Referenced in: none

Automatically associated channels: Kir6.2 , Kv3.4 , Slo1

Title: Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern.

Authors: D Vullhorst, R Klocke, J W Bartsch, H Jockusch

Journal, date & volume: FEBS Lett., 1998 Jan 16 , 421, 259-62

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9468318

Abstract
We report the detailed expression pattern of the voltage-dependent potassium channel KV3.4 (rat homologue, Raw3) in mouse skeletal muscle. Using semi-quantitative RT-PCR, we show that its expression is detectable at embryonic day 17 and rises to adult levels within 2 weeks after birth. Expression is fiber type-dependent, with mRNA levels being 5-6-fold lower in the mixed slow/fast soleus muscle than in the fast tibialis anterior and extensor digitorum longus muscles. Fast muscles from myotonic mice exhibit low KV3.4 mRNA levels similar to those of wild-type soleus. In denervated extensor digitorum longus, KV3.4 expression declines to perinatal levels. We conclude that KV3.4 expression in mouse skeletal muscle is regulated by the pattern of excitation.