Referenced in: none

Automatically associated channels: ClC1 , ClC4

Title: A voltage-gated chloride channel in the yeast Saccharomyces cerevisiae.

Authors: M E Huang, J C Chuat, F Galibert

Journal, date & volume: J. Mol. Biol., 1994 Sep 30 , 242, 595-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7932715

Abstract
We report the sequencing and identification on chromosome X of Saccharomyces cerevisiae of an open reading frame whose product, designated yClC-1, displays significant structural similarity to a voltage-gated Cl- channel family. This putative protein contains 13 hydrophobic domains very similar to transmembrane domains exhibited by known members of this family. Some amino acids in the domains and at the loops between them are well conserved among all members. This is the first voltage-gated Cl- channel described in the yeast S. cerevisiae. The identification of yClC-1 will facilitate the functional analysis of Cl- channels in general, and should also assist in the identification of other ClC genes in higher eukaryotes.