Referenced in: none

Automatically associated channels: Kv1.1 , Kv1.5

Title: Deletion of highly conserved C-terminal sequences in the Kv1 K+ channel sub-family does not prevent expression of currents with wild-type characteristics.

Authors: V N Uebele, S W Yeola, D J Snyders, M M Tamkun

Journal, date & volume: FEBS Lett., 1994 Feb 28 , 340, 104-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8119390

Abstract
The C-terminal regions of Kv1 K+ channels show little conservation between isoforms except for the last four C-terminal residues, (E/L)TDV, which are well conserved from Drosophila to man. Deletions of the 4, 16, and 57 C-terminal residues of the human Kv1.5 channel did not affect whole cell current amplitude, midpoint of activation, degree of inactivation, or activation kinetics following expression in mouse L-cells. Similar results were obtained with the rat Kv1.1 channel. Therefore, the conserved (E/L)TDV motif, and most of the C-terminal amino acids, are not required for Kv1 channel expression.