Channelpedia

Aydar E et al. Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Eur. Biophys. J., 2016 May 9 , ().

Yang J et al. FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner.
Channels (Austin), 2016 May 31 , (1-11).

Hirano-Iwata A et al. Reconstitution of Human Ion Channels into Solvent-free Lipid Bilayers Enhanced by Centrifugal Forces.
Biophys. J., 2016 May 24 , 110 (2207-15).

Zeng H et al. Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.
J Pharmacol Toxicol Methods, 2016 May 21 , ().

Schilling JM et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice.
Basic Res. Cardiol., 2016 May , 111 (28).

Daumy X et al. Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I.
Int. J. Cardiol., 2016 Mar 15 , 207 (349-58).

Tao H et al. Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels.
Toxicon, 2016 Mar 1 , 111 (13-21).

Zhao Y et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.
Int. J. Mol. Med., 2016 Jun , 37 (1511-20).

Zaklyazminskaya E et al. The role of mutations in the SCN5A gene in cardiomyopathies.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1799-805).

Sottas V et al. Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.
Biochim. Biophys. Acta, 2016 Jul , 1863 (1791-8).

Van Driest SL et al. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
JAMA, 2016 Jan 5 , 315 (47-57).

Wang HG et al. A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.
J. Mol. Cell. Cardiol., 2016 Jan 19 , 92 (52-62).

Mohammed FH et al. Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells.
Int. J. Oncol., 2016 Jan , 48 (73-83).

Neubauer J et al. Post-mortem whole-exome sequencing (WES) with a focus on cardiac disease-associated genes in five young sudden unexplained death (SUD) cases.
Int. J. Legal Med., 2016 Feb 4 , ().

Poulet C et al. Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillation.
Physiol Rep, 2016 Feb , 4 ().

Crumb WJ et al. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
J Pharmacol Toxicol Methods, 2016 Apr 6 , ().

Shcherbatko A et al. Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain.
J. Biol. Chem., 2016 Apr 22 , ().

Nassal DM et al. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role.
PLoS ONE, 2016 , 11 (e0146561).

Zhao Y et al. Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells.
BMC Cardiovasc Disord, 2016 , 16 (1).

Portero V et al. Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome.
J Am Heart Assoc, 2016 , 5 ().

Kubanek J et al. Ultrasound modulates ion channel currents.
Sci Rep, 2016 , 6 (24170).

Choi JI et al. α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.
PLoS ONE, 2016 , 11 (e0152355).

Leo-Macias A et al. Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.
Nat Commun, 2016 , 7 (10342).

Hertz CL et al. Genetic investigations of sudden unexpected deaths in infancy using next-generation sequencing of 100 genes associated with cardiac diseases.
Eur. J. Hum. Genet., 2015 Sep 9 , ().

Eberhardt E et al. Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors.
Stem Cell Reports, 2015 Sep 8 , 5 (305-13).

Climent AM et al. The Role of Atrial Tissue Remodeling on Rotor Dynamics: An In-Vitro Study.
Am. J. Physiol. Heart Circ. Physiol., 2015 Sep 25 , (ajpheart.00055.2015).

Neshatian L et al. Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.
Am. J. Physiol. Gastrointest. Liver Physiol., 2015 Sep 15 , 309 (G506-12).

Abdelsayed M et al. Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants.
J. Physiol. (Lond.), 2015 Sep 15 , 593 (4201-23).

Berghuis B et al. Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy.
Epilepsy Res., 2015 Sep , 115 (141-4).

Aktas CC et al. In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.
Acta Biochim. Biophys. Sin. (Shanghai), 2015 Sep , 47 (680-6).

Farrugia A et al. Targeted next generation sequencing application in cardiac channelopathies: Analysis of a cohort of autopsy-negative sudden unexplained deaths.
Forensic Sci. Int., 2015 Sep , 254 (5-11).

Musa H et al. SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Proc. Natl. Acad. Sci. U.S.A., 2015 Oct 6 , 112 (12528-33).

Nunn LM et al. Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing.
Europace, 2015 Oct 25 , ().

Endo R et al. Carvedilol Suppresses Apoptosis and Ion Channel Remodelling of HL-1 Cardiac Myocytes Expressing E334K cMyBPC.
Drug Res (Stuttg), 2015 Oct 19 , ().

Beyder A et al. Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.
Neurogastroenterol. Motil., 2015 Oct 13 , ().

Detta N et al. The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.
Biochim. Biophys. Acta, 2015 Oct , 1854 (1502-9).

Chiang DY et al. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture.
Circ Arrhythm Electrophysiol, 2015 Oct , 8 (1105-12).

Murray JK et al. Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
Bioorg. Med. Chem. Lett., 2015 Nov 1 , 25 (4866-71).

Han Z et al. The effects of A-803467 on cardiac Nav1.5 channels.
Eur. J. Pharmacol., 2015 May 5 , 754 (52-60).

Le Scouarnec S et al. Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome.
Hum. Mol. Genet., 2015 May 15 , 24 (2757-63).

Zhu JF et al. Novel heterozygous mutation c.4282G>T in the SCN5A gene in a family with Brugada syndrome.
Exp Ther Med, 2015 May , 9 (1639-1645).

Chahine M Gating pore current is a novel biophysical defect of Nav1.5 mutations associated with unusual cardiac arrhythmias and dilation.
Future Cardiol, 2015 May , 11 (287-91).

Marionneau C et al. Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J. Mol. Cell. Cardiol., 2015 May , 82 (36-47).

Liu GX et al. Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.
Heart Rhythm, 2015 May , 12 (1036-45).

Tan BY et al. A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore.
Europace, 2015 Mar 31 , ().

Mishra S et al. Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts.
J. Physiol. (Lond.), 2015 Mar 15 , 593 (1409-27).

Murray JK et al. Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel.
J. Med. Chem., 2015 Mar 12 , 58 (2299-314).

Ossola D et al. Force-controlled patch clamp of beating cardiac cells.
Nano Lett., 2015 Mar 11 , 15 (1743-50).

Liang W et al. Wnt signalling suppresses voltage-dependent Na(+) channel expression in postnatal rat cardiomyocytes.
J. Physiol. (Lond.), 2015 Mar 1 , 593 (1147-57).

De Filippo P et al. Cavotricuspid isthmus ablation and subcutaneous monitoring device implantation in a 2-year-old baby with 2 SCN5A mutations, sinus node dysfunction, atrial flutter recurrences, and drug induced long-QT syndrome: a tricky case of pediatric overlap syndrome?
J. Cardiovasc. Electrophysiol., 2015 Mar , 26 (346-9).

Hayashi K et al. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.
Circ Arrhythm Electrophysiol, 2015 Jun 30 , ().

Behr ER et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.
Cardiovasc. Res., 2015 Jun 1 , 106 (520-9).

Mercier A et al. Nav1.5 channels can reach the plasma membrane through distinct N-glycosylation states.
Biochim. Biophys. Acta, 2015 Jun , 1850 (1215-23).

Wannous R et al. Suppression of PPARβ, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities.
Pflugers Arch., 2015 Jun , 467 (1249-59).

Stroemlund LW et al. Gap junctions - guards of excitability.
Biochem. Soc. Trans., 2015 Jun , 43 (508-12).

Nikulina SY et al. An investigation of the association of the H558R polymorphism of the SCN5A gene with idiopathic cardiac conduction disorders.
Genet Test Mol Biomarkers, 2015 Jun , 19 (288-94).

Huang Y et al. Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II.
Peptides, 2015 Jun , 68 (175-82).

Daimi H et al. Absence of family history and phenotype-genotype correlation in pediatric Brugada syndrome: more burden to bear in clinical and genetic diagnosis.
Pediatr Cardiol, 2015 Jun , 36 (1090-6).

Winkel BG et al. The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.
Heart Rhythm, 2015 Jun , 12 (1241-9).

Daimi H et al. Regulation of SCN5A by microRNAs: miR-219 modulates SCN5A transcript expression and the effects of flecainide intoxication in mice.
Heart Rhythm, 2015 Jun , 12 (1333-42).

Cai T et al. Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels.
Peptides, 2015 Jun , 68 (148-56).

Stattin EL et al. Genetic screening in sudden cardiac death in the young can save future lives.
Int. J. Legal Med., 2015 Jul 31 , ().

Watanabe H et al. Genetics of Brugada syndrome.
J. Hum. Genet., 2015 Jul 30 , ().

Torregrosa R et al. Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Bioorg. Med. Chem., 2015 Jul 1 , 23 (3655-66).

Chow CY et al. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Toxins (Basel), 2015 Jul , 7 (2494-513).

Hasdemir C et al. High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.
Heart Rhythm, 2015 Jul , 12 (1584-94).

Verstraelen TE et al. The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders.
Neurogastroenterol. Motil., 2015 Jul , 27 (906-13).

Zhang J et al. Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine.
Eur. J. Pharmacol., 2015 Jan 5 , 746 (333-43).

Chong E et al. Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation.
Heart Rhythm, 2015 Jan 30 , ().

Saber S et al. Complex genetic background in a large family with Brugada syndrome.
Physiol Rep, 2015 Jan 1 , 3 ().

Baruteau AE et al. Inherited progressive cardiac conduction disorders.
Curr. Opin. Cardiol., 2015 Jan , 30 (33-9).

Kirchhof P et al. First report on an inotropic peptide activating tetrodotoxin-sensitive, "neuronal" sodium currents in the heart.
Circ Heart Fail, 2015 Jan , 8 (79-88).

Park DS et al. Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J. Clin. Invest., 2015 Jan , 125 (403-12).

Wilde AA et al. Bringing home the bacon? The next step in cardiac sodium channelopathies.
J. Clin. Invest., 2015 Jan , 125 (99-101).

Hothi SS et al. p.Y1449C SCN5A mutation associated with overlap disorder comprising conduction disease, Brugada syndrome, and atrial flutter.
J. Cardiovasc. Electrophysiol., 2015 Jan , 26 (93-7).

Riuró H et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome.
Eur. J. Hum. Genet., 2015 Jan , 23 (79-85).

Huang CW et al. The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents.
Neuroscience, 2015 Feb 26 , 287 (125-36).

Schwoerer AP et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels.
Anesth. Analg., 2015 Feb 16 , ().

de Llano CT et al. Further evidence of the association between LQT syndrome and epilepsy in a family with KCNQ1 pathogenic variant.
Seizure, 2015 Feb , 25 (65-7).

Moreau A et al. Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.
J. Gen. Physiol., 2015 Feb , 145 (93-106).

Beltran-Alvarez P et al. Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel.
Amino Acids, 2015 Feb , 47 (429-34).

Zhang H et al. Reporting sodium channel activity using calcium flux: pharmacological promiscuity of cardiac Nav1.5.
Mol. Pharmacol., 2015 Feb , 87 (207-17).

Zhu W et al. Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry.
Prog. Biophys. Mol. Biol., 2015 Dec 25 , ().

Peters CH et al. Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes.
Prog. Biophys. Mol. Biol., 2015 Dec 20 , ().

Veerman CC et al. The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.
Gene, 2015 Dec 1 , 573 (177-87).

Qureshi SF et al. Mutational analysis of SCN5A gene in long QT syndrome.
Meta Gene, 2015 Dec , 6 (26-35).

Glynn P et al. Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.
Circulation, 2015 Aug 18 , 132 (567-77).

Varga Z et al. Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.
Circ Arrhythm Electrophysiol, 2015 Aug 17 , ().

Lo YC et al. Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells.
Br. J. Pharmacol., 2015 Aug 15 , ().

Potet F et al. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
Circ Arrhythm Electrophysiol, 2015 Aug , 8 (933-41).

Pucca MB et al. Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: Evidence of a pro-inflammatory toxin on macrophages.
Biochimie, 2015 Aug , 115 (8-16).

Kapplinger JD et al. Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
Circ Cardiovasc Genet, 2015 Aug , 8 (582-95).

Peigneur S et al. A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms.
Neuropharmacology, 2015 Apr 7 , ().

Willis BC et al. Protein Assemblies of Sodium and Inward Rectifier Potassium Channels Control Cardiac Excitability and Arrhythmogenesis.
Am. J. Physiol. Heart Circ. Physiol., 2015 Apr 10 , (ajpheart.00176.2015).

Algalarrondo V et al. Abnormal sodium current properties contribute to cardiac electrical and contractile dysfunction in a mouse model of myotonic dystrophy type 1.
Neuromuscul. Disord., 2015 Apr , 25 (308-20).

Williams VS et al. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome.
Europace, 2015 Apr , 17 (635-41).

Iqbal SM et al. Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase.
Cell. Physiol. Biochem., 2015 , 37 (825-37).

Chang YS et al. Mutation Analysis of KCNQ1, KCNH2 and SCN5A Genes in Taiwanese Long QT Syndrome Patients.
Int Heart J, 2015 , 56 (450-3).

Yamanushi TT et al. Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy.
Folia Morphol. (Warsz), 2015 , 74 (258-61).

100

Leong IU et al. Assessment of the predictive accuracy of five in silico prediction tools, alone or in combination, and two metaservers to classify long QT syndrome gene mutations.
BMC Med. Genet., 2015 , 16 (34).

101

Nelson M et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.
Mol. Cancer, 2015 , 14 (13).

102

Obejero-Paz CA et al. Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.
Sci Rep, 2015 , 5 (17623).

103

Hu RM et al. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis.
PLoS ONE, 2015 , 10 (e0124921).

104

Han Z et al. Deletion of PDK1 causes cardiac sodium current reduction in mice.
PLoS ONE, 2015 , 10 (e0122436).

105

Saito Y et al. Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.
PLoS ONE, 2015 , 10 (e0138193).

106

Wang L et al. De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome.
Cell. Physiol. Biochem., 2015 , 36 (2250-62).

107

Allegue C et al. Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
PLoS ONE, 2015 , 10 (e0133037).

108

Selga E et al. Comprehensive Genetic Characterization of a Spanish Brugada Syndrome Cohort.
PLoS ONE, 2015 , 10 (e0132888).

109

Marcsa B et al. A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease.
PLoS ONE, 2015 , 10 (e0132137).

110

Poulet C et al. Late Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial Fibrillation.
PLoS ONE, 2015 , 10 (e0131432).

111

House CD et al. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Sci Rep, 2015 , 5 (11541).

112

Wang Y et al. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
PLoS ONE, 2015 , 10 (e0128653).

113

Mirams GR et al. Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
J Pharmacol Toxicol Methods, 2014 Nov-Dec , 70 (246-54).

114

Brugada R et al. Brugada syndrome.
Methodist Debakey Cardiovasc J, 2014 Jan-Mar , 10 (25-8).

115

Sällström J et al. Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: Heart rate-dependent effects during sinus rhythm in conscious telemetered dogs.
J Pharmacol Toxicol Methods, 2014 Jan-Feb , 69 (24-9).

116

Sayeed MZ et al. Brugada syndrome with a novel missense mutation in SCN5A gene: a case report from Bangladesh.
Indian Heart J, 2014 Jan-Feb , 66 (104-7).

117

Sun S et al. The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.
Bioorg. Med. Chem. Lett., 2014 Sep 15 , 24 (4397-401).

118

Ho GD et al. Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg. Med. Chem. Lett., 2014 Sep 1 , 24 (4110-3).

119

Frenz CT et al. NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.
J. Neurophysiol., 2014 Sep 1 , 112 (1091-104).

120

Bartok A et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K(+) channels.
Toxicon, 2014 Sep , 87 (6-16).

121

van Hoeijen DA et al. Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.
Expert Opin Pharmacother, 2014 Sep , 15 (1875-87).

122

Cai B et al. Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit.
J. Mol. Cell. Cardiol., 2014 Sep , 74 (297-306).

123

Pappalardo LW et al. Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis.
Neuroreport, 2014 Oct 22 , 25 (1208-15).

124

Shi D et al. Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
J. Cell. Mol. Med., 2014 Oct , 18 (1992-9).

125

Poulin H et al. Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.
Mol. Pharmacol., 2014 Oct , 86 (378-89).

126

Boehringer T et al. SCN5A mutations and polymorphisms in patients with ventricular fibrillation during acute myocardial infarction.
Mol Med Rep, 2014 Oct , 10 (2039-44).

127

Wang X et al. Angiotensin-(1-7) prevent atrial tachycardia induced sodium channel remodeling.
Pacing Clin Electrophysiol, 2014 Oct , 37 (1349-56).

128

Liu M et al. Cardiac sodium channel mutations: why so many phenotypes?
Nat Rev Cardiol, 2014 Oct , 11 (607-15).

129

Shy D et al. Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!
Circ. Res., 2014 Nov 7 , 115 (901-3).

130

Makara MA et al. Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
Circ. Res., 2014 Nov 7 , 115 (929-38).

131

Zhao Z et al. Cilostazol ameliorates atrial ionic remodeling in long-term rapid atrial pacing dogs.
Anatol J Cardiol, 2014 Nov 11 , ().

132

Gillet L et al. Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques.
Cardiovasc. Res., 2014 Nov 1 , 104 (231-3).

133

Chatin B et al. Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.
Biochem. J., 2014 Nov 1 , 463 (339-49).

134

Agullo-Pascual E et al. Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.
Cardiovasc. Res., 2014 Nov 1 , 104 (371-81).

135

Beltran-Alvarez P et al. Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart.
J. Mol. Cell. Cardiol., 2014 Nov , 76 (126-9).

136

Baskar S et al. Compound heterozygous mutations in the SCN5A-encoded Nav1.5 cardiac sodium channel resulting in atrial standstill and His-Purkinje system disease.
J. Pediatr., 2014 Nov , 165 (1050-2).

137

Xu L et al. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus.
Toxicon, 2014 Nov , 90 (318-25).

138

Ilkhanoff L et al. A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.
J. Cardiovasc. Electrophysiol., 2014 Nov , 25 (1150-7).

139

Frolov RV et al. Celecoxib and ion channels: a story of unexpected discoveries.
Eur. J. Pharmacol., 2014 May 5 , 730 (61-71).

140

Baptista-Hon DT et al. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function.
Br J Anaesth, 2014 May 22 , ().

141

Klint JK et al. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.
Biochem. Pharmacol., 2014 May 15 , 89 (276-86).

142

Wang GK et al. Block of human cardiac sodium channels by lacosamide: evidence for slow drug binding along the activation pathway.
Mol. Pharmacol., 2014 May , 85 (692-702).

143

Zhao J et al. Relationship between two arrhythmias: sinus node dysfunction and atrial fibrillation.
Arch. Med. Res., 2014 May , 45 (351-5).

144

Wang Q et al. Gain-of-function KCNH2 mutations in patients with Brugada syndrome.
J. Cardiovasc. Electrophysiol., 2014 May , 25 (522-30).

145

Hartman ME et al. Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.
FASEB J., 2014 Mar 31 , ().

146

Zidar N et al. Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators.
Eur J Med Chem, 2014 Mar 3 , 74 (23-30).

147

Andreasen L et al. Brugada syndrome risk loci seem protective against atrial fibrillation.
Eur. J. Hum. Genet., 2014 Mar 26 , ().

148

Cerrone M et al. Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.
Circulation, 2014 Mar 11 , 129 (1092-103).

149

Gandjbakhch E et al. Malignant response to ajmaline challenge in SCN5A mutation carriers: experience from a large familial study.
Int. J. Cardiol., 2014 Mar 1 , 172 (256-8).

150

Chang RK et al. Genetic variants for long QT syndrome among infants and children from a statewide newborn hearing screening program cohort.
J. Pediatr., 2014 Mar , 164 (590-5.e1-3).

151

Liu C et al. Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder?
Forensic Sci. Int., 2014 Mar , 236 (38-45).

152

Elíes J et al. Inhibition of the cardiac Na⁺ channel Nav1.5 by carbon monoxide.
J. Biol. Chem., 2014 Jun 6 , 289 (16421-9).

153

Yang T et al. Screening for Acute IKr Block is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current.
Circulation, 2014 Jun 3 , ().

154

Gao G et al. Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.
J. Am. Coll. Cardiol., 2014 Jun 3 , 63 (2261-9).

155

Boczek NJ et al. Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring Kv4.3 Protein Inhibitor and its Contribution to Brugada Syndrome.
Circ. Res., 2014 Jun 24 , ().

156

Coleman N et al. New Positive KCa Channel Gating Modulators with Selectivity for KCa3.1.
Mol. Pharmacol., 2014 Jun 23 , ().

157

Ben-Johny M et al. Conservation of Ca(2+)/Calmodulin Regulation across Na and Ca(2+) Channels.
Cell, 2014 Jun 19 , 157 (1657-70).

158

Zhang Y et al. Measurement and interpretation of electrocardiographic QT intervals in murine hearts.
Am. J. Physiol. Heart Circ. Physiol., 2014 Jun 1 , 306 (H1553-7).

159

Aiba T et al. A mutation causing brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.
Circ Cardiovasc Genet, 2014 Jun , 7 (249-56).

160

Yin G et al. Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.
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