Channelpedia

PubMed 9254841


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: cacnb2 , cacnb4



Title: Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.

Authors: S Taviaux, M E Williams, M M Harpold, J Nargeot, P Lory

Journal, date & volume: Hum. Genet., 1997 Aug , 100, 151-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9254841


Abstract
We have used human beta 2 and beta 4 cDNA probes to map the genes encoding two isoforms of the regulatory beta subunit of voltage-activated Ca2+ channels, viz. CACNB2 (beta 2) and CACNB4 (beta 4), to human chromosomes 10p12 and 2q22-q23, respectively, by fluorescence in situ hybridization. The gene encoding the beta 2 protein, first described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS. CACNB2 (beta 2) and CACNB4 (beta 4) genes are members of the ion-channel gene superfamily and it should now be possible to examine their loci by linkage analysis of ion-channel-related disorders. To date, no such disease-related gene has been assigned to 10p12 and 2q22-q23.