Referenced in: none

Automatically associated channels: BKβ1

Title: The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade.

Authors: A Kelley-Hedgepeth, I Peter, Ke Kip, Mc Montefusco, S Kogan, D Cox, Jm Ordovas, D Levy, Se Reis, Me Mendelsohn, D Housman, Gs Huggins

Journal, date & volume: , 2008 Jul , 22, 512-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18418400

Abstract
Genetic polymorphisms that influence smooth muscle cell contraction and relaxation may affect the response to anti-hypertensive therapy. Our finding of lower blood pressure (BP) in the setting of treatment for hypertension, particularly with beta-blockade, in Caucasian KCNMB1-E65K-carriers in two community cohorts has implications for personalization of therapy in hypertension.