Channelpedia

PubMed 9217874


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: HCN3 , Kir6.1 , Kir6.2



Title: Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs.

Authors: M Horie, A Ishida-Takahashi, T Ai, T Nishimoto, Y Tsuura, H Ishida, Y Seino, S Sasayama

Journal, date & volume: Cardiovasc. Res., 1997 Apr , 34, 69-72

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9217874


Abstract
Cardiovascular drugs such as antiarrhythmic agents with Vaughan Williams class Ia action have been found to induce a sporadic hypoglycemia. Recent investigation has revealed that these drugs induce insulin secretion from pancreatic beta-cells by inhibiting ATP-sensitive K+ (KATP) channels in a manner similar to sulfonylurea drugs. The mechanism underlying block of KATP channels by antiarrhythmic drugs was different, however, from that of sulfonylureas: firstly, because binding of radioactive glibenclamide could not be inhibited by unlabelled antiarrhythmic agents, and vice versa; secondly, because the two compounds differ in the kinetics and sidedness of drug action-antiarrhythmic drugs act on the channel from the inner surface of the cell membrane, whereas glibenclamide binds through the intramembrane pathway; finally, it was shown that functional KATP channels in beta-cells are composed of two distinct molecules-a sulfonylurea receptor (SUR) and a channel pore-forming subunit, an inwardly-rectifying K channel with two transmembrane regions (Kir6.2). Antiarrhythmic drugs reversibly inhibit the K+ conductance displayed by the Kir6.1 (a putative KATP channel clone)-transfected NIH3T3 cells. Therefore they appear to interact directly with the pore-forming subunit, thereby inhibiting KATP channel currents and exerting an insulinotrophic effect.