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.
Channels (Austin), 2016 May 31 , (1-11).

Hirano-Iwata A et al. Reconstitution of Human Ion Channels into Solvent-free Lipid Bilayers Enhanced by Centrifugal Forces.
Biophys. J., 2016 May 24 , 110 (2207-15).

Zeng H et al. Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods, 2016 May 21 , ().

Schilling JM et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice.
Basic Res. Cardiol., 2016 May , 111 (28).

Daumy X et al. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I.
Int. J. Cardiol., 2016 Mar 15 , 207 (349-58).

Tao H et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon, 2016 Mar 1 , 111 (13-21).

Zhao Y et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.
Int. J. Mol. Med., 2016 Jun , 37 (1511-20).

Zaklyazminskaya E et al. The role of mutations in the SCN5A gene in cardiomyopathies.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1799-805).

Sottas V et al. Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1791-8).

Van Driest SL et al. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
JAMA, 2016 Jan 5 , 315 (47-57).

Wang HG et al. A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.
J. Mol. Cell. Cardiol., 2016 Jan 19 , 92 (52-62).

Mohammed FH et al. Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Int. J. Oncol., 2016 Jan , 48 (73-83).

Neubauer J et al. Post-mortem whole-exome sequencing (WES) with a focus on cardiac disease-associated genes in five young sudden unexplained death (SUD) cases.
Int. J. Legal Med., 2016 Feb 4 , ().

Poulet C et al. Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillation.
Physiol Rep, 2016 Feb , 4 ().

Crumb WJ et al. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
J Pharmacol Toxicol Methods, 2016 Apr 6 , ().

Shcherbatko A et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem., 2016 Apr 22 , ().

Nassal DM et al. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.
PLoS ONE, 2016 , 11 (e0146561).

Zhao Y et al. Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells.
BMC Cardiovasc Disord, 2016 , 16 (1).

Portero V et al. Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome.
J Am Heart Assoc, 2016 , 5 ().

Kubanek J et al. Ultrasound modulates ion channel currents.
Sci Rep, 2016 , 6 (24170).

Choi JI et al. α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
PLoS ONE, 2016 , 11 (e0152355).

Leo-Macias A et al. Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.
Nat Commun, 2016 , 7 (10342).

Hertz CL et al. Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases.
Eur. J. Hum. Genet., 2015 Sep 9 , ().

Eberhardt E et al. Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.
Stem Cell Reports, 2015 Sep 8 , 5 (305-13).

Climent AM et al. The Role of Atrial Tissue Remodeling on Rotor Dynamics: An In-Vitro Study.
Am. J. Physiol. Heart Circ. Physiol., 2015 Sep 25 , (ajpheart.00055.2015).

Neshatian L et al. Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Sep 15 , 309 (G506-12).

Abdelsayed M et al. Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants.
J. Physiol. (Lond.), 2015 Sep 15 , 593 (4201-23).

Berghuis B et al. Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy.
Epilepsy Res., 2015 Sep , 115 (141-4).

Aktas CC et al. In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.
Acta Biochim. Biophys. Sin. (Shanghai), 2015 Sep , 47 (680-6).

Farrugia A et al. Targeted next generation sequencing application in cardiac channelopathies: Analysis of a cohort of autopsy-negative sudden unexplained deaths.
Forensic Sci. Int., 2015 Sep , 254 (5-11).

Musa H et al. SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Proc. Natl. Acad. Sci. U.S.A., 2015 Oct 6 , 112 (12528-33).

Nunn LM et al. Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing.
Europace, 2015 Oct 25 , ().

Endo R et al. Carvedilol Suppresses Apoptosis and Ion Channel Remodelling of HL-1 Cardiac Myocytes Expressing E334K cMyBPC.
Drug Res (Stuttg), 2015 Oct 19 , ().

Beyder A et al. Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.
Neurogastroenterol. Motil., 2015 Oct 13 , ().

Detta N et al. The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.
Biochim. Biophys. Acta, 2015 Oct , 1854 (1502-9).

Chiang DY et al. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1105-12).

Murray JK et al. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Bioorg. Med. Chem. Lett., 2015 Nov 1 , 25 (4866-71).

Han Z et al. The effects of A-803467 on cardiac Nav1.5 channels.
Eur. J. Pharmacol., 2015 May 5 , 754 (52-60).

Le Scouarnec S et al. Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome.
Hum. Mol. Genet., 2015 May 15 , 24 (2757-63).

Chahine M Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.
Future Cardiol, 2015 May , 11 (287-91).

Zhu JF et al. Novel heterozygous mutation c.4282G>T in the SCN5A gene in a family with Brugada syndrome.
Exp Ther Med, 2015 May , 9 (1639-1645).

Marionneau C et al. Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J. Mol. Cell. Cardiol., 2015 May , 82 (36-47).

Liu GX et al. Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.
Heart Rhythm, 2015 May , 12 (1036-45).

Tan BY et al. A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore.
Europace, 2015 Mar 31 , ().

Mishra S et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).

Murray JK et al. Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel.
J. Med. Chem., 2015 Mar 12 , 58 (2299-314).

Ossola D et al. Force-controlled patch clamp of beating cardiac cells.
Nano Lett., 2015 Mar 11 , 15 (1743-50).

Liang W et al. Wnt signalling suppresses voltage-dependent Na(+) channel expression in postnatal rat cardiomyocytes.
J. Physiol. (Lond.), 2015 Mar 1 , 593 (1147-57).

De Filippo P et al. Cavotricuspid isthmus ablation and subcutaneous monitoring device implantation in a 2-year-old baby with 2 SCN5A mutations, sinus node dysfunction, atrial flutter recurrences, and drug induced long-QT syndrome: a tricky case of pediatric overlap syndrome?
J. Cardiovasc. Electrophysiol., 2015 Mar , 26 (346-9).

Hayashi K et al. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.
Circ Arrhythm Electrophysiol, 2015 Jun 30 , ().

Behr ER et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.
Cardiovasc. Res., 2015 Jun 1 , 106 (520-9).

Mercier A et al. Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochim. Biophys. Acta, 2015 Jun , 1850 (1215-23).

Wannous R et al. Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
Pflugers Arch., 2015 Jun , 467 (1249-59).

Stroemlund LW et al. Gap junctions - guards of excitability.
Biochem. Soc. Trans., 2015 Jun , 43 (508-12).

Nikulina SY et al. An investigation of the association of the H558R polymorphism of the SCN5A gene with idiopathic cardiac conduction disorders.
Genet Test Mol Biomarkers, 2015 Jun , 19 (288-94).

Huang Y et al. Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II.
Peptides, 2015 Jun , 68 (175-82).

Daimi H et al. Absence of family history and phenotype-genotype correlation in pediatric Brugada syndrome: more burden to bear in clinical and genetic diagnosis.
Pediatr Cardiol, 2015 Jun , 36 (1090-6).

Winkel BG et al. The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Heart Rhythm, 2015 Jun , 12 (1241-9).

Daimi H et al. Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.
Heart Rhythm, 2015 Jun , 12 (1333-42).

Cai T et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides, 2015 Jun , 68 (148-56).

Stattin EL et al. Genetic screening in sudden cardiac death in the young can save future lives.
Int. J. Legal Med., 2015 Jul 31 , ().

Watanabe H et al. Genetics of Brugada syndrome.
J. Hum. Genet., 2015 Jul 30 , ().

Torregrosa R et al. Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Bioorg. Med. Chem., 2015 Jul 1 , 23 (3655-66).

Chow CY et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel), 2015 Jul , 7 (2494-513).

Hasdemir C et al. High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.
Heart Rhythm, 2015 Jul , 12 (1584-94).

Verstraelen TE et al. The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders.
Neurogastroenterol. Motil., 2015 Jul , 27 (906-13).

Zhang J et al. Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.
Eur. J. Pharmacol., 2015 Jan 5 , 746 (333-43).

Chong E et al. Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation.
Heart Rhythm, 2015 Jan 30 , ().

Saber S et al. Complex genetic background in a large family with Brugada syndrome.
Physiol Rep, 2015 Jan 1 , 3 ().

Baruteau AE et al. Inherited progressive cardiac conduction disorders.
Curr. Opin. Cardiol., 2015 Jan , 30 (33-9).

Kirchhof P et al. First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.
Circ Heart Fail, 2015 Jan , 8 (79-88).

Park DS et al. Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J. Clin. Invest., 2015 Jan , 125 (403-12).

Wilde AA et al. Bringing home the bacon? The next step in cardiac sodium channelopathies.
J. Clin. Invest., 2015 Jan , 125 (99-101).

Hothi SS et al. p.Y1449C SCN5A mutation associated with overlap disorder comprising conduction disease, Brugada syndrome, and atrial flutter.
J. Cardiovasc. Electrophysiol., 2015 Jan , 26 (93-7).

Riuró H et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome.
Eur. J. Hum. Genet., 2015 Jan , 23 (79-85).

Huang CW et al. The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents.
Neuroscience, 2015 Feb 26 , 287 (125-36).

Schwoerer AP et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels.
Anesth. Analg., 2015 Feb 16 , ().

de Llano CT et al. Further evidence of the association between LQT syndrome and epilepsy in a family with KCNQ1 pathogenic variant.
Seizure, 2015 Feb , 25 (65-7).

Moreau A et al. Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.
J. Gen. Physiol., 2015 Feb , 145 (93-106).

Beltran-Alvarez P et al. Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel.
Amino Acids, 2015 Feb , 47 (429-34).

Zhang H et al. Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.
Mol. Pharmacol., 2015 Feb , 87 (207-17).

Zhu W et al. Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry.
Prog. Biophys. Mol. Biol., 2015 Dec 25 , ().

Peters CH et al. Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.
Prog. Biophys. Mol. Biol., 2015 Dec 20 , ().

Veerman CC et al. The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.
Gene, 2015 Dec 1 , 573 (177-87).

Qureshi SF et al. Mutational analysis of SCN5A gene in long QT syndrome.
Meta Gene, 2015 Dec , 6 (26-35).

Glynn P et al. Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.
Circulation, 2015 Aug 18 , 132 (567-77).

Varga Z et al. Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.
Circ Arrhythm Electrophysiol, 2015 Aug 17 , ().

Lo YC et al. Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells.
Br. J. Pharmacol., 2015 Aug 15 , ().

Potet F et al. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
Circ Arrhythm Electrophysiol, 2015 Aug , 8 (933-41).

Pucca MB et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie, 2015 Aug , 115 (8-16).

Kapplinger JD et al. Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
Circ Cardiovasc Genet, 2015 Aug , 8 (582-95).

Peigneur S et al. A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms.
Neuropharmacology, 2015 Apr 7 , ().

Willis BC et al. Protein Assemblies of Sodium and Inward Rectifier Potassium Channels Control Cardiac Excitability and Arrhythmogenesis.
Am. J. Physiol. Heart Circ. Physiol., 2015 Apr 10 , (ajpheart.00176.2015).

Algalarrondo V et al. Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1.
Neuromuscul. Disord., 2015 Apr , 25 (308-20).

Williams VS et al. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome.
Europace, 2015 Apr , 17 (635-41).

Iqbal SM et al. Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase.
Cell. Physiol. Biochem., 2015 , 37 (825-37).

Chang YS et al. Mutation Analysis of KCNQ1, KCNH2 and SCN5A Genes in Taiwanese Long QT Syndrome Patients.
Int Heart J, 2015 , 56 (450-3).

Yamanushi TT et al. Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy.
Folia Morphol. (Warsz), 2015 , 74 (258-61).

100

Leong IU et al. Assessment of the predictive accuracy of five in silico prediction tools, alone or in combination, and two metaservers to classify long QT syndrome gene mutations.
BMC Med. Genet., 2015 , 16 (34).

101

Nelson M et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.
Mol. Cancer, 2015 , 14 (13).

102

Obejero-Paz CA et al. Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
Sci Rep, 2015 , 5 (17623).

103

Hu RM et al. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis.
PLoS ONE, 2015 , 10 (e0124921).

104

Han Z et al. Deletion of PDK1 causes cardiac sodium current reduction in mice.
PLoS ONE, 2015 , 10 (e0122436).

105

Saito Y et al. Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
PLoS ONE, 2015 , 10 (e0138193).

106

Wang L et al. De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome.
Cell. Physiol. Biochem., 2015 , 36 (2250-62).

107

Allegue C et al. Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
PLoS ONE, 2015 , 10 (e0133037).

108

Selga E et al. Comprehensive Genetic Characterization of a Spanish Brugada Syndrome Cohort.
PLoS ONE, 2015 , 10 (e0132888).

109

Marcsa B et al. A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease.
PLoS ONE, 2015 , 10 (e0132137).

110

Poulet C et al. Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation.
PLoS ONE, 2015 , 10 (e0131432).

111

House CD et al. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Sci Rep, 2015 , 5 (11541).

112

Wang Y et al. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
PLoS ONE, 2015 , 10 (e0128653).

113

Mirams GR et al. Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
J Pharmacol Toxicol Methods, 2014 Nov-Dec , 70 (246-54).

114

Brugada R et al. Brugada syndrome.
Methodist Debakey Cardiovasc J, 2014 Jan-Mar , 10 (25-8).

115

Sällström J et al. Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: Heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.
J Pharmacol Toxicol Methods, 2014 Jan-Feb , 69 (24-9).

116

Sayeed MZ et al. Brugada syndrome with a novel missense mutation in SCN5A gene: a case report from Bangladesh.
Indian Heart J, 2014 Jan-Feb , 66 (104-7).

117

Sun S et al. The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.
Bioorg. Med. Chem. Lett., 2014 Sep 15 , 24 (4397-401).

118

Ho GD et al. Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg. Med. Chem. Lett., 2014 Sep 1 , 24 (4110-3).

119

Frenz CT et al. NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.
J. Neurophysiol., 2014 Sep 1 , 112 (1091-104).

120

Bartok A et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K(+) channels.
Toxicon, 2014 Sep , 87 (6-16).

121

van Hoeijen DA et al. Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.
Expert Opin Pharmacother, 2014 Sep , 15 (1875-87).

122

Cai B et al. Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit.
J. Mol. Cell. Cardiol., 2014 Sep , 74 (297-306).

123

Pappalardo LW et al. Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis.
Neuroreport, 2014 Oct 22 , 25 (1208-15).

124

Shi D et al. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
J. Cell. Mol. Med., 2014 Oct , 18 (1992-9).

125

Poulin H et al. Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
Mol. Pharmacol., 2014 Oct , 86 (378-89).

126

Boehringer T et al. SCN5A mutations and polymorphisms in patients with ventricular fibrillation during acute myocardial infarction.
Mol Med Rep, 2014 Oct , 10 (2039-44).

127

Wang X et al. Angiotensin-(1-7) prevent atrial tachycardia induced sodium channel remodeling.
Pacing Clin Electrophysiol, 2014 Oct , 37 (1349-56).

128

Liu M et al. Cardiac sodium channel mutations: why so many phenotypes?
Nat Rev Cardiol, 2014 Oct , 11 (607-15).

129

Shy D et al. Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!
Circ. Res., 2014 Nov 7 , 115 (901-3).

130

Makara MA et al. Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
Circ. Res., 2014 Nov 7 , 115 (929-38).

131

Zhao Z et al. Cilostazol ameliorates atrial ionic remodeling in long-term rapid atrial pacing dogs.
Anatol J Cardiol, 2014 Nov 11 , ().

132

Gillet L et al. Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques.
Cardiovasc. Res., 2014 Nov 1 , 104 (231-3).

133

Chatin B et al. Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.
Biochem. J., 2014 Nov 1 , 463 (339-49).

134

Agullo-Pascual E et al. Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.
Cardiovasc. Res., 2014 Nov 1 , 104 (371-81).

135

Baskar S et al. Compound heterozygous mutations in the SCN5A-encoded Nav1.5 cardiac sodium channel resulting in atrial standstill and His-Purkinje system disease.
J. Pediatr., 2014 Nov , 165 (1050-2).

136

Beltran-Alvarez P et al. Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart.
J. Mol. Cell. Cardiol., 2014 Nov , 76 (126-9).

137

Xu L et al. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus.
Toxicon, 2014 Nov , 90 (318-25).

138

Ilkhanoff L et al. A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.
J. Cardiovasc. Electrophysiol., 2014 Nov , 25 (1150-7).

139

Frolov RV et al. Celecoxib and ion channels: a story of unexpected discoveries.
Eur. J. Pharmacol., 2014 May 5 , 730 (61-71).

140

Baptista-Hon DT et al. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function.
Br J Anaesth, 2014 May 22 , ().

141

Klint JK et al. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.
Biochem. Pharmacol., 2014 May 15 , 89 (276-86).

142

Wang GK et al. Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.
Mol. Pharmacol., 2014 May , 85 (692-702).

143

Zhao J et al. Relationship between two arrhythmias: sinus node dysfunction and atrial fibrillation.
Arch. Med. Res., 2014 May , 45 (351-5).

144

Wang Q et al. Gain-of-function KCNH2 mutations in patients with Brugada syndrome.
J. Cardiovasc. Electrophysiol., 2014 May , 25 (522-30).

145

Hartman ME et al. Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.
FASEB J., 2014 Mar 31 , ().

146

Zidar N et al. Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators.
Eur J Med Chem, 2014 Mar 3 , 74 (23-30).

147

Andreasen L et al. Brugada syndrome risk loci seem protective against atrial fibrillation.
Eur. J. Hum. Genet., 2014 Mar 26 , ().

148

Cerrone M et al. Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.
Circulation, 2014 Mar 11 , 129 (1092-103).

149

Gandjbakhch E et al. Malignant response to ajmaline challenge in SCN5A mutation carriers: experience from a large familial study.
Int. J. Cardiol., 2014 Mar 1 , 172 (256-8).

150

Chang RK et al. Genetic variants for long QT syndrome among infants and children from a statewide newborn hearing screening program cohort.
J. Pediatr., 2014 Mar , 164 (590-5.e1-3).

151

Liu C et al. Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder?
Forensic Sci. Int., 2014 Mar , 236 (38-45).

152

Elíes J et al. Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide.
J. Biol. Chem., 2014 Jun 6 , 289 (16421-9).

153

Yang T et al. Screening for Acute IKr Block is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current.
Circulation, 2014 Jun 3 , ().

154

Gao G et al. Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.
J. Am. Coll. Cardiol., 2014 Jun 3 , 63 (2261-9).

155

Boczek NJ et al. Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring Kv4.3 Protein Inhibitor and its Contribution to Brugada Syndrome.
Circ. Res., 2014 Jun 24 , ().

156

Coleman N et al. New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1.
Mol. Pharmacol., 2014 Jun 23 , ().

157

Ben-Johny M et al. Conservation of Ca(2+)/Calmodulin Regulation across Na and Ca(2+) Channels.
Cell, 2014 Jun 19 , 157 (1657-70).

158

Zhang Y et al. Measurement and interpretation of electrocardiographic QT intervals in murine hearts.
Am. J. Physiol. Heart Circ. Physiol., 2014 Jun 1 , 306 (H1553-7).

159

Aiba T et al. A mutation causing brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.
Circ Cardiovasc Genet, 2014 Jun , 7 (249-56).

160

Yin G et al. Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.
J Am Heart Assoc, 2014 Jun , 3 (e000996).

161

Abe K et al. Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics.
Circ Arrhythm Electrophysiol, 2014 Jun , 7 (511-7).

162

Xing D et al. Expression of neonatal Nav1.5 in human brain astrocytoma and its effect on proliferation, invasion and apoptosis of astrocytoma cells.
Oncol. Rep., 2014 Jun , 31 (2692-700).

163

Foadi N et al. Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid.
Anesth. Analg., 2014 Jun , 118 (1238-45).

164

Alday A et al. Ionic channels underlying the ventricular action potential in zebrafish embryo.
Pharmacol. Res., 2014 Jun , 84 (26-31).

165

Beyder A et al. Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome.
Gastroenterology, 2014 Jun , 146 (1659-68).

166

Ziyadeh-Isleem A et al. A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation.
Heart Rhythm, 2014 Jun , 11 (1015-23).

167

Magnani JW et al. Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Circ Cardiovasc Genet, 2014 Jun , 7 (365-73).

168

Hu D et al. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.
J. Am. Coll. Cardiol., 2014 Jul 8 , 64 (66-79).

169

Shy D et al. PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.
Circulation, 2014 Jul 8 , 130 (147-60).

170

Dybkova N et al. Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.
Cardiovasc. Res., 2014 Jul 1 , 103 (168-77).

171

Friedrich C et al. Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
EMBO Mol Med, 2014 Jul , 6 (937-51).

172

Glengarry JM et al. Long QT molecular autopsy in sudden infant death syndrome.
Arch. Dis. Child., 2014 Jul , 99 (635-40).

173

Savastano S et al. A comprehensive electrocardiographic, molecular, and echocardiographic study of Brugada syndrome: validation of the 2013 diagnostic criteria.
Heart Rhythm, 2014 Jul , 11 (1176-83).

174

Riuró H et al. A missense mutation in the sodium channel β1b subunit reveals SCN1B as a susceptibility gene underlying long QT syndrome.
Heart Rhythm, 2014 Jul , 11 (1202-9).

175

Martins RP et al. Dominant Frequency Increase Rate Predicts Transition from Paroxysmal to Long-Term Persistent Atrial Fibrillation.
Circulation, 2014 Jan 24 , ().

176

Lang F et al. Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.
Mol. Membr. Biol., 2014 Jan 14 , ().

177

Baroni D et al. Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression.
Biol. Cell, 2014 Jan , 106 (13-29).

178

Akylbekova EL et al. Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: the Jackson Heart Study.
Am. Heart J., 2014 Jan , 167 (116-122.e1).

179

Matsushita N et al. Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy.
Clin. Exp. Pharmacol. Physiol., 2014 Jan , 41 (89-97).

180

Gajewiak J et al. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.
Proc. Natl. Acad. Sci. U.S.A., 2014 Feb 18 , 111 (2758-63).

181

S P A second case with arrhythmogenic cardiomyopathy, provocable Brugada ECG and SCN5A mutation.
Int. J. Cardiol., 2014 Feb 15 , 171 (e117-8).

182

Hu D et al. ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.
Int. J. Cardiol., 2014 Feb 15 , 171 (431-42).

183

Hassink RJ et al. Fever-induced atrial flutter associated with SCN5A mutation--a first report on successful catheter ablation in a very young child.
Int. J. Cardiol., 2014 Feb 1 , 171 (e31-4).

184

Dulong C et al. The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.
Int. J. Oncol., 2014 Feb , 44 (539-47).

185

Jones JM et al. Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
Genesis, 2014 Feb , 52 (141-8).

186

Zhang Y et al. The SCN5A mutation A1180V is associated with electrocardiographic features of LQT3.
Pediatr Cardiol, 2014 Feb , 35 (295-300).

187

Jones A et al. Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense.
J. Biol. Chem., 2014 Dec 19 , 289 (35326-40).

188

Wei P et al. Jingzhaotoxin-35, a novel gating-modifier toxin targeting both Nav1.5 and Kv2.1 channels.
Toxicon, 2014 Dec 15 , 92 (90-6).

189

Schroder EA et al. Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice.
Am. J. Physiol. Heart Circ. Physiol., 2014 Dec 15 , 307 (H1777-85).

190

Tang C et al. The tarantula toxin jingzhaotoxin-XI (κ-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5.
Toxicon, 2014 Dec 15 , 92 (6-13).

191

Savio-Galimberti E et al. Atrial Fibrillation and SCN5A Variants.
Card Electrophysiol Clin, 2014 Dec 1 , 6 (741-748).

192

Swan H et al. Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias.
Circ Cardiovasc Genet, 2014 Dec , 7 (771-81).

193

Lodder EM et al. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.
Circ Cardiovasc Genet, 2014 Dec , 7 (790-8).

194

Huang WF et al. Role of sodium channels in the spontaneous excitability of early embryonic cardiomyocytes.
Chin J Physiol, 2014 Aug 31 , 57 (188-97).

195

Milano A et al. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy.
J. Am. Coll. Cardiol., 2014 Aug 26 , 64 (745-56).

196

Spencer CI et al. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.
Stem Cell Reports, 2014 Aug 12 , 3 (269-81).

197

Amin AS SCN5A-related dilated cardiomyopathy: what do we know?
Heart Rhythm, 2014 Aug , 11 (1454-5).

198

Imai M et al. Novel KCNQ1 splicing mutation in patients with forme fruste LQT1 aggravated by hypokalemia.
J Cardiol, 2014 Aug , 64 (121-6).

199

Zhang H et al. Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes.
Neurosci Bull, 2014 Aug , 30 (697-710).

200

Zhang Y et al. Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/- hearts.
Acta Physiol (Oxf), 2014 Aug , 211 (559-73).

201

Alexandrou AJ et al. The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.
J. Physiol. Pharmacol., 2014 Aug , 65 (511-23).

202

Beckermann TM et al. Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy.
Heart Rhythm, 2014 Aug , 11 (1446-53).

203

Pambrun T et al. Myotonic dystrophy type 1 mimics and exacerbates Brugada phenotype induced by Nav1.5 sodium channel loss-of-function mutation.
Heart Rhythm, 2014 Aug , 11 (1393-400).

204

Xiong Q et al. A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation.
Pharmacogenomics J., 2014 Aug , 14 (372-5).

205

Osorio N et al. Specialized functions of Nav1.5 and Nav1.9 channels in electrogenesis of myenteric neurons in intact mouse ganglia.
J. Neurosci., 2014 Apr 9 , 34 (5233-44).

206

Yuan L et al. Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant.
Am. J. Physiol. Heart Circ. Physiol., 2014 Apr 15 , 306 (H1204-12).

207

Abriel H et al. Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome.
Circ Cardiovasc Genet, 2014 Apr 1 , 7 (97-9).

208

van den Boogaard M et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression.
J. Clin. Invest., 2014 Apr 1 , 124 (1844-52).

209

Park DS et al. Nav-igating through a complex landscape: SCN10A and cardiac conduction.
J. Clin. Invest., 2014 Apr 1 , 124 (1460-2).

210

Hoshi M et al. Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations.
Circ Cardiovasc Genet, 2014 Apr 1 , 7 (123-31).

211

Wang D et al. Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths.
Forensic Sci. Int., 2014 Apr , 237 (90-9).

212

Kruse M et al. TRPM4 channels in the cardiovascular system.
Curr Opin Pharmacol, 2014 Apr , 15 (68-73).

213

Zhao Z et al. Protective effects of aliskiren on atrial ionic remodeling in a canine model of rapid atrial pacing.
Cardiovasc Drugs Ther, 2014 Apr , 28 (137-43).

214

Tester DJ et al. GENETICS OF LONG QT SYNDROME.
Methodist Debakey Cardiovasc J, 2014 1 , 10 (29-33).

215

Sumitomo N E1784K mutation in SCN5A and overlap syndrome.
Circ. J., 2014 , 78 (1839-40).

216

Nakaya H SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.
Circ. J., 2014 , 78 (1061-2).

217

Moreau A et al. Biophysics, pathophysiology, and pharmacology of ion channel gating pores.
Front Pharmacol, 2014 , 5 (53).

218

Inada S et al. Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing.
PLoS ONE, 2014 , 9 (e94565).

219

Meng E et al. Screening for voltage-gated sodium channel interacting peptides.
Sci Rep, 2014 , 4 (4569).

220

Rudokas MW et al. The Xenopus oocyte cut-open vaseline gap voltage-clamp technique with fluorometry.
J Vis Exp, 2014 , ().

221

Christiansen M et al. Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2.
BMC Med. Genet., 2014 , 15 (31).

222

Kanters JK et al. Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A.
Circ. J., 2014 , 78 (1136-43).

223

Saber S et al. [Clinical polymorphisms and approaches of arrhythmias treatment in a family with δKPQ1505-1507 deletion in SCN5A gene].
Vestn. Akad. Med. Nauk SSSR, 2014 , (52-9).

224

Juang JM et al. Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome.
Sci Rep, 2014 , 4 (6733).

225

Shimizu W Clinical and genetic diagnosis for inherited cardiac arrhythmias.
J Nippon Med Sch, 2014 , 81 (203-10).

226

Zakliaz'minskaia EV et al. [Dilated cardiomyopathy caused by p.E446K mutation in SCN5A gene].
Kardiologiia, 2014 , 54 (92-6).

227

Miller D et al. Sodium channels, cardiac arrhythmia, and therapeutic strategy.
Adv. Pharmacol., 2014 , 70 (367-92).

228

Yu CC et al. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
PLoS ONE, 2014 , 9 (e96691).

229

Jones DK et al. Proton modulation of cardiac I Na: a potential arrhythmogenic trigger.
Handb Exp Pharmacol, 2014 , 221 (169-81).

230

Antzelevitch C et al. The role of late I Na in development of cardiac arrhythmias.
Handb Exp Pharmacol, 2014 , 221 (137-68).

231

Vreeker A et al. Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart.
PLoS ONE, 2014 , 9 (e94722).

232

Li X et al. Isoprenaline: a potential contributor in sick sinus syndrome--insights from a mathematical model of the rabbit sinoatrial node.
ScientificWorldJournal, 2014 , 2014 (540496).

233

Fontes MS et al. Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy.
PLoS ONE, 2014 , 9 (e87226).

234

Juang JM et al. Utilizing multiple in silico analyses to identify putative causal SCN5A variants in Brugada syndrome.
Sci Rep, 2014 , 4 (3850).

235

Zimmer T et al. Voltage-gated sodium channels in the mammalian heart.
Glob Cardiol Sci Pract, 2014 , 2014 (449-63).

236

Takahashi K et al. High prevalence of the SCN5A E1784K mutation in school children with long QT syndrome living on the Okinawa islands.
Circ. J., 2014 , 78 (1974-9).

237

Jimmy JJ et al. Clinical characteristics of patients with congenital long QT syndrome and bigenic mutations.
Chin. Med. J., 2014 , 127 (1482-6).

238

Korogod SM et al. Dynamic excitation states and firing patterns are controlled by sodium channel kinetics in myenteric neurons: a simulation study.
Channels (Austin), 2014 , 8 (536-43).

239

Driffort V et al. Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization.
Mol. Cancer, 2014 , 13 (264).

240

Amarouch MY et al. Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies.
Channels (Austin), 2014 , 8 (414-20).

241

Uziębło-Życzkowska B et al. Genetic diversity of SCN5A gene and its possible association with the concealed form of Brugada syndrome development in Polish group of patients.
Biomed Res Int, 2014 , 2014 (462609).

242

Béziau DM et al. Complex Brugada syndrome inheritance in a family harbouring compound SCN5A and CACNA1C mutations.
Basic Res. Cardiol., 2014 , 109 (446).

243

Jiang S et al. H558R polymorphism in SCN5A is associated with Keshan disease and QRS prolongation in Keshan disease patients.
Genet. Mol. Res., 2014 , 13 (6569-76).

244

Ertugrul I et al. Follow up of a family with asymptomatic compound long QT syndrome mutations.
Genet. Couns., 2014 , 25 (399-403).

245

Gabelli SB et al. Regulation of the NaV1.5 cytoplasmic domain by calmodulin.
Nat Commun, 2014 , 5 (5126).

246

Tan ZP et al. Whole-exome sequencing identifies Y1495X of SCN5A to be associated with familial conduction disease and sudden death.
Sci Rep, 2014 , 4 (5616).

247

Ricci MT et al. SCN1B gene variants in Brugada Syndrome: a study of 145 SCN5A-negative patients.
Sci Rep, 2014 , 4 (6470).

248

Barajas-Martinez H et al. [Genetic and molecular basis for sodium channel-mediated Brugada syndrome].
Arch Cardiol Mex, 2013 Oct-Dec , 83 (295-302).

249

Partemi S et al. Analysis of the arrhythmogenic substrate in human heart failure.
Cardiovasc. Pathol., 2013 Mar-Apr , 22 (133-40).

250

Hermida JS et al. Dual phenotypic transmission in Brugada syndrome.
Arch Cardiovasc Dis, 2013 Jun-Jul , 106 (366-72).

251

Elkins RC et al. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.
J Pharmacol Toxicol Methods, 2013 Jul-Aug , 68 (112-22).

252

Morissette P et al. The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model.
J Pharmacol Toxicol Methods, 2013 Jul-Aug , 68 (137-49).

253

Qu Y et al. Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay.
J Pharmacol Toxicol Methods, 2013 Jul-Aug , 68 (74-81).

254

Wang GK et al. Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.
Channels (Austin), 2013 Jul-Aug , 7 (263-74).

255

Lang F et al. Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth.
Hormones (Athens), 2013 Apr-Jun , 12 (160-71).

256

Baczkó I et al. Characterization of a novel multi-functional resveratrol derivative for the treatment of atrial fibrillation.
Br. J. Pharmacol., 2013 Sep 18 , ().

257

Kodama T et al. Autosomal recessive paediatric sick sinus syndrome associated with novel compound mutations in SCN5A.
Int. J. Cardiol., 2013 Sep 10 , 167 (3078-80).

258

Washburn DG et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.
Bioorg. Med. Chem. Lett., 2013 Sep 1 , 23 (4979-84).

259

Shryock JC et al. The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.
Cardiovasc. Res., 2013 Sep 1 , 99 (600-11).

260

King JH et al. Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.
Cardiovasc. Res., 2013 Sep 1 , 99 (751-9).

261

Matthews GD et al. Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts.
J. Physiol. (Lond.), 2013 Sep 1 , 591 (4167-88).

262

Remme CA Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.
J. Physiol. (Lond.), 2013 Sep 1 , 591 (4099-116).

263

Zhu L et al. Two recombinant α-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na(+) channels.
Biochimie, 2013 Sep , 95 (1732-40).

264

Bezzina CR et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Nat. Genet., 2013 Sep , 45 (1044-9).

265

Zhang Q et al. Silencing of desmoplakin decreases connexin43/Nav1.5 expression and sodium current in HL‑1 cardiomyocytes.
Mol Med Rep, 2013 Sep , 8 (780-6).

266

Li N et al. A heterozygous missense SCN5A mutation associated with early repolarization syndrome.
Int. J. Mol. Med., 2013 Sep , 32 (661-7).

267

Sottas V et al. Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias.
J. Cardiovasc. Electrophysiol., 2013 Sep , 24 (1037-46).

268

Sommariva E et al. Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification.
Eur. J. Hum. Genet., 2013 Sep , 21 (911-7).

269

Tao H et al. Analysis of the Interaction of Tarantula Toxin Jingzhaotoxin-III (β-TRTX-Cj1α) with the Voltage Sensor of Kv2.1 Uncovers the Molecular Basis for Cross-Activities on Kv2.1 and Nav1.5 Channels.
Biochemistry, 2013 Oct 7 , ().

270

Olesen MS et al. Very early onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.
Heart Rhythm, 2013 Oct 18 , ().

271

Black JA et al. Noncanonical roles of voltage-gated sodium channels.
Neuron, 2013 Oct 16 , 80 (280-91).

272

Sheets MF et al. Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
Am. J. Physiol. Heart Circ. Physiol., 2013 Oct 15 , 305 (H1213-21).

273

Ma D et al. Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.
Int. J. Cardiol., 2013 Oct 15 , 168 (5277-86).

274

Hasegawa K et al. A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels.
Heart Rhythm, 2013 Oct 1 , ().

275

Chan YC et al. Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells.
J Cardiovasc Transl Res, 2013 Oct 1 , ().

276

Beltran-Alvarez P et al. Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel.
FEBS Lett., 2013 Oct 1 , 587 (3159-65).

277

Gao G et al. Unfolded protein response regulates cardiac sodium current in systolic human heart failure.
Circ Arrhythm Electrophysiol, 2013 Oct , 6 (1018-24).

278

Cuneo BF et al. Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: risk stratification of perinatal long-QT syndrome.
Circ Arrhythm Electrophysiol, 2013 Oct , 6 (946-51).

279

Lee YS et al. Long QT syndrome: a Korean single center study.
J. Korean Med. Sci., 2013 Oct , 28 (1454-60).

280

Eleawa SM et al. Effect of testosterone replacement therapy on cardiac performance and oxidative stress in orchidectomized rats.
Acta Physiol (Oxf), 2013 Oct , 209 (136-47).

281

Hummel YM et al. Ventricular dysfunction in a family with long QT syndrome type 3.
Europace, 2013 Oct , 15 (1516-21).

282

Marsman RF et al. Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
J. Am. Coll. Cardiol., 2013 Nov 18 , ().

283

Brisson L et al. NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia.
J. Cell. Sci., 2013 Nov 1 , 126 (4835-42).

284

Fedele F et al. Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease.
Basic Res. Cardiol., 2013 Nov , 108 (387).

285

Nadrowitz F et al. The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5.
Anesth. Analg., 2013 Nov , 117 (1101-8).

286

Westenbroek RE et al. Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.
J. Mol. Cell. Cardiol., 2013 Nov , 64 (69-78).

287

Risgaard B et al. High prevalence of genetic variants previously associated with Brugada syndrome in new exome data.
Clin. Genet., 2013 Nov , 84 (489-95).

288

Koenig X et al. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile.
Toxicol. Appl. Pharmacol., 2013 May 22 , ().

289

Lakatta EG et al. Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility".
Am. J. Physiol., Cell Physiol., 2013 May 15 , 304 (C941-4).

290

Watanabe H et al. SCN5A mutation associated with ventricular fibrillation, early repolarization, and concealed myocardial abnormalities.
Int. J. Cardiol., 2013 May 10 , 165 (e21-3).

291

Bardai A et al. Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community.
Eur. Heart J., 2013 May , 34 (1506-16).

292

An HS et al. Sudden cardiac arrest during anesthesia in a 30-month-old boy with syndactyly: a case of genetically proven Timothy syndrome.
J. Korean Med. Sci., 2013 May , 28 (788-91).

293

Aziz PF et al. Do LQTS gene single nucleotide polymorphisms alter QTc intervals at rest and during exercise stress testing?
Ann Noninvasive Electrocardiol, 2013 May , 18 (288-93).

294

Kim JJ et al. Bradycardia alters Ca(2+) dynamics enhancing dispersion of repolarization and arrhythmia risk.
Am. J. Physiol. Heart Circ. Physiol., 2013 Mar 15 , 304 (H848-60).

295

Shi RM et al. [Site-directed mutagenesis and protein expression of SCN5A gene associated with congenital long QT syndrome].
Zhongguo Dang Dai Er Ke Za Zhi, 2013 Mar , 15 (223-6).

296

Letsas KP et al. Sinus node disease in subjects with type 1 ECG pattern of Brugada syndrome.
J Cardiol, 2013 Mar , 61 (227-31).

297

Noorman M et al. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
Heart Rhythm, 2013 Mar , 10 (412-9).

298

Morris GM et al. Characterisation of a Right Atrial Subsidiary Pacemaker and acceleration of the pacing rate by HCN over-expression.
Cardiovasc. Res., 2013 Jun 19 , ().

299

Rahgozar K et al. Mediation of protection and recovery from experimental autoimmune encephalomyelitis by macrophages expressing the human voltage-gated sodium channel NaV1.5.
J. Neuropathol. Exp. Neurol., 2013 Jun , 72 (489-504).

300

Panguluri SK et al. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle.
Am. J. Physiol. Heart Circ. Physiol., 2013 Jun , 304 (H1651-61).

301

Lang F et al. Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.
Expert Opin Investig Drugs, 2013 Jun , 22 (701-14).

302

Revell JD et al. Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.
Peptides, 2013 Jun , 44 (40-6).

303

García-Molina E et al. A study of the SCN5A gene in a cohort of 76 patients with Brugada syndrome.
Clin. Genet., 2013 Jun , 83 (530-8).

304

Nilsson MF et al. Comparative effects of sodium channel blockers in short term rat whole embryo culture.
Toxicol. Appl. Pharmacol., 2013 Jul 8 , ().

305

Boukens BJ et al. Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.
Circ. Res., 2013 Jul 5 , 113 (137-41).

306

Korkmaz S et al. Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats.
J. Am. Coll. Cardiol., 2013 Jul 23 , 62 (340-9).

307

Jones DK et al. Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel.
Biophys. J., 2013 Jul 2 , 105 (101-7).

308

Ravens U et al. Atrial selectivity of antiarrhythmic drugs.
J. Physiol. (Lond.), 2013 Jul 16 , ().

309

McCormack K et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 16 , 110 (E2724-32).

310

Takanari H et al. Efficient and specific cardiac IK1 inhibition by a new pentamidine analogue.
Cardiovasc. Res., 2013 Jul 1 , 99 (203-14).

311

Son MK et al. Genetic mutation in korean patients of sudden cardiac arrest as a surrogating marker of idiopathic ventricular arrhythmia.
J. Korean Med. Sci., 2013 Jul , 28 (1021-6).

312

Gillet L et al. NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy.
Future Cardiol, 2013 Jul , 9 (467-70).

313

Li RG et al. Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation.
Int. J. Mol. Med., 2013 Jul , 32 (144-50).

314

Doki K et al. SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients.
Pharmacogenet. Genomics, 2013 Jul , 23 (349-54).

315

Lieve KV et al. Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.
Genet Test Mol Biomarkers, 2013 Jul , 17 (553-61).

316

Zhang Q et al. [Desmoplakin expression silencing affects cardiac voltage-gated sodium channel Nav1.5 in HL-1 cells].
Nan Fang Yi Ke Da Xue Xue Bao, 2013 Jul , 33 (983-9).

317

Schroder EA et al. The Cardiomyocyte Molecular Clock, Regulation of Scn5a and Arrhythmia Susceptibility.
Am. J. Physiol., Cell Physiol., 2013 Jan 30 , ().

318

Ford J et al. Human Electrophysiological and Pharmacological Properties of XEN-D0101: A Novel Atrial Selective Kv1.5/IKur Inhibitor.
J. Cardiovasc. Pharmacol., 2013 Jan 29 , ().

319

Wu AZ et al. Antiarrhythmic effects of (-)-epicatechin-3-gallate, a novel sodium channel agonist in cultured neonatal rat ventricular myocytes.
Biochem. Pharmacol., 2013 Jan 1 , 85 (69-80).

320

Boukens BJ et al. Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration.
Cardiovasc. Res., 2013 Jan 1 , 97 (182-91).

321

Terrenoire C et al. Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.
J. Gen. Physiol., 2013 Jan , 141 (61-72).

322

Lang F et al. Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.
FASEB J., 2013 Jan , 27 (3-12).

323

Liu L et al. A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome.
Heart Rhythm, 2013 Jan , 10 (61-7).

324

Gao G et al. RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.
Trends Cardiovasc. Med., 2013 Jan , 23 (5-8).

325

Andreasen C et al. Mutations in Genes Encoding Cardiac Ion Channels Previously Associated With Sudden Infant Death Syndrome (SIDS) Are Present With High Frequency in New Exome Data.
Can J Cardiol, 2013 Feb 25 , ().

326

Gao G et al. SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia.
Expert Rev Cardiovasc Ther, 2013 Feb , 11 (117-9).

327

Calloe K et al. Characterization and mechanisms of action of novel NaV1.5 channel mutations associated with Brugada syndrome.
Circ Arrhythm Electrophysiol, 2013 Feb , 6 (177-84).

328

Núñez L et al. p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient.
Heart Rhythm, 2013 Feb , 10 (264-72).

329

Yu J et al. SCN5A mutation in Chinese patients with arrhythmogenic right ventricular dysplasia.
Herz, 2013 Dec 8 , ().

330

van den Boogaard M et al. From GWAS to function: Genetic variation in sodium channel gene enhancer influences electrical patterning.
Trends Cardiovasc. Med., 2013 Dec 17 , ().

331

Hintsa T et al. Work stress and the long QT syndrome: high job strain and effort-reward imbalance at work associated with arrhythmic risk in the long QT syndrome.
J. Occup. Environ. Med., 2013 Dec , 55 (1387-93).

332

Wahbi K et al. Brugada syndrome and abnormal splicing of SCN5A in myotonic dystrophy type 1.
Arch Cardiovasc Dis, 2013 Dec , 106 (635-43).

333

Yu JH et al. [SCN5A mutation in patients with Brugada electrocardiographic pattern induced by fever].
Zhonghua Xin Xue Guan Bing Za Zhi, 2013 Dec , 41 (1010-4).

334

Kato K et al. Cardiac Channelopathies Associated with Infantile Fatal Ventricular Arrhythmias: From the Cradle to the Bench.
J. Cardiovasc. Electrophysiol., 2013 Aug 26 , ().

335

van Duijvenboden K et al. Gene regulatory elements of the cardiac conduction system.
Brief Funct Genomics, 2013 Aug 22 , ().

336

Bradley E et al. The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells.
Am. J. Physiol., Cell Physiol., 2013 Aug 15 , 305 (C427-35).

337

Herren AW et al. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias.
Am. J. Physiol. Heart Circ. Physiol., 2013 Aug 15 , 305 (H431-45).

338

Li A et al. Genetic biomarkers in Brugada syndrome.
Biomark Med, 2013 Aug , 7 (535-46).

339

Huttner IG et al. A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (123-32).

340

Parisi P et al. Coexistence of epilepsy and Brugada syndrome in a family with SCN5A mutation.
Epilepsy Res., 2013 Aug , 105 (415-8).

341

Li X et al. [A simulation study for the effect of acid concentration and temperture on sick sinus syndrome].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2013 Aug , 30 (697-703).

342

Bennett JS et al. Proliferation of embryonic cardiomyocytes in zebrafish requires the sodium channel scn5Lab.
Genesis, 2013 Aug , 51 (562-74).

343

Gao Y et al. A novel deletion-frameshift mutation in the S1 region of HERG gene in a Chinese family with long QT syndrome.
Chin. Med. J., 2013 Aug , 126 (3093-6).

344

Kaufmann SG et al. Distribution and function of sodium channel subtypes in human atrial myocardium.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (133-41).

345

Maury P et al. Novel SCN5A mutations in two families with "Brugada-like" ST elevation in the inferior leads and conduction disturbances.
J Interv Card Electrophysiol, 2013 Aug , 37 (131-40).

346

Toischer K et al. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (111-22).

347

Cheng J et al. Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A.
J. Mol. Cell. Cardiol., 2013 Aug , 61 (102-10).

348

Rhett JM et al. The perinexus: sign-post on the path to a new model of cardiac conduction?
Trends Cardiovasc. Med., 2013 Aug , 23 (222-8).

349

Mourão CB et al. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family.
Biochemistry, 2013 Apr 9 , 52 (2440-52).

350

Crotti L et al. Long QT syndrome-associated mutations in intrauterine fetal death.
JAMA, 2013 Apr 10 , 309 (1473-82).

351

Hu RM et al. Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome.
Am. J. Physiol. Heart Circ. Physiol., 2013 Apr 1 , 304 (H994-H1001).

352

Yoshikane Y et al. A case of long QT syndrome with triple gene abnormalities: digenic mutations in KCNH2 and SCN5A and gene variant in KCNE1.
Heart Rhythm, 2013 Apr , 10 (600-3).

353

Shy D et al. Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model.
Biochim. Biophys. Acta, 2013 Apr , 1833 (886-94).

354

Black JA et al. Nav1.5 sodium channels in macrophages in multiple sclerosis lesions.
Mult. Scler., 2013 Apr , 19 (532-42).

355

Shinwari ZM et al. Identification of a novel KCNQ1 mutation in a large Saudi family with long QT syndrome: clinical consequences and preventive implications.
Clin. Genet., 2013 Apr , 83 (370-4).

356

Kurakami K et al. Is a novel SCN3B mutation commonly found in SCN5A-negative Brugada syndrome patients?
Circ. J., 2013 , 77 (900-1).

357

King JH et al. Determinants of myocardial conduction velocity: implications for arrhythmogenesis.
Front Physiol, 2013 , 4 (154).

358

Kramer J et al. MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes.
Sci Rep, 2013 , 3 (2100).

359

Hegyi B et al. Selectivity problems with drugs acting on cardiac Na⁺ and Ca²⁺ channels.
Curr. Med. Chem., 2013 , 20 (2552-71).

360

Lübkemeier I et al. Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.
Basic Res. Cardiol., 2013 , 108 (348).

361

Zakliaz'minskaia EV et al. [Clinic and genetic polymorphism of Brugada syndrome in Russian patients, caused by mutation in SCN5A gene].
Khirurgiia (Mosk), 2013 , (49-53).

362

Tarradas A et al. A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome.
PLoS ONE, 2013 , 8 (e53220).

363

Di Domenico M et al. Biomarker discovery by plasma proteomics in familial Brugada Syndrome.
Front. Biosci., 2013 , 18 (564-71).

364

Jagu B et al. Identifying potential functional impact of mutations and polymorphisms: linking heart failure, increased risk of arrhythmias and sudden cardiac death.
Front Physiol, 2013 , 4 (254).

365

Reingardienė D et al. Brugada-like electrocardiographic patterns induced by hyperkalemia.
Medicina (Kaunas), 2013 , 49 (148-53).

366

Kaur K et al. TGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes.
PLoS ONE, 2013 , 8 (e55391).

367

Liu H et al. Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel.
PLoS ONE, 2013 , 8 (e54131).

368

Ishikawa T et al. Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5.
Circ. J., 2013 , 77 (959-67).

369

Atkinson AJ et al. Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart.
J Am Heart Assoc, 2013 , 2 (e000246).

370

Shimizu W Update of diagnosis and management of inherited cardiac arrhythmias.
Circ. J., 2013 , 77 (2867-72).

371

Zhang Z et al. Kinetic model of Nav1.5 channel provides a subtle insight into slow inactivation associated excitability in cardiac cells.
PLoS ONE, 2013 , 8 (e64286).

372

Shen C et al. A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese?
Dis. Markers, 2013 , 35 (531-5).

373

Zeng Z et al. Electrophysiological characteristics of a SCN5A voltage sensors mutation R1629Q associated with Brugada syndrome.
PLoS ONE, 2013 , 8 (e78382).

374

Dun W et al. Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart.
PLoS ONE, 2013 , 8 (e78087).

375

Auerbach DS et al. Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome.
PLoS ONE, 2013 , 8 (e77843).

376

Fujii M et al. New screening system for selective blockers of voltage-gated K(+) channels using recombinant cell lines dying upon single action potential.
J. Pharmacol. Sci., 2013 , 123 (147-58).

377

Zhou X et al. Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.
PLoS ONE, 2013 , 8 (e74390).

378

Nakajima S et al. A novel SCN5A mutation demonstrating a variety of clinical phenotypes in familial sick sinus syndrome.
Intern. Med., 2013 , 52 (1805-8).

379

Trolle C et al. Long QT interval in Turner syndrome--a high prevalence of LQTS gene mutations.
PLoS ONE, 2013 , 8 (e69614).

380

Zumhagen S et al. A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.
PLoS ONE, 2013 , 8 (e67963).

381

Fukuyama M et al. L-type calcium channel mutations in Japanese patients with inherited arrhythmias.
Circ. J., 2013 , 77 (1799-806).

382

Dolz-Gaitón P et al. Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family.
PLoS ONE, 2013 , 8 (e81493).

383

Uziębło-Życzkowska B et al. Congenital long QT syndrome of particularly malignant course connected with so far unknown mutation in the sodium channel SCN5A gene.
Cardiol J, 2013 , 20 (78-82).

384

Fatima A et al. The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients.
PLoS ONE, 2013 , 8 (e83005).

385

Jeevaratnam K et al. Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and sex.
Mech. Ageing Dev., 2012 Sep-Oct , 133 (591-9).

386

Strege P et al. Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells.
Channels (Austin), 2012 Nov-Dec , 6 (457-62).

387

Ildarova R et al. Sodium-channel blockers might contribute to the prevention of ventricular tachycardia in patients with long QT syndrome type 2: a description of 4 cases.
J Electrocardiol, 2012 May-Jun , 45 (237-43).

388

Holst AG et al. Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics.
Can J Cardiol, 2012 Mar-Apr , 28 (196-200).

389

Baruteau AE et al. Parental electrocardiographic screening identifies a high degree of inheritance for congenital and childhood nonimmune isolated atrioventricular block.
Circulation, 2012 Sep 18 , 126 (1469-77).

390

Chatelier A et al. A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts.
J. Physiol. (Lond.), 2012 Sep 1 , 590 (4307-19).

391

Zumhagen S et al. Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy.
Herzschrittmacherther Elektrophysiol, 2012 Sep , 23 (211-9).

392

Balasuriya D et al. The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.
J. Biol. Chem., 2012 Oct 26 , 287 (37021-9).

393

Mann SA et al. R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy.
J. Am. Coll. Cardiol., 2012 Oct 16 , 60 (1566-73).

394

Song W et al. The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.
J. Physiol. (Lond.), 2012 Oct 15 , 590 (5123-39).

395

Rougier JS et al. Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction.
Cardiovasc. Res., 2012 Oct 1 , 96 (1-3).

396

Clatot J et al. Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits.
Cardiovasc. Res., 2012 Oct 1 , 96 (53-63).

397

Zei PC et al. How insensitive … how a mutation in the SCN5A voltage sensor leads to clinical arrhythmia.
Heart Rhythm, 2012 Oct , 9 (1689-90).

398

Xi Y et al. Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction.
Circ Arrhythm Electrophysiol, 2012 Oct , 5 (1017-26).

399

Winkel BG et al. The prevalence of mutations in KCNQ1, KCNH2, and SCN5A in an unselected national cohort of young sudden unexplained death cases.
J. Cardiovasc. Electrophysiol., 2012 Oct , 23 (1092-8).

400

Nair K et al. Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.
Heart Rhythm, 2012 Oct , 9 (1681-1688.e1).

401

Carrasco JI et al. Flecainide, a therapeutic option in a patient with long QT syndrome type 3 caused by the heterozygous V411M mutation in the SCN5A gene.
Rev Esp Cardiol (Engl Ed), 2012 Nov , 65 (1058-9).

402

Matsusue A et al. An autopsy case of sudden unexpected nocturnal death syndrome with R1193Q polymorphism in the SCN5A gene.
Leg Med (Tokyo), 2012 Nov , 14 (317-9).

403

Duehmke RM et al. Altered re-excitation thresholds and conduction of extrasystolic action potentials contribute to arrhythmogenicity in murine models of long QT syndrome.
Acta Physiol (Oxf), 2012 Nov , 206 (164-77).

404

Hong K et al. Concomitant Brugada-like and short QT electrocardiogram linked to SCN5A mutation.
Eur. J. Hum. Genet., 2012 Nov , 20 (1189-92).

405

Abriel H Cardiac Sodium Channel Nav1.5 Mechanosensitivity is Inhibited by Ranolazine.
, 2012 May 7 , ().

406

Beyder A et al. Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel NaV1.5: A Novel Mechanism of Drug Action.
, 2012 May 7 , ().

407

Du YM et al. 18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.
, 2012 May 21 , ().

408

Santos LF et al. [Diagnostic criteria for the Brugada syndrome: can they be improved?].
Rev Port Cardiol, 2012 May , 31 (355-62).

409

Hu D et al. A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents.
Heart Rhythm, 2012 May , 9 (760-9).

410

Wacker SJ et al. Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2((3)) by High-Throughput Virtual Screening and Automated Patch Clamp.
, 2012 Mar 30 , ().

411

Hodgdon KE et al. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.
Neuroscience, 2012 Mar 29 , 206 (237-44).

412

O'Reilly JP et al. Time- and state-dependent effects of methanethiosulfonate ethylammonium (MTSEA) exposure differ between heart and skeletal muscle voltage-gated Na(+) channels.
Biochim. Biophys. Acta, 2012 Mar , 1818 (443-7).

413

Besana A et al. Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
J. Cardiovasc. Pharmacol., 2012 Mar , 59 (249-53).

414

Saucedo AL et al. Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 sodium channels.
Biochim. Biophys. Acta, 2012 Mar , 1824 (478-87).

415

Ashpole NM et al. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.
J. Biol. Chem., 2012 Jun 8 , 287 (19856-69).

416

Davis RP et al. Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease.
Circulation, 2012 Jun 26 , 125 (3079-91).

417

Hardziyenka M et al. Electrophysiologic remodeling of the left ventricle in pressure overload-induced right ventricular failure.
J. Am. Coll. Cardiol., 2012 Jun 12 , 59 (2193-202).

418

Catalano A et al. An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.
Drug Metab Lett, 2012 Jun 1 , 6 (124-8).

419

Gönczi M et al. Age-dependent changes in ion channel mRNA expression in canine cardiac tissues.
Gen. Physiol. Biophys., 2012 Jun , 31 (153-62).

420

Leffler A et al. Local anesthetic-like inhibition of voltage-gated Na(+) channels by the partial μ-opioid receptor agonist buprenorphine.
Anesthesiology, 2012 Jun , 116 (1335-46).

421

Tester DJ et al. Cardiac channel molecular autopsy: insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing.
Mayo Clin. Proc., 2012 Jun , 87 (524-39).

422

Ren CT et al. Cloning and expression of the two new variants of Nav1.5/SCN5A in rat brain.
Mol. Cell. Biochem., 2012 Jun , 365 (139-48).

423

Burashnikov A et al. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity.
J. Cardiovasc. Pharmacol., 2012 Jun , 59 (539-46).

424

Santos LF et al. Criteria to predict carriers of a novel SCN5A mutation in a large Portuguese family affected by the Brugada syndrome.
Europace, 2012 Jun , 14 (882-8).

425

Martin CA et al. Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice.
Open Biol, 2012 Jun , 2 (120072).

426

Guzadhur L et al. The age-dependence of atrial arrhythmogenicity in Scn5a+/- murine hearts reflects alterations in action potential propagation and recovery.
Clin. Exp. Pharmacol. Physiol., 2012 Jun , 39 (518-27).

427

Matthews GD et al. Nonlinearity between action potential alternans and restitution, which both predict ventricular arrhythmic properties in Scn5a+/- and wild-type murine hearts.
J. Appl. Physiol., 2012 Jun , 112 (1847-63).

428

Shimada T et al. A novel 5' splice site mutation of SCN5A associated with Brugada syndrome resulting in multiple cryptic transcripts.
Int. J. Cardiol., 2012 Jul 26 , 158 (441-3).

429

Yang T et al. Blocking scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Circ. Res., 2012 Jul 20 , 111 (322-32).

430

van den Boogaard M et al. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.
J. Clin. Invest., 2012 Jul 2 , 122 (2519-30).

431

Arnolds DE et al. TBX5 drives Scn5a expression to regulate cardiac conduction system function.
J. Clin. Invest., 2012 Jul 2 , 122 (2509-18).

432

Ritchie MD et al. Chromosome 4q25 Variants Are Genetic Modifiers of Rare Ion Channel Mutations Associated With Familial Atrial Fibrillation.
, 2012 Jul 10 , ().

433

Laurent G et al. Multifocal Ectopic Purkinje-Related Premature Contractions: A New SCN5A-Related Cardiac Channelopathy.
J. Am. Coll. Cardiol., 2012 Jul 10 , 60 (144-56).

434

Wei F et al. Mesenchymal stem cells neither fully acquire the electrophysiological properties of mature cardiomyocytes nor promote ventricular arrhythmias in infarcted rats.
Basic Res. Cardiol., 2012 Jul , 107 (274).

435

Yang M et al. Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.
Breast Cancer Res. Treat., 2012 Jul , 134 (603-15).

436

Lu J et al. Improving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapy.
J. Cardiovasc. Pharmacol., 2012 Jul , 60 (88-99).

437

Fujii M et al. Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates.
J Biomol Screen, 2012 Jul , 17 (773-84).

438

Park JK et al. Genetic variants in SCN5A promoter are associated with arrhythmia phenotype severity in patients with heterozygous loss-of-function mutation.
Heart Rhythm, 2012 Jul , 9 (1090-6).

439

Crotti L et al. Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant.
Heart Rhythm, 2012 Jul , 9 (1104-12).

440

Kanter RJ et al. Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.
Circulation, 2012 Jan 3 , 125 (14-22).

441

Poh YC et al. Quantification of gastrointestinal sodium channelopathy.
J. Theor. Biol., 2012 Jan 21 , 293 (41-8).

442

Fu LY et al. Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: A possible basis for modulation of excitability in vivo.
, 2012 Jan 1 , 6 ().

443

Rook MB et al. Biology of cardiac sodium channel Nav1.5 expression.
Cardiovasc. Res., 2012 Jan 1 , 93 (12-23).

444

Puppala D et al. Comparative gene expression profiling in human-induced pluripotent stem cell--derived cardiocytes and human and cynomolgus heart tissue.
Toxicol. Sci., 2012 Jan , 131 (292-301).

445

Catalano A et al. Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
J. Med. Chem., 2012 Feb 9 , 55 (1418-22).

446

Kauferstein S et al. Cardiac channelopathy causing sudden death as revealed by molecular autopsy.
, 2012 Feb 28 , ().

447

Luo HY et al. [Expression of Kir2.1, SCN5a and SCN1b channel genes in mouse cardiomyocytes with various electric properties: patch clamp combined with single cell RT-PCR study].
Sheng Li Xue Bao, 2012 Feb 25 , 64 (82-6).

448

Hallaq H et al. Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels.
Am. J. Physiol. Heart Circ. Physiol., 2012 Feb , 302 (H782-9).

449

Marionneau C et al. Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites.
J. Proteome Res., 2012 Dec 7 , 11 (5994-6007).

450

Gaunt TR et al. Integration of Genetics into a Systems Model of Electrocardiographic Traits Using HumanCVD BeadChip.
Circ Cardiovasc Genet, 2012 Dec 1 , 5 (630-8).

451

Ishikawa T et al. A Novel Disease Gene for Brugada Syndrome: Sarcolemmal Membrane-Associated Protein Gene Mutations Impair Intracellular Trafficking of hNav1.5.
Circ Arrhythm Electrophysiol, 2012 Dec 1 , 5 (1098-107).

452

Shiferaw K et al. One case, 3 rare simultaneous findings: intramyocardial bronchogenic cyst, P.H558R variant of SCN5A gene, and granular cell tumor of the esophagus.
Am J Forensic Med Pathol, 2012 Dec , 33 (335-8).

453

Chen L et al. Confirmation of a proarrhythmic risk underlying the clinical use of common Chinese herbal intravenous injections.
J Ethnopharmacol, 2012 Aug 1 , 142 (829-35).

454

Lowe JS et al. Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.
Cardiovasc. Res., 2012 Aug 1 , 95 (300-7).

455

Olesen MS et al. High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.
Circ Cardiovasc Genet, 2012 Aug 1 , 5 (450-9).

456

Selly JB et al. [Cardiac sinus node dysfunction due to a new mutation of the SCN5A gene].
Arch Pediatr, 2012 Aug , 19 (837-41).

457

Hegyi B et al. Tetrodotoxin blocks L-type Ca2+ channels in canine ventricular cardiomyocytes.
Pflugers Arch., 2012 Aug , 464 (167-74).

458

Sekiguchi K et al. Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5.
Clin Neurophysiol, 2012 Aug , 123 (1650-5).

459

Kwon HW et al. Long QT syndrome and dilated cardiomyopathy with SCN5A p.R1193Q polymorphism: cardioverter-defibrillator implantation at 27 months.
Pacing Clin Electrophysiol, 2012 Aug , 35 (e243-6).

460

Chinushi M et al. Exercise-related QT interval shortening with a peaked T wave in a healthy boy with a family history of sudden cardiac death.
Pacing Clin Electrophysiol, 2012 Aug , 35 (e239-42).

461

Song W et al. Cardiac sodium channel Nav1.5 mutations and cardiac arrhythmia.
Pediatr Cardiol, 2012 Aug , 33 (943-9).

462

Zamorano-León JJ et al. KCNH2 Gene Mutation: A Potential Link Between Epilepsy and Long QT-2 Syndrome.
, 2012 Apr 19 , ().

463

Wu J et al. Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.
Am. J. Physiol. Heart Circ. Physiol., 2012 Apr 1 , 302 (H1510-23).

464

Casado-Arroyo R et al. Letter by Casado-Arroyo et al regarding article, "Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization".
Circ Arrhythm Electrophysiol, 2012 Apr , 5 (e59; author reply e60-1).

465

Wang T et al. Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform.
Heart Rhythm, 2012 Apr , 9 (598-9).

466

Wang T et al. Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.
Am. J. Respir. Cell Mol. Biol., 2012 Apr , 46 (524-31).

467

Jansen JA et al. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
Heart Rhythm, 2012 Apr , 9 (600-7).

468

Murphy LL et al. Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia.
Heart Rhythm, 2012 Apr , 9 (590-7).

469

Lippi G et al. Genetic and clinical aspects of Brugada syndrome: an update.
Adv Clin Chem, 2012 , 56 (197-208).

470

Yang XF et al. The antibody targeting the e314 Peptide of human kv1.3 pore region serves as a novel, potent and specific channel blocker.
PLoS ONE, 2012 , 7 (e36379).

471

Mao W et al. Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1.
PLoS ONE, 2012 , 7 (e32738).

472

Veerakul G et al. Brugada syndrome: two decades of progress.
Circ. J., 2012 , 76 (2713-22).

473

van Hoorn F et al. SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility.
PLoS ONE, 2012 , 7 (e42037).

474

Gosselin-Badaroudine P et al. A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype.
PLoS ONE, 2012 , 7 (e38331).

475

Lazarczyk MJ et al. Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.
BMC Psychiatry, 2012 , 12 (220).

476

Nakajima T et al. KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram.
Circ. J., 2012 , 76 (2763-72).

477

O'Reilly AO et al. Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel.
PLoS ONE, 2012 , 7 (e41667).

478

Heath BM et al. Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.
J Pharmacol Toxicol Methods, 2011 May-Jun , 63 (258-68).

479

Patoine D et al. A novel KCNQ1 variant (L203P) associated with torsades de pointes-related syncope in a Steinert syndrome patient.
Can J Cardiol, 2011 Mar-Apr , 27 (263.e5-12).

480

Olesen MS et al. A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.
Can J Cardiol, 2011 Jul-Aug , 27 (523.e17-23).

481

Tanaka M et al. Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation.
Cardiovasc. Pathol., 2011 Jan-Feb , 20 (e37-42).

482

Gao G et al. Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.
Circulation, 2011 Sep 6 , 124 (1124-31).

483

Vohra J Diagnosis and Management of Brugada Syndrome.
, 2011 Sep 21 , ().

484

Kaczorowski GJ A molecular formula for heart failure and sudden cardiac death. Focus on "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice".
Am. J. Physiol., Cell Physiol., 2011 Sep , 301 (C557-8).

485

Rong M et al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5.
FASEB J., 2011 Sep , 25 (3177-85).

486

Yao L et al. Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
Am. J. Physiol., Cell Physiol., 2011 Sep , 301 (C577-86).

487

Eastaugh LJ et al. Brugada syndrome caused by a large deletion in SCN5A only detected by multiplex ligation-dependent probe amplification.
J. Cardiovasc. Electrophysiol., 2011 Sep , 22 (1073-6).

488

Cheng J et al. LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype.
Cardiogenetics, 2011 Oct 25 , 1 ().

489

Zhou Y et al. Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane.
, 2011 Oct 17 , ().

490

Lemoine MD et al. Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model.
Cardiovasc. Res., 2011 Oct 1 , 92 (67-74).

491

Calloe K et al. Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A.
Can. J. Physiol. Pharmacol., 2011 Oct , 89 (723-36).

492

Tester DJ et al. Unexplained drownings and the cardiac channelopathies: a molecular autopsy series.
Mayo Clin. Proc., 2011 Oct , 86 (941-7).

493

Zygmunt AC et al. Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block.
Am. J. Physiol. Heart Circ. Physiol., 2011 Oct , 301 (H1606-14).

494

Martin CA et al. Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a (+/-) mouse model.
Pflugers Arch., 2011 Oct , 462 (495-504).

495

Shinlapawittayatorn K et al. A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations.
Circ Cardiovasc Genet, 2011 Oct , 4 (500-9).

496

Kilinc OU et al. Successful Elimination of Significant Arrhythmia Burden with Flecainide in an Adolescent with Long QT Syndrome Type 3.
, 2011 Nov 30 , ().

497

Jones DK et al. Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5.
Biophys. J., 2011 Nov 2 , 101 (2147-56).

498

Chockalingam P et al. Loss-of-Function Sodium Channel Mutations in Infancy: A Pattern Unfolds.
, 2011 Nov 16 , ().

499

Parvez B et al. The "missing" link in atrial fibrillation heritability.
J Electrocardiol, 2011 Nov , 44 (641-4).

500

Byers MR et al. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels.
Arch. Oral Biol., 2011 Nov , 56 (1199-220).

501

McNair WP et al. SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism.
J. Am. Coll. Cardiol., 2011 May 24 , 57 (2160-8).

502

Cheng J et al. The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current.
Physiol. Genomics, 2011 May 13 , 43 (461-6).

503

Auerbach DS et al. Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers.
J. Physiol. (Lond.), 2011 May 1 , 589 (2363-81).

504

Martin CA et al. Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model.
Am. J. Physiol. Heart Circ. Physiol., 2011 May , 300 (H1853-62).

505

Horne AJ et al. A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation.
Heart Rhythm, 2011 May , 8 (770-7).

506

Postema PG et al. Sodium channelopathies: do we really understand what's going on?
J. Cardiovasc. Electrophysiol., 2011 May , 22 (590-3).

507

Zhang T et al. LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice.
Int. J. Cardiol., 2011 Mar 3 , 147 (239-45).

508

Novotny T et al. Mutation Analysis Ion Channel Genes Ventricular Fibrillation Survivors with Coronary Artery Disease.
, 2011 Mar 16 , ().

509

Strege PR et al. Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, NaV1.5.
, 2011 Mar 10 , ().

510

Olesen MS et al. Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation.
Cardiovasc. Res., 2011 Mar 1 , 89 (786-93).

511

Lopez KN et al. Homozygous mutation in SCN5A associated with atrial quiescence, recalcitrant arrhythmias, and poor capture thresholds.
Heart Rhythm, 2011 Mar , 8 (471-3).

512

Shinlapawittayatorn K et al. A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations.
Heart Rhythm, 2011 Mar , 8 (455-62).

513

Skinner JR et al. Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds.
Heart Rhythm, 2011 Mar , 8 (412-9).

514

Zhang JT et al. [Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels W822X].
Zhonghua Xin Xue Guan Bing Za Zhi, 2011 Mar , 39 (238-41).

515

Atack TC et al. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.
Circ. Res., 2011 Jun 24 , 109 (38-46).

516

Gurung IS et al. Deletion of the metabolic transcriptional coactivator PGC1{beta} induces cardiac arrhythmia.
, 2011 Jun 1 , ().

517

Kattygnarath D et al. MOG1: a new susceptibility gene for Brugada syndrome.
Circ Cardiovasc Genet, 2011 Jun , 4 (261-8).

518

Chi Y et al. [Synthesis, refolding and identification of pharmacological activities of neurotoxin JZTX-XI and R3A-JZTX-XI].
Sheng Wu Gong Cheng Xue Bao, 2011 Jun , 27 (900-8).

519

Beltran-Alvarez P et al. The cardiac sodium channel is post-translationally modified by arginine methylation.
, 2011 Jul 4 , ().

520

Bignolais O et al. Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block.
, 2011 Jul 22 , ().

521

Amin AS et al. Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome.
Europace, 2011 Jul , 13 (968-75).

522

Tveito A et al. Defining candidate drug characteristics for Long-QT (LQT3) syndrome.
Math Biosci Eng, 2011 Jul , 8 (861-73).

523

Barc J et al. Screening for copy number variation in genes associated with the long QT syndrome: clinical relevance.
J. Am. Coll. Cardiol., 2011 Jan 4 , 57 (40-7).

524

Abd Allah E et al. Changes in the expression of ion channels, connexins and Ca2+ handling proteins in the sinoatrial node during postnatal development.
, 2011 Jan 28 , ().

525

Bax NA et al. Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells.
, 2011 Jan 20 , ().

526

Firth AL et al. Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels.
Pulm Circ, 2011 Jan 1 , 1 (48-71).

527

Chockalingam P et al. Fever-induced life-threatening arrhythmias in children harboring an SCN5A mutation.
Pediatrics, 2011 Jan , 127 (e239-44).

528

Huang H et al. Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels.
Am. J. Physiol. Heart Circ. Physiol., 2011 Jan , 300 (H288-99).

529

Widmark J et al. Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes.
Mol. Biol. Evol., 2011 Jan , 28 (859-71).

530

Jeevaratnam K et al. Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex.
Pflugers Arch., 2011 Jan , 461 (29-44).

531

Hofshi A et al. A combined gene and cell therapy approach for restoration of conduction.
Heart Rhythm, 2011 Jan , 8 (121-30).

532

Bartos DC et al. R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation.
Heart Rhythm, 2011 Jan , 8 (48-55).

533

Moraes ER et al. Differential effects of Tityus bahiensis scorpion venom on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents.
Neurotox Res, 2011 Jan , 19 (102-14).

534

Ernesto C et al. [Investigation of ion channel gene variants in patients with long QT syndrome.]
, 2011 Feb 4 , ().

535

Petitprez S et al. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.
Circ. Res., 2011 Feb 4 , 108 (294-304).

536

Albesa M et al. Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice.
Cardiovasc. Res., 2011 Feb 1 , 89 (320-8).

537

Sun LP et al. [Update on cardiac SCN5A gene mutation and dilated cardiomyopathy].
Zhonghua Xin Xue Guan Bing Za Zhi, 2011 Feb , 39 (182-4).

538

Martin CA et al. Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model.
Am. J. Physiol. Heart Circ. Physiol., 2011 Feb , 300 (H605-16).

539

Yuan C et al. JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao.
, 2011 Dec 8 , ().

540

Davies MR et al. An In silico Canine Cardiac Midmyocardial Action Potential Duration Model as a Tool for Early Drug Safety Assessment.
, 2011 Dec 23 , ().

541

Watanabe H et al. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization.
Circ Arrhythm Electrophysiol, 2011 Dec , 4 (874-81).

542

Carrithers LM et al. The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations.
FEMS Immunol. Med. Microbiol., 2011 Dec , 63 (319-27).

543

Cheng J et al. Sudden unexplained nocturnal death syndrome in Southern China: an epidemiological survey and SCN5A gene screening.
Am J Forensic Med Pathol, 2011 Dec , 32 (359-63).

544

Baroni D et al. Molecular differential expression of voltage-gated sodium channel α and β subunit mRNAs in five different mammalian cell lines.
J. Bioenerg. Biomembr., 2011 Dec , 43 (729-38).

545

Sung RK et al. QTc prolongation and family history of sudden death in a patient with desmin cardiomyopathy.
Pacing Clin Electrophysiol, 2011 Dec , 34 (e105-8).

546

Doetzer AD et al. What can be done when asymptomatic patients discover they have Brugada syndrome? A case report of Brugada syndrome.
Int. J. Cardiol., 2011 Aug 4 , 150 (e96-7).

547

Watanabe H et al. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Circulation, 2011 Aug 30 , 124 (1001-11).

548

Möbius-Winkler S et al. New familial heterozygous c 4066_4068 delTT 2 bp deletion of the SCN5A gene causing Brugada syndrome.
Heart Rhythm, 2011 Aug , 8 (1224-7).

549

Ohno S et al. KCNE5 (KCNE1L) Variants Are Novel Modulator of Brugada Syndrome and Idiopathic Ventricular Fibrillation.
, 2011 Apr 14 , ().

550

Hao X et al. TGF-{beta}1 Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms Producing the Sinus Node Dysfunction Associated with SCN5A Deficiency and Aging.
, 2011 Apr 14 , ().

551

Sun AY et al. The S1103Y Cardiac Sodium Channel Variant Is Associated With Implantable Cardioverter-Defibrillator Events in Blacks With Heart Failure and Reduced Ejection Fraction.
Circ Cardiovasc Genet, 2011 Apr 1 , 4 (163-8).

552

Wilde AA et al. Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel.
Circ. Res., 2011 Apr 1 , 108 (884-97).

553

Jeff JM et al. SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study.
Circ Cardiovasc Genet, 2011 Apr , 4 (139-44).

554

Hekkala AM et al. Epinephrine bolus test in detecting long QT syndrome mutation carriers with indeterminable electrocardiographic phenotype.
Ann Noninvasive Electrocardiol, 2011 Apr , 16 (172-9).

555

Zhou R et al. Whole genome network analysis of ion channels and connexins in myocardial infarction.
Cell. Physiol. Biochem., 2011 , 27 (299-304).

556

Nakajima T et al. Identification of six novel SCN5A mutations in Japanese patients with Brugada syndrome.
Int Heart J, 2011 , 52 (27-31).

557

Winkel BG et al. Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis.
BMC Med. Genet., 2011 , 12 (22).

558

Smith JG et al. Genome-wide association studies of the PR interval in African Americans.
PLoS Genet., 2011 , 7 (e1001304).

559

Walzik S et al. Alternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels.
PLoS ONE, 2011 , 6 (e19188).

560

Frolov RV et al. Inhibition of HERG potassium channels by celecoxib and its mechanism.
PLoS ONE, 2011 , 6 (e26344).

561

Stein M et al. A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart.
PLoS ONE, 2011 , 6 (e20310).

562

Chen L et al. Polymorphism H558R in the human cardiac sodium channel SCN5A gene is associated with atrial fibrillation.
J. Int. Med. Res., 2011 , 39 (1908-16).

563

Himmel HM et al. QTc shortening with a new investigational cancer drug: a brief case study.
J Pharmacol Toxicol Methods, 2010 Jul-Aug , 62 (72-81).

564

House CD et al. Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.
Cancer Res., 2010 Sep 1 , 70 (6957-67).

565

Pignier C et al. Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.
Br. J. Pharmacol., 2010 Sep , 161 (79-91).

566

Jeevaratnam K et al. Differences in sino-atrial and atrio-ventricular function with age and sex attributable to the Scn5a+/- mutation in a murine cardiac model.
Acta Physiol (Oxf), 2010 Sep , 200 (23-33).

567

Bokil NJ et al. Molecular genetics of long QT syndrome.
Mol. Genet. Metab., 2010 Sep , 101 (1-8).

568

Tester DJ et al. Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing.
Am. J. Cardiol., 2010 Oct 15 , 106 (1124-8).

569

Kuryshev YA et al. Increased cardiac risk in concomitant methadone and diazepam treatment: pharmacodynamic interactions in cardiac ion channels.
J. Cardiovasc. Pharmacol., 2010 Oct , 56 (420-30).

570

van Stuijvenberg L et al. Alternative promoter usage and splicing of the human SCN5A gene contribute to transcript heterogeneity.
DNA Cell Biol., 2010 Oct , 29 (577-87).

571

Matthews GD et al. Regional variations in action potential alternans in isolated murine Scn5a(+/-) hearts during dynamic pacing.
Acta Physiol (Oxf), 2010 Oct , 200 (129-46).

572

Dautova Y et al. Atrial arrhythmogenic properties in wild-type and Scn5a+/- murine hearts.
Exp. Physiol., 2010 Oct , 95 (994-1007).

573

Murakami M et al. Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation.
J. Cardiovasc. Pharmacol., 2010 Oct , 56 (389-95).

574

Yamamura K et al. A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome.
Int. J. Cardiol., 2010 Nov 5 , 145 (61-4).

575

Kotta CM et al. Novel sodium channel SCN5A mutations in Brugada syndrome patients from Greece.
Int. J. Cardiol., 2010 Nov 5 , 145 (45-8).

576

Nishii N et al. SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome.
Circ. J., 2010 Nov 25 , 74 (2572-8).

577

Oka Y et al. Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome.
Circ. J., 2010 Nov 25 , 74 (2562-71).

578

Johannessen M et al. Antagonist Action of Progesterone at Sigma Receptors in the Modulation of Voltage-Gated Sodium Channels.
, 2010 Nov 17 , ().

579

Gavrielatos G et al. Sensitivity and specificity of sodium channel blocking test in the diagnosis of Brugada syndrome.
Int. J. Cardiol., 2010 May 28 , 141 (e31-3).

580

Sossalla S et al. Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium.
J. Am. Coll. Cardiol., 2010 May 25 , 55 (2330-42).

581

Kang J et al. In Vitro Electrocardiographic and Cardiac Ion Channel Effects of (-)-Epigallocatechin-3-Gallate, the Main Catechin of Green Tea.
, 2010 May 18 , ().

582

Gao R et al. Expression of voltage-gated sodium channel alpha subunit in human ovarian cancer.
Oncol. Rep., 2010 May , 23 (1293-9).

583

Allegue C et al. A new approach to long QT syndrome mutation detection by Sequenom MassARRAY system.
Electrophoresis, 2010 May , 31 (1648-55).

584

Gui J et al. Mutation-specific effects of polymorphism H558R in SCN5A-related sick sinus syndrome.
J. Cardiovasc. Electrophysiol., 2010 May , 21 (564-73).

585

Campuzano O et al. Genetics of Brugada syndrome.
Curr. Opin. Cardiol., 2010 May , 25 (210-5).

586

Lu JT et al. Recent progress in congenital long QT syndrome.
, 2010 Mar 10 , ().

587

Casini S et al. Tubulin polymerization modifies cardiac sodium channel expression and gating.
Cardiovasc. Res., 2010 Mar 1 , 85 (691-700).

588

Tu E et al. Post-mortem pathologic and genetic studies in "dead in bed syndrome" cases in type 1 diabetes mellitus.
Hum. Pathol., 2010 Mar , 41 (392-400).

589

Black JA et al. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.
Brain, 2010 Mar , 133 (835-46).

590

Amin AS et al. Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome.
Neth Heart J, 2010 Mar , 18 (165-9).

591

Hu D et al. Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome.
Pacing Clin Electrophysiol, 2010 Mar , 33 (274-85).

592

Lang F et al. Significance of SGK1 in the regulation of neuronal function.
, 2010 Jun 7 , ().

593

Gaborit N et al. Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
, 2010 Jun 21 , ().

594

Valdivia CR et al. Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Cardiovasc. Res., 2010 Jun 1 , 86 (392-400).

595

Tan BH et al. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.
Heart Rhythm, 2010 Jun , 7 (771-8).

596

Butters TD et al. Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.
Circ. Res., 2010 Jul 9 , 107 (126-37).

597

Wang P et al. Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population.
Biochem. Biophys. Res. Commun., 2010 Jul 16 , 398 (98-104).

598

Remme CA et al. Sodium Channel (Dys)Function and Cardiac Arrhythmias.
, 2010 Jul 14 , ().

599

Fabritz L et al. Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.
Cardiovasc. Res., 2010 Jul 1 , 87 (60-72).

600

Schroeter A et al. Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5.
J. Mol. Cell. Cardiol., 2010 Jul , 49 (16-24).

601

Desaphy JF et al. Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Br. J. Pharmacol., 2010 Jul , 160 (1521-33).

602

García-Castro M et al. The spectrum of SCN5A gene mutations in Spanish Brugada syndrome patients.
Rev Esp Cardiol, 2010 Jul , 63 (856-9).

603

Tester DJ et al. Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation.
Heart Rhythm, 2010 Jul , 7 (912-9).

604

Liu JF et al. Mutation-specific risk in two genetic forms of type 3 long QT syndrome.
Am. J. Cardiol., 2010 Jan 15 , 105 (210-3).

605

Skinner JR et al. The SCN5A gene in Brugada syndrome: mutations, variants, missense and nonsense. What's a clinician to do?
Heart Rhythm, 2010 Jan , 7 (50-1).

606

Adabag AS et al. Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation.
Am. Heart J., 2010 Jan , 159 (33-9).

607

Hakim P et al. Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties.
Acta Physiol (Oxf), 2010 Jan , 198 (47-59).

608

Jarecki BW et al. Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.
J. Clin. Invest., 2010 Jan , 120 (369-78).

609

Abriel H Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology.
J. Mol. Cell. Cardiol., 2010 Jan , 48 (2-11).

610

Tfelt-Hansen J et al. Inherited cardiac diseases caused by mutations in the Nav1.5 sodium channel.
J. Cardiovasc. Electrophysiol., 2010 Jan , 21 (107-15).

611

Kapplinger JD et al. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing.
Heart Rhythm, 2010 Jan , 7 (33-46).

612

Saba S et al. Effect of right ventricular versus biventricular pacing on electrical remodeling in the normal heart.
Circ Arrhythm Electrophysiol, 2010 Feb 1 , 3 (79-87).

613

Xu L et al. [The cardiac sodium channel gene SCN5A mutation and dilated cardiomyopathy].
Sheng Li Ke Xue Jin Zhan, 2010 Feb , 41 (72-4).

614

Pfeufer A et al. Genome-wide association study of PR interval.
Nat. Genet., 2010 Feb , 42 (153-9).

615

Ogawa R et al. A novel microsatellite polymorphism of sodium channel beta1-subunit gene (SCN1B) may underlie abnormal cardiac excitation manifested by coved-type ST-elevation compatible with Brugada syndrome in Japanese.
Int J Clin Pharmacol Ther, 2010 Feb , 48 (109-19).

616

Nakajima T et al. Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.
J. Mol. Cell. Cardiol., 2010 Feb , 48 (352-9).

617

Chioni AM et al. Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Int. J. Biochem. Cell Biol., 2010 Feb , 42 (346-58).

618

Stirnimann G et al. Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine.
Europace, 2010 Feb , 12 (282-3).

619

Fukaya H et al. Combined effects of up- and downstream therapies on atrial fibrillation in a canine rapid stimulation model.
, 2010 Dec 28 , ().

620

Chagot B et al. Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5.
, 2010 Dec 15 , ().

621

Hermida JS et al. Prospective evaluation of the familial prevalence of the brugada syndrome.
Am. J. Cardiol., 2010 Dec 15 , 106 (1758-62).

622

Beyder A et al. Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel.
J. Physiol. (Lond.), 2010 Dec 15 , 588 (4969-85).

623

Amin AS et al. SCN5A mutations in atrial fibrillation.
Heart Rhythm, 2010 Dec , 7 (1870-1).

624

Oh S et al. Remodeling of ion channel expression in patients with chronic atrial fibrillation and mitral valvular heart disease.
Korean J. Intern. Med., 2010 Dec , 25 (377-85).

625

Cao X et al. Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.
Assay Drug Dev Technol, 2010 Dec , 8 (766-80).

626

Cheng J et al. SCN5A rare variants in familial dilated cardiomyopathy decrease peak sodium current depending on the common polymorphism H558R and common splice variant Q1077del.
Clin Transl Sci, 2010 Dec , 3 (287-94).

627

Blana A et al. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
Heart Rhythm, 2010 Dec , 7 (1862-9).

628

Zhang T et al. LQTS gene LOVD database.
, 2010 Aug 31 , ().

629

Tu E et al. Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases.
, 2010 Aug 24 , ().

630

Neu A et al. A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease.
Hum. Mutat., 2010 Aug , 31 (E1609-21).

631

Guzadhur L et al. Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.
Pflugers Arch., 2010 Aug , 460 (593-601).

632

Cheng HW et al. Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine.
Neurosci Bull, 2010 Aug , 26 (289-96).

633

Chopra SS et al. Voltage-gated sodium channels are required for heart development in zebrafish.
Circ. Res., 2010 Apr 30 , 106 (1342-50).

634

Ruan Y et al. Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.
Circ. Res., 2010 Apr 30 , 106 (1374-83).

635

Albert CM et al. Common Variants in Cardiac Ion Channel Genes Are Associated with Sudden Cardiac Death.
, 2010 Apr 17 , ().

636

Lee HA et al. Electrophysiological Effects of the Anti-Cancer Drug Lapatinib on Cardiac Repolarization.
, 2010 Apr 12 , ().

637

Martini B To the editor--the compendium of SCN5A mutations.
Heart Rhythm, 2010 Apr , 7 (e1).

638

Subbiah RN et al. Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates.
Can J Cardiol, 2010 Apr , 26 (208-12).

639

Nof E et al. A common single nucleotide polymorphism can exacerbate long-QT type 2 syndrome leading to sudden infant death.
Circ Cardiovasc Genet, 2010 Apr , 3 (199-206).

640

Toh N et al. Atrial electrophysiological and structural remodeling in high-risk patients with Brugada syndrome: assessment with electrophysiology and echocardiography.
Heart Rhythm, 2010 , 7 (218-24).

641

Hoogendijk MG et al. Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.
Heart Rhythm, 2010 , 7 (238-48).

642

Holst AG et al. Sick sinus syndrome, progressive cardiac conduction disease, atrial flutter and ventricular tachycardia caused by a novel SCN5A mutation.
Cardiology, 2010 , 115 (311-6).

643

Gui J et al. Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome.
PLoS ONE, 2010 , 5 (e10985).

644

Léoni AL et al. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
PLoS ONE, 2010 , 5 (e9298).

645

Kotta CM et al. Cardiac ion channel gene mutations in Greek long QT syndrome patients.
J. Appl. Genet., 2010 , 51 (515-8).

646

Berecki G et al. Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions.
PLoS ONE, 2010 , 5 (e15772).

647

Cao Z et al. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits.
BMC Neurosci, 2010 , 11 (154).

648

Baines AJ et al. Protein 4.1 and the control of ion channels.
Blood Cells Mol. Dis., 2009 May-Jun , 42 (211-5).

649

Lee HA et al. Cellular mechanism of the QT prolongation induced by sulpiride.
Int. J. Toxicol., 2009 May-Jun , 28 (207-12).

650

Papp F et al. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.
Toxicon, 2009 Sep 15 , 54 (379-89).

651

Samani K et al. A nonsense SCN5A mutation associated with Brugada-type electrocardiogram and intraventricular conduction defects.
Pacing Clin Electrophysiol, 2009 Sep , 32 (1231-6).

652

Remme CA et al. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium.
Basic Res. Cardiol., 2009 Sep , 104 (511-22).

653

Kapplinger JD et al. Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.
Heart Rhythm, 2009 Sep , 6 (1297-303).

654

Samani K et al. A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness.
Heart Rhythm, 2009 Sep , 6 (1318-26).

655

Liu M et al. Cardiac Na+ current regulation by pyridine nucleotides.
Circ. Res., 2009 Oct 9 , 105 (737-45).

656

Heron SE et al. Neonatal seizures and Long QT Syndrome: A cardiocerebral channelopathy?
Epilepsia, 2009 Oct 27 , ().

657

Lizotte E et al. Genetic modulation of brugada syndrome by a common polymorphism.
J. Cardiovasc. Electrophysiol., 2009 Oct , 20 (1137-41).

658

Valdivia CR et al. GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A.
Am. J. Physiol. Heart Circ. Physiol., 2009 Oct , 297 (H1446-52).

659

Silver ES et al. Long QT syndrome due to a novel mutation in SCN5A: treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age.
J Interv Card Electrophysiol, 2009 Oct , 26 (41-5).

660

Amin AS et al. Exercise-induced ECG changes in Brugada syndrome.
Circ Arrhythm Electrophysiol, 2009 Oct , 2 (531-9).

661

Kapa S et al. Genetic testing for long-QT syndrome: distinguishing pathogenic mutations from benign variants.
Circulation, 2009 Nov 3 , 120 (1752-60).

662

Amin AS et al. Cardiac sodium channelopathies.
, 2009 Nov 29 , ().

663

Soltysinska E et al. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts.
Pflugers Arch., 2009 Nov , 459 (11-23).

664

Nakatome M et al. Diplotype analysis of the human cardiac sodium channel regulatory region in Japanese cases of sudden death by unknown causes.
Leg Med (Tokyo), 2009 Nov , 11 (298-301).

665

Maguy A et al. Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure.
Circ. Res., 2009 May 8 , 104 (1113-22).

666

Nishio H et al. Identification of an ethnic-specific variant (V207M) of the KCNQ1 cardiac potassium channel gene in sudden unexplained death and implications from a knock-in mouse model.
Int. J. Legal Med., 2009 May , 123 (253-7).

667

Makita N Phenotypic overlap of cardiac sodium channelopathies: individual-specific or mutation-specific?
Circ. J., 2009 May , 73 (810-7).

668

Maltsev VA et al. Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.
J Physiol Sci, 2009 May , 59 (217-25).

669

Ruan Y et al. Sodium channel mutations and arrhythmias.
Nat Rev Cardiol, 2009 May , 6 (337-48).

670

Okazaki R et al. lipopolysaccharide induces atrial arrhythmogenesis via down-regulation of L-type Ca2+ channel genes in rats.
, 2009 May , 50 (353-63).

671

Smith JG et al. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
Heart Rhythm, 2009 May , 6 (634-41).

672

Chagot B et al. Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5.
J. Biol. Chem., 2009 Mar 6 , 284 (6436-45).

673

Miloushev VZ et al. Solution structure of the NaV1.2 C-terminal EF-hand domain.
J. Biol. Chem., 2009 Mar 6 , 284 (6446-54).

674

Huang H et al. Biophysical characterization of a new SCN5A mutation S1333Y in a SIDS infant linked to long QT syndrome.
FEBS Lett., 2009 Mar 4 , 583 (890-6).

675

van Opstal JM et al. Provocation of silence.
, 2009 Mar , 11 (385-7).

676

Aurlien D et al. New SCN5A mutation in a SUDEP victim with idiopathic epilepsy.
, 2009 Mar , 18 (158-60).

677

Kawamura M et al. Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up.
Circ. J., 2009 Mar , 73 (584-8).

678

Meregalli PG et al. Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies.
, 2009 Mar , 6 (341-8).

679

Tfelt-Hansen J et al. Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A.
, 2009 Mar , 25 (156-60).

680

Remme CA et al. Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.
Circ. Res., 2009 Jun 5 , 104 (1283-92).

681

Hedley PL et al. The genetic basis of Brugada syndrome: A mutation update.
Hum. Mutat., 2009 Jun 16 , ().

682

Lacunza J et al. Heat stroke, an unusual trigger of Brugada electrocardiogram.
, 2009 Jun , 27 (634.e1-3).

683

Bush WS et al. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.
Pharmacogenomics, 2009 Jun , 10 (1043-53).

684

Hu D et al. A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype.
Circ Cardiovasc Genet, 2009 Jun , 2 (270-8).

685

Watanabe H et al. Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.
Circ Arrhythm Electrophysiol, 2009 Jun , 2 (268-75).

686

Stein M et al. Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction.
Cardiovasc. Res., 2009 Jul 1 , 83 (52-60).

687

Frustaci A et al. Structural myocardial abnormalities in asymptomatic family members with Brugada syndrome and SCN5A gene mutation.
Eur. Heart J., 2009 Jul , 30 (1763).

688

Turillazzi E et al. Immunohistochemical marker for Na+ CP type Valpha (C-20) and heterozygous nonsense SCN5A mutation W822X in a sudden cardiac death induced by mild anaphylactic reaction.
Appl. Immunohistochem. Mol. Morphol., 2009 Jul , 17 (357-62).

689

Wu SN et al. The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells.
Neurotoxicology, 2009 Jul , 30 (677-85).

690

Carlsson L et al. Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo.
J. Cardiovasc. Pharmacol., 2009 Jul , 54 (82-9).

691

Dautova Y et al. Atrial arrhythmogenesis in wild-type and Scn5a+/delta murine hearts modelling LQT3 syndrome.
Pflugers Arch., 2009 Jul , 458 (443-57).

692

Lau DH et al. Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.
Circulation, 2009 Jan 6 , 119 (19-27).

693

Johnson JN et al. Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy.
Neurology, 2009 Jan 20 , 72 (224-31).

694

Farre C et al. Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology.
Comb. Chem. High Throughput Screen., 2009 Jan , 12 (24-37).

695

Lehtinen AB et al. Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study.
Ann Noninvasive Electrocardiol, 2009 Jan , 14 (72-9).

696

Li Q et al. Gain-of-function mutation of Nav1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing.
Biochem. Biophys. Res. Commun., 2009 Feb 27 , 380 (132-7).

697

Protas L et al. Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.
Cardiovasc. Res., 2009 Feb 15 , 81 (528-35).

698

Gaborit N et al. Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases.
Eur. Heart J., 2009 Feb , 30 (487-96).

699

Saito YA et al. Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy.
Am. J. Physiol. Gastrointest. Liver Physiol., 2009 Feb , 296 (G211-8).

700

Bai R et al. Yield of genetic screening in inherited cardiac channelopathies: how to prioritize access to genetic testing.
Circ Arrhythm Electrophysiol, 2009 Feb , 2 (6-15).

701

Husser D et al. A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation.
Circ Arrhythm Electrophysiol, 2009 Feb , 2 (24-8).

702

Gao R et al. Functional expression of voltage-gated sodium channels Nav1.5 in human breast cancer cell line MDA-MB-231.
J. Huazhong Univ. Sci. Technol. Med. Sci., 2009 Feb , 29 (64-7).

703

Onkal R et al. Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer.
Eur. J. Pharmacol., 2009 Dec 25 , 625 (206-19).

704

Cheng J et al. Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current.
Circ Arrhythm Electrophysiol, 2009 Dec , 2 (667-76).

705

Escárcega RO et al. The Brugada syndrome.
Acta Cardiol, 2009 Dec , 64 (795-801).

706

Shi RM et al. [Gene mutation analysis of a Chinese family of congenital long Q-T syndrome type three.]
Zhonghua Er Ke Za Zhi, 2009 Dec , 47 (926-30).

707

Probst V et al. SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome.
Circ Cardiovasc Genet, 2009 Dec , 2 (552-7).

708

Iturralde-Torres P et al. [Genetic in long QT syndromes]
Arch Cardiol Mex, 2009 Dec , 79 Suppl 2 (26-30).

709

Black JA et al. Sodium channel activity modulates multiple functions in microglia.
Glia, 2009 Aug 1 , 57 (1072-81).

710

Teng S et al. Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels.
Cardiovasc. Res., 2009 Aug 1 , 83 (473-80).

711

Crotti L et al. Novel human pathological mutations. Gene symbol: SCN5A. Disease: Brugada Syndrome.
Hum. Genet., 2009 Aug , 126 (339).

712

Benson DW Compound heterozygous SCN5A mutations: does the sum of the parts equal the whole?
Heart Rhythm, 2009 Aug , 6 (1176-7).

713

Lindegger N et al. Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.
J. Mol. Cell. Cardiol., 2009 Aug , 47 (326-34).

714

Wang J et al. Analysis of four novel variants of Nav1.5/SCN5A cloned from the brain.
Neurosci. Res., 2009 Aug , 64 (339-47).

715

Sangawa M et al. Abnormal transmural repolarization process in patients with Brugada syndrome.
Heart Rhythm, 2009 Aug , 6 (1163-9).

716

Medeiros-Domingo A et al. Unique mixed phenotype and unexpected functional effect revealed by novel compound heterozygosity mutations involving SCN5A.
Heart Rhythm, 2009 Aug , 6 (1170-5).

717

Xi Y et al. Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model.
Eur. J. Heart Fail., 2009 Aug , 11 (749-57).

718

Tfelt-Hansen J et al. [Inherited cardiac diseases caused by Nav1.5 sodium channel mutations]
Ugeskr. Laeg., 2009 Apr 6 , 171 (1261-5).

719

Millat G et al. Rapid, sensitive and inexpensive detection of SCN5A genetic variations by high resolution melting analysis.
Clin. Biochem., 2009 Apr , 42 (491-9).

720

Desaphy JF et al. Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine.
Pain, 2009 Apr , 142 (225-35).

721

Morita H et al. Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome.
, 2009 Apr , 6 (487-92).

722

Oliva A et al. SCN5A mutation associated with acute myocardial infarction.
Leg Med (Tokyo), 2009 Apr , 11 Suppl 1 (S206-9).

723

Pfeufer A et al. Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nat. Genet., 2009 Apr , 41 (407-14).

724

Newton-Cheh C et al. Common variants at ten loci influence QT interval duration in the QTGEN Study.
Nat. Genet., 2009 Apr , 41 (399-406).

725

Hsueh CH et al. Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutations.
J. Biomed. Sci., 2009 , 16 (23).

726

Thakor DK et al. Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.
, 2009 , 5 (14).

727

Wang L et al. Ionic mechanisms underlying action potential prolongation by focal cerebral ischemia in rat ventricular myocytes.
Cell. Physiol. Biochem., 2009 , 23 (305-16).

728

Kinoshita-Kikuta E et al. Zn(II)-cyclen polyacrylamide gel electrophoresis for SNP detection.
Methods Mol. Biol., 2009 , 578 (169-82).

729

Chiang KC et al. Characterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome.
J. Biomed. Sci., 2009 , 16 (76).

730

Lei M et al. Genetic Na+ channelopathies and sinus node dysfunction.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (171-8).

731

Zimmer T et al. SCN5A channelopathies--an update on mutations and mechanisms.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (120-36).

732

Charpentier F et al. Mouse models of SCN5A-related cardiac arrhythmias.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (230-7).

733

Hakim P et al. Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (251-66).

734

Hothi SS et al. Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome.
Prog. Biophys. Mol. Biol., 2008 Oct-Nov , 98 (267-80).

735

Wang J et al. New variants of Nav1.5/SCN5A encode Na+ channels in the brain.
J. Neurogenet., 2008 Jan-Mar , 22 (57-75).

736

Harmer AR et al. Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks.
, 2008 Jan-Feb , 57 (30-41).

737

Christé G et al. Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3.
Prog. Biophys. Mol. Biol., 2008 Jan-Apr , 96 (281-93).

738

Kinoshita E et al. Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.
Anal. Biochem., 2008 Sep 1 , 380 (122-7).

739

Onkal R et al. Alternative splicing of Nav1.5: an electrophysiological comparison of 'neonatal' and 'adult' isoforms and critical involvement of a lysine residue.
J. Cell. Physiol., 2008 Sep , 216 (716-26).

740

Feng XH et al. Electrophysiological characterization of BmK I, an alpha-like scorpion toxin, on rNav1.5 expressed in HEK293t cells.
Toxicol In Vitro, 2008 Sep , 22 (1582-7).

741

Bierhuizen MF et al. In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
J. Mol. Cell. Cardiol., 2008 Sep , 45 (373-84).

742

Eddy CA et al. Identification of large gene deletions and duplications in KCNQ1 and KCNH2 in patients with long QT syndrome.
Heart Rhythm, 2008 Sep , 5 (1275-81).

743

Xiao Y et al. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
J. Biol. Chem., 2008 Oct 3 , 283 (27300-13).

744

Hong L et al. Letter by Hong et al regarding article, "Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation".
Circulation, 2008 Oct 14 , 118 (e668; author reply e669).

745

Makiyama T et al. A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation.
J. Am. Coll. Cardiol., 2008 Oct 14 , 52 (1326-34).

746

Stagg MA et al. Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart.
Circ. Res., 2008 Oct 10 , 103 (855-63).

747

Benito B et al. A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation.
Heart Rhythm, 2008 Oct , 5 (1434-40).

748

Nyholt DR et al. A high-density association screen of 155 ion transport genes for involvement with common migraine.
Hum. Mol. Genet., 2008 Nov 1 , 17 (3318-31).

749

Lindegger N et al. Look beyond the hERG mutation: a neutral SCN5A variant may turn lidocaine into a threat.
Heart Rhythm, 2008 Nov , 5 (1575-6).

750

Remme CA et al. SCN5A overlap syndromes: no end to disease complexity?
Europace, 2008 Nov , 10 (1253-5).

751

Otagiri T et al. Cardiac ion channel gene mutations in sudden infant death syndrome.
Pediatr. Res., 2008 Nov , 64 (482-7).

752

Lin MT et al. In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant.
Heart Rhythm, 2008 Nov , 5 (1567-74).

753

Shi R et al. The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction disorder, dilated cardiomyopathy, and high incidence of youth sudden death.
Europace, 2008 Nov , 10 (1329-35).

754

Yuan BB et al. [Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome]
Zhonghua Xin Xue Guan Bing Za Zhi, 2008 May , 36 (404-7).

755

Van Norstrand DW et al. Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome.
Heart Rhythm, 2008 May , 5 (712-5).

756

Johnson JN et al. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome.
Heart Rhythm, 2008 May , 5 (704-9).

757

Hershberger RE et al. Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy.
Clin Transl Sci, 2008 May , 1 (21-6).

758

Holland KD et al. Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy.
Neurosci. Lett., 2008 Mar 5 , 433 (65-70).

759

Kusano KF et al. Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds.
J. Am. Coll. Cardiol., 2008 Mar 25 , 51 (1169-75).

760

Wu L et al. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5.
J. Biol. Chem., 2008 Mar 14 , 283 (6968-78).

761

Surber R et al. Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel.
Cardiovasc. Res., 2008 Mar 1 , 77 (740-8).

762

Yang P et al. Polymorphisms in the cardiac sodium channel promoter displaying variant in vitro expression activity.
Eur. J. Hum. Genet., 2008 Mar , 16 (350-7).

763

Wang GK et al. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.
Mol. Pharmacol., 2008 Mar , 73 (940-8).

764

Saint DA The cardiac persistent sodium current: an appealing therapeutic target?
Br. J. Pharmacol., 2008 Mar , 153 (1133-42).

765

Doolan A et al. Postmortem molecular analysis of KCNQ1 and SCN5A genes in sudden unexplained death in young Australians.
Int. J. Cardiol., 2008 Jun 23 , 127 (138-41).

766

Mazzone A et al. A mutation in telethonin alters Nav1.5 function.
J. Biol. Chem., 2008 Jun 13 , 283 (16537-44).

767

Petitprez S et al. Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome.
Cardiovasc. Res., 2008 Jun 1 , 78 (494-504).

768

Ge J et al. Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy.
Circ Arrhythm Electrophysiol, 2008 Jun 1 , 1 (83-92).

769

Crotti L et al. Gene symbol: SCN5A. Disease: Brugada syndrome.
Hum. Genet., 2008 Jun , 123 (542).

770

Crotti L et al. Gene symbol: SCN5A. Disease: Brugada syndrome.
Hum. Genet., 2008 Jun , 123 (542).

771

Makita N et al. The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.
J. Clin. Invest., 2008 Jun , 118 (2219-29).

772

Watanabe H et al. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans.
J. Clin. Invest., 2008 Jun , 118 (2260-8).

773

Makita N et al. Absence of a trafficking defect in R1232W/T1620M, a double SCN5A mutant responsible for Brugada syndrome.
Circ. J., 2008 Jun , 72 (1018-9).

774

Ueda K et al. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Proc. Natl. Acad. Sci. U.S.A., 2008 Jul 8 , 105 (9355-60).

775

Peters S Arrhythmogenic right ventricular dysplasia-cardiomyopathy and provocable coved-type ST-segment elevation in right precordial leads: clues from long-term follow-up.
, 2008 Jul , 10 (816-20).

776

Erkapic D et al. Electrical storm in a patient with arrhythmogenic right ventricular cardiomyopathy and SCN5A mutation.
, 2008 Jul , 10 (884-7).

777

Bébarová M et al. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation.
Am. J. Physiol. Heart Circ. Physiol., 2008 Jul , 295 (H48-58).

778

Albert CM et al. Cardiac sodium channel gene variants and sudden cardiac death in women.
Circulation, 2008 Jan 1 , 117 (16-23).

779

Sabir IN et al. Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome.
Pflugers Arch., 2008 Jan , 455 (637-51).

780

Shang LL et al. NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II.
Am. J. Physiol., Cell Physiol., 2008 Jan , 294 (C372-9).

781

Ellinor PT et al. Cardiac sodium channel mutation in atrial fibrillation.
, 2008 Jan , 5 (99-105).

782

Six I et al. The occurrence of Brugada syndrome and isolated cardiac conductive disease in the same family could be due to a single SCN5A mutation or to the accidental association of both diseases.
, 2008 Jan , 10 (79-85).

783

Nguyen TP et al. Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia.
Circ. Res., 2008 Feb 15 , 102 (364-71).

784

Kort ME et al. Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J. Med. Chem., 2008 Feb 14 , 51 (407-16).

785

Wu L et al. Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.
Cardiovasc. Res., 2008 Feb 1 , 77 (481-8).

786

Sun A et al. SCN5A R1193Q polymorphism associated with progressive cardiac conduction defects and long QT syndrome in a Chinese family.
J. Med. Genet., 2008 Feb , 45 (127-8).

787

Wada A et al. Voltage-dependent Na(v)1.7 sodium channels: multiple roles in adrenal chromaffin cells and peripheral nervous system.
Acta Physiol (Oxf), 2008 Feb , 192 (221-31).

788

Fukaya H et al. Inhomogenic effect of bepridil on atrial electrical remodeling in a canine rapid atrial stimulation model.
Circ. J., 2008 Feb , 72 (318-26).

789

Takemasa H et al. Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.
Br. J. Pharmacol., 2008 Feb , 153 (439-47).

790

Zhang Y et al. Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel.
Acta Physiol (Oxf), 2008 Dec , 194 (311-23).

791

Shimizu W Clinical impact of genetic studies in lethal inherited cardiac arrhythmias.
Circ. J., 2008 Dec , 72 (1926-36).

792

Wang DW et al. Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.
Circ Arrhythm Electrophysiol, 2008 Dec , 1 (370-8).

793

Moss AJ et al. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome.
J. Cardiovasc. Electrophysiol., 2008 Dec , 19 (1289-93).

794

Barajas-Martínez HM et al. Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.
Circ. Res., 2008 Aug 15 , 103 (396-404).

795

Turillazzi E et al. Heterozygous nonsense SCN5A mutation W822X explains a simultaneous sudden infant death syndrome.
Virchows Arch., 2008 Aug , 453 (209-16).

796

Maltsev VA et al. Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.
Am. J. Physiol. Heart Circ. Physiol., 2008 Aug , 295 (H667-76).

797

Olszak-Waśkiewicz M et al. The association between SCN5A, KCNQ1 and KCNE1 gene polymorphisms and complex ventricular arrhythmias in survivors of myocardial infarction.
, 2008 Aug , 66 (845-53; discussion 854-5).

798

Koskela J et al. Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.
Transl Res, 2008 Aug , 152 (49-58).

799

Darbar D et al. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.
Circulation, 2008 Apr 15 , 117 (1927-35).

800

Domínguez JN et al. Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development.
Cardiovasc. Res., 2008 Apr 1 , 78 (45-52).

801

Thomas G et al. Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndrome.
Acta Physiol (Oxf), 2008 Apr , 192 (505-17).

802

Fang DH et al. Association of human SCN5A polymorphisms with idiopathic ventricular arrhythmia in a Chinese Han cohort.
Circ. J., 2008 Apr , 72 (592-7).

803

Shan L et al. SCN5A variants in Japanese patients with left ventricular noncompaction and arrhythmia.
Mol. Genet. Metab., 2008 Apr , 93 (468-74).

804

Zhang Y et al. Single nucleotide polymorphisms and haplotype of four genes encoding cardiac ion channels in Chinese and their association with arrhythmia.
Ann Noninvasive Electrocardiol, 2008 Apr , 13 (180-90).

805

Remme CA et al. Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations.
Trends Cardiovasc. Med., 2008 Apr , 18 (78-87).

806

Oliva A et al. Clinical heterogeneity in sodium channelopathies. What is the meaning of carrying a genetic mutation?
Cardiology, 2008 , 110 (116-22).

807

Raudenská M et al. Mutation analysis of candidate genes SCN1B, KCND3 and ANK2 in patients with clinical diagnosis of long QT syndrome.
Physiol Res, 2008 , 57 (857-62).

808

Crotti L et al. Congenital long QT syndrome.
, 2008 , 3 (18).

809

Berge KE et al. Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers.
Scand. J. Clin. Lab. Invest., 2008 , 68 (362-8).

810

Drago A et al. Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia.
Curr. Med. Chem., 2008 , 15 (2472-517).

811

Márquez MF et al. A novel SCN5A deletion mutation in a child with ventricular tachycardia, recurrent aborted sudden death, and Brugada electrocardiographic pattern.
, 2007 Oct-Dec , 77 (284-7).

812

Hu D et al. Genetic predisposition and cellular basis for ischemia-induced ST-segment changes and arrhythmias.
, 2007 Nov-Dec , 40 (S26-9).

813

Zhu ZI et al. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram.
, 2007 Nov-Dec , 40 (S47-50).

814

Denjoy I et al. [Brugada syndrome]
, 2007 Jul-Aug , 36 (1109-16).

815

Bankston JR et al. A novel LQT-3 mutation disrupts an inactivation gate complex with distinct rate-dependent phenotypic consequences.
Channels (Austin), 2007 Jul-Aug , 1 (273-80).

816

Ruan Y et al. Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients.
Circulation, 2007 Sep 4 , 116 (1137-44).

817

Zhang Y et al. A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death.
Eur. J. Pediatr., 2007 Sep , 166 (927-33).

818

Gouas L et al. Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects.
Eur. J. Hum. Genet., 2007 Sep , 15 (974-9).

819

Aizawa Y et al. A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome.
J. Cardiovasc. Electrophysiol., 2007 Sep , 18 (972-7).

820

Abriel H Cardiac sodium channel Nav1.5 and its associated proteins.
Arch Mal Coeur Vaiss, 2007 Sep , 100 (787-93).

821

Etheridge SP et al. Long QT syndrome in children in the era of implantable defibrillators.
J. Am. Coll. Cardiol., 2007 Oct 2 , 50 (1335-40).

822

Clancy CE et al. Mutation-specific effects of lidocaine in Brugada syndrome.
Int. J. Cardiol., 2007 Oct 18 , 121 (249-52).

823

Itoh H et al. A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome.
Int. J. Cardiol., 2007 Oct 18 , 121 (239-48).

824

Chung SK et al. Long QT and Brugada syndrome gene mutations in New Zealand.
, 2007 Oct , 4 (1306-14).

825

Shang LL et al. Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel.
Circ. Res., 2007 Nov 26 , 101 (1146-54).

826

London B et al. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias.
Circulation, 2007 Nov 13 , 116 (2260-8).

827

Seda M et al. Functional and molecular characterization of voltage-gated sodium channels in uteri from nonpregnant rats.
Biol. Reprod., 2007 Nov , 77 (855-63).

828

Pignier C et al. Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity.
Basic Res. Cardiol., 2007 Nov , 102 (553-64).

829

Lezoualc'h F et al. Quantitative mRNA analysis of serotonin 5-HT4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation.
Biochem. Biophys. Res. Commun., 2007 May 25 , 357 (218-24).

830

Stokoe KS et al. Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome.
J. Physiol. (Lond.), 2007 May 15 , 581 (255-75).

831

Wang SY et al. Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel.
Pflugers Arch., 2007 May , 454 (277-87).

832

Vanmolkot KR et al. The novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Mutation in brief #957. Online.
Hum. Mutat., 2007 May , 28 (522).

833

Skinner JR et al. Brugada syndrome masquerading as febrile seizures.
Pediatrics, 2007 May , 119 (e1206-11).

834

Wu L et al. Induction of high STAT1 expression in transgenic mice with LQTS and heart failure.
Biochem. Biophys. Res. Commun., 2007 Jun 29 , 358 (449-54).

835

Carrithers MD et al. Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification.
J. Immunol., 2007 Jun 15 , 178 (7822-32).

836

Lei M et al. SCN5A and sinoatrial node pacemaker function.
Cardiovasc. Res., 2007 Jun 1 , 74 (356-65).

837

Du Y et al. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat.
Pflugers Arch., 2007 Jun , 454 (451-9).

838

Kerr NC et al. The sodium channel Nav1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Nav1.5 channel.
Mol. Cell. Neurosci., 2007 Jun , 35 (283-91).

839

Frigo G et al. Homozygous SCN5A mutation in Brugada syndrome with monomorphic ventricular tachycardia and structural heart abnormalities.
, 2007 Jun , 9 (391-7).

840

de Boer TP et al. Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.
Circ. J., 2007 Jun , 71 (973-81).

841

Koo SH et al. Mutation screening in KCNQ1, HERG, KCNE1, KCNE2 and SCN5A genes in a long QT syndrome family.
Ann. Acad. Med. Singap., 2007 Jun , 36 (394-8).

842

Kiehne N et al. Mutations in the SCN5A gene: evidence for a link between long QT syndrome and sudden death?
Forensic Sci Int Genet, 2007 Jun , 1 (170-4).

843

Flaim SN et al. Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation.
Heart Rhythm, 2007 Jun , 4 (768-78).

844

Koopmann TT et al. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort.
Heart Rhythm, 2007 Jun , 4 (752-5).

845

Gaborit N et al. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart.
J. Physiol. (Lond.), 2007 Jul 15 , 582 (675-93).

846

Medeiros-Domingo A et al. SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.
Circulation, 2007 Jul 10 , 116 (134-42).

847

Liao Z et al. Solution structure of Jingzhaotoxin-III, a peptide toxin inhibiting both Nav1.5 and Kv2.1 channels.
Toxicon, 2007 Jul , 50 (135-43).

848

Ouyang W et al. Isoform-selective effects of isoflurane on voltage-gated Na+ channels.
Anesthesiology, 2007 Jul , 107 (91-8).

849

Shin DJ et al. A novel mutation in the SCN5A gene is associated with Brugada syndrome.
Life Sci., 2007 Jan 30 , 80 (716-24).

850

Tian XL et al. Optical mapping of ventricular arrhythmias in LQTS mice with SCN5A mutation N1325S.
Biochem. Biophys. Res. Commun., 2007 Jan 26 , 352 (879-83).

851

Wang DW et al. Cardiac sodium channel dysfunction in sudden infant death syndrome.
Circulation, 2007 Jan 23 , 115 (368-76).

852

Arnestad M et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome.
Circulation, 2007 Jan 23 , 115 (361-7).

853

Yong SL et al. Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes.
Biochem. Biophys. Res. Commun., 2007 Jan 12 , 352 (378-83).

854

Stokoe KS et al. Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3.
J. Physiol. (Lond.), 2007 Jan 1 , 578 (69-84).

855

Thomas G et al. Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.
J. Physiol. (Lond.), 2007 Jan 1 , 578 (85-97).

856

Brackenbury WJ et al. The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells.
Breast Cancer Res. Treat., 2007 Jan , 101 (149-60).

857

Vecchietti S et al. In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes.
Am. J. Physiol. Heart Circ. Physiol., 2007 Jan , 292 (H56-65).

858

Nakano Y et al. Non-SCN5A related Brugada syndromes: verification of normal splicing and trafficking of SCN5A without exonic mutations.
Ann. Hum. Genet., 2007 Jan , 71 (8-17).

859

Huang X et al. [Expression and function of voltage-gated Na+ channel isoforms in rat sinoatrial node]
Nan Fang Yi Ke Da Xue Xue Bao, 2007 Jan , 27 (52-5).

860

Pfahnl AE et al. A sodium channel pore mutation causing Brugada syndrome.
Heart Rhythm, 2007 Jan , 4 (46-53).

861

Chen LY et al. A common polymorphism in SCN5A is associated with lone atrial fibrillation.
Clin. Pharmacol. Ther., 2007 Jan , 81 (35-41).

862

Kinoshita E et al. A single nucleotide polymorphism genotyping method using phosphate-affinity polyacrylamide gel electrophoresis.
Anal. Biochem., 2007 Feb 15 , 361 (294-8).

863

Harrell MD et al. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Physiol. Genomics, 2007 Feb 12 , 28 (273-83).

864

Crotti L et al. Gene symbol: SCN5A.
Hum. Genet., 2007 Feb , 120 (911-2).

865

Crotti L et al. Gene symbol: SCN5A.
Hum. Genet., 2007 Feb , 120 (913).

866

Priest BT et al. ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.
Toxicon, 2007 Feb , 49 (194-201).

867

Strege PR et al. Species dependent expression of intestinal smooth muscle mechanosensitive sodium channels.
Neurogastroenterol. Motil., 2007 Feb , 19 (135-43).

868

Chevalier P et al. Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition.
, 2007 Feb , 4 (170-4).

869

Cronk LB et al. Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3.
Heart Rhythm, 2007 Feb , 4 (161-6).

870

Williams BS et al. Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.
Biochemistry, 2007 Dec 18 , 46 (14693-703).

871

Abriel H Roles and regulation of the cardiac sodium channel Na v 1.5: recent insights from experimental studies.
Cardiovasc. Res., 2007 Dec 1 , 76 (381-9).

872

Casini S et al. Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation.
Cardiovasc. Res., 2007 Dec 1 , 76 (418-29).

873

Tan BH et al. A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia.
Cardiovasc. Res., 2007 Dec 1 , 76 (409-17).

874

Chancey JH et al. Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.
Am. J. Physiol., Cell Physiol., 2007 Dec , 293 (C1895-905).

875

Zaragoza MV et al. Noncompaction of the left ventricle: primary cardiomyopathy with an elusive genetic etiology.
Curr. Opin. Pediatr., 2007 Dec , 19 (619-27).

876

Gongadze N et al. Prolong QT interval and "torsades de pointes" associated with different group of drugs.
Georgian Med News, 2007 Dec , (45-9).

877

Tian L et al. [Gene (SCN5A) mutation analysis of a Chinese family with Brugada syndrome]
Zhonghua Xin Xue Guan Bing Za Zhi, 2007 Dec , 35 (1122-5).

878

Yokokawa M et al. Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5A-positive probands and the SCN5A-negative probands.
Am. J. Cardiol., 2007 Aug 15 , 100 (649-55).

879

Morris CE et al. Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch.
Biophys. J., 2007 Aug 1 , 93 (822-33).

880

Hesse M et al. Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a.
Cardiovasc. Res., 2007 Aug 1 , 75 (498-509).

881

Hu D et al. Novel mutation in the SCN5A gene associated with arrhythmic storm development during acute myocardial infarction.
, 2007 Aug , 4 (1072-80).

882

Zhang T et al. Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.
Biochem. Biophys. Res. Commun., 2007 Apr 6 , 355 (444-50).

883

Shuraih M et al. A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.
J. Cardiovasc. Electrophysiol., 2007 Apr , 18 (434-40).

884

Makita N et al. Novel SCN5A mutation (Q55X) associated with age-dependent expression of Brugada syndrome presenting as neurally mediated syncope.
, 2007 Apr , 4 (516-9).

885

Bokeria LA et al. [The clinical variability of and approaches to treatment of life-threatening ventricular arrhythmias caused by SCN5A gene mutations]
Vestn. Akad. Med. Nauk SSSR, 2007 , (3-11).

886

Chopra SS et al. Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates.
BMC Evol. Biol., 2007 , 7 (113).

887

Alonso-Atienza F et al. Action potential alternans in LQT3 syndrome: a simulation study.
, 2007 , 2007 (640-3).

888

Bankston JR et al. A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response.
PLoS ONE, 2007 , 2 (e1258).

889

Herbert E et al. Clinical aspects and physiopathology of Brugada syndrome: review of current concepts.
Can. J. Physiol. Pharmacol., 2006 Aug-Sep , 84 (795-802).

890

Johnson D et al. Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.
J. Biol. Chem., 2006 Sep 8 , 281 (25875-81).

891

Brette F et al. Density and sub-cellular distribution of cardiac and neuronal sodium channel isoforms in rat ventricular myocytes.
Biochem. Biophys. Res. Commun., 2006 Sep 29 , 348 (1163-6).

892

Mathie A et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.
Pharmacol. Ther., 2006 Sep , 111 (567-83).

893

Millat G et al. Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.
Clin. Genet., 2006