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PubMed 9450690


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Automatically associated channels: Nav1.8



Title: Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia.

Authors: A L Oaklander, A J Belzberg

Journal, date & volume: Brain Res. Mol. Brain Res., 1997 Dec 1 , 52, 162-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9450690


Abstract
Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.