Referenced in: none

Automatically associated channels: Kv10.1

Title: Arabidopsis NPH1: a protein kinase with a putative redox-sensing domain.

Authors: E Huala, P W Oeller, E Liscum, I S Han, E Larsen, W R Briggs

Journal, date & volume: Science, 1997 Dec 19 , 278, 2120-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9405347

Abstract
The NPH1 (nonphototropic hypocotyl 1) gene encodes an essential component acting very early in the signal-transduction chain for phototropism. Arabidopsis NPH1 contains a serine-threonine kinase domain and LOV1 and LOV2 repeats that share similarity (36 to 56 percent) with Halobacterium salinarium Bat, Azotobacter vinelandii NIFL, Neurospora crassa White Collar-1, Escherichia coli Aer, and the Eag family of potassium-channel proteins from Drosophila and mammals. Sequence similarity with a known (NIFL) and a suspected (Aer) flavoprotein suggests that NPH1 LOV1 and LOV2 may be flavin-binding domains that regulate kinase activity in response to blue light-induced redox changes.