Referenced in: none

Automatically associated channels: Kv10.1

Title: [Ion channels in non excitable cells]

Authors: G C Bertrán, C D'Alessio, B A Kotsias

Journal, date & volume: Medicina (B Aires), 1995 , 55, 449-56

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8728776

Abstract
Several distinct types of voltage-gated and second-messenger-operated K+, Ca2+, Na+ and Cl- channels exist in electrically non excitable cells such as those of the hematopoietic lineage. In these cells ion channels mediate cellular functions involving intracellular biochemical responses, rather than rapid electrical signaling. The presence of the channels is required for several basic functions, such as activation, secretion of lymphokines, mitogenesis, the regulation of cell volume and the mechanisms of resistance to chemotherapeutic agents. Here IN we review the patch-clamp method for studying many characteristics of these ionic channels, particularly in blood cells.